Antifungals: MOAs Flashcards by No Name | Brainscape

Q

Amphotericin B

A

Binds ergosterol–> membrane pores–> leakage of electrolytes

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Q

Nystatin

A

Binds ergosterol–> membrane pores–> leakage of electrolytes

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Q

Azoles (class)

A

Inhibit fungal ergosterol synthesis by inhibiting lanosterol 14-alpha demethylase, the fungal p450 enz that normally converts lanosterol–> ergosterol

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Q

Fluconazole

A

Azole
(Inhibit fungal ergosterol synthesis by inhibiting lanosterol 14-alpha demethylase, the fungal p450 enz that normally converts lanosterol–> ergosterol)

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Q

Ketoconazole

A

Azole
(Inhibit fungal ergosterol synthesis by inhibiting lanosterol 14-alpha demethylase, the fungal p450 enz that normally converts lanosterol–> ergosterol)

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Q

Clotrimazole

A

Azole
(Inhibit fungal ergosterol synthesis by inhibiting lanosterol 14-alpha demethylase, the fungal p450 enz that normally converts lanosterol–> ergosterol)

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Q

Miconazole

A

Azole
(Inhibit fungal ergosterol synthesis by inhibiting lanosterol 14-alpha demethylase, the fungal p450 enz that normally converts lanosterol–> ergosterol)

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Q

Itraconazole

A

Azole
(Inhibit fungal ergosterol synthesis by inhibiting lanosterol 14-alpha demethylase, the fungal p450 enz that normally converts lanosterol–> ergosterol)

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Q

Voriconazole

A

Azole
(Inhibit fungal ergosterol synthesis by inhibiting lanosterol 14-alpha demethylase, the fungal p450 enz that normally converts lanosterol–> ergosterol)

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Q

Flucytosine

A

Converted to 5-FU by cytosine deaminase–> inhibits RNA and DNA biosynth

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Q

Echinocandins (class)

A

Inhibit synthesis of beta-glucan–> inhibits fungal cell wall synth

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Q

Caspofungin

A

Echinocandin

Inhibit synthesis of beta-glucan–> inhibits fungal cell wall synth

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Q

Micafungin

A

Echinocandin

Inhibit synthesis of beta-glucan–> inhibits fungal cell wall synth

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Q

Anidulafungin

A

Echinocandin

Inhibit synthesis of beta-glucan–> inhibits fungal cell wall synth

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Q

Terbinafine

A

Inhibits squalene epoxidase–> build-up of intracellular squalene–> toxic

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Q

Griseofulvin

A

Interferes with microtubule function–> disrupts mitosis. Forms deposits in keratin-containing tissues