Extra's

Question 1

What is the role of PPAR’s?

Answer 1

transcription factors that regulate gene expression (metabolic processes)

• increases the concentration of enzymes required for oxidizing fatty acids.

Question 2

What is the role of Citrate Synthase?

Answer 2

• Catalyses formation of citrate from acetyl coA and oxaloacetate initiating the Krebs Cycle.

Increased citrate synthase = increased, mitochondrial density, increased oxidative capacity, improved endurance.

• Measured after exercise.

Increases during states of low glycogen content.

Question 3

What is the role of pyruvate dehydrogenase ?

Answer 3

Bridge between glycolysis and Krebs cycle.

Concerts pyruvate into Acetyl coA for the Krebs cycle

enzyme that controls entry of substrates into krebs cycle.

Question 4

What comes first? Citrate synthase or pyruvate dehydrogenase?

Answer 4

Pyruvate dehydrogenase.

As converts pyruvate into acetyl coA

Citrate synthase initiates krebs cycle by combining acetyl coA with oxaloacetate forming citrate.