Exotoxins

Question 1

2 bugs with exotoxins that inactivate EF-2?

Answer 1

C. diptheriae (diptheria toxin)

P. aeruginosa (exotoxin A)

Question 2

2 bugs with exotoxins that remove adenine from rRNA–> inhibition of 60S?

Answer 2

Shigella (shiga toxin)

EHEC (shiga-like toxin)

Question 3

2 bugs with exotoxins that permanently activate Gs–> over-activate adenylate cyclase–> increasing cAMP and leading to watery diarrhea

Answer 3

ETEC (LT)

V. cholerae (cholera factor)

Question 4

Which bug’s exotoxin overactivates adenylate cyclase by disabling Gi?

Answer 4

B. pertussis (pertussis toxin)

Question 5

Which 2 bugs have exotoxins that mimic adenylate cyclase?

Answer 5

B. anthracis (edema factor)

B. pertussis (adenylate cyclase toxin)

Question 6

Which 2 bugs have exotoxins that degrade cell membranes?

Answer 6

C. perfringens (alpha toxin- a phospholipase)

S. pyogenes (streptolysin O)

Question 7

Which 2 bugs have exotoxins that function as superantigens and cause shock?

Answer 7

S. aureus (TSST-1)

S. pyogenes (exotoxin A)

Question 8

Which bug has 2 exotoxins: one that binds the gut brush border and one that causes actin depolymerization, leading to cytoskeletal disruption?

Answer 8

C. diff:
Toxin A= enterotoxin
Toxin B= cytotoxin