Extra from ADE flashcards Flashcards by Umma Raja | Brainscape

Q

What is a hepatoma?

A

Malignant liver tumour

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Q

What is a seminoma?

A

Malignant testicular tumour

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Q

What is a lymphoma?

A

Malignant tumour of lymphocytes

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Q

CML - what is the main cell type affected?

A

Haematopoetic stem cell

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Q

Gene expressed in breast cancers is?

A

HER2

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Q

Gene expressed in lung and colorectal cancers is?

A

EGFr

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Q

Transtuzumab targets which gene?

A

HER2

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Q

Bevacizumab targets which gene?

A

VEGF

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Q

Two genes causing lung cancer

A

EGFR

ALK

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Q

Cause of resistance to tyrosine kinase inhibitors

A

ABL1 kinase

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Q

Loss of p53 results in?

A

Evasion of apoptosis

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Q

Activation of H-ras oncagene results in?

A

Self-sufficiency of growth signals

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Q

Inactivation of E-cadherin causes?

A

Tissue invasion and metastasis

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Q

Activation of telomerase causes?

A

Limitless reproductive potential

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Q

Sarcoma is derived from where?

A

Mesenchymal tumour

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