Exam Two Flashcards
Describe the two locus model (# of genes, gamete frequencies, possible combos)
Two genes, haplotype frequencies are gamete frequencies, ab/aB/Ab/AB
Give the general description of linkage equilibrium
The frequency of an allele is the same in both pairs (B pairs with A at the same rate (%) as it does with a)
What are the three definitions of linkage equilibrium?
The frequency of B in gametes carrying allele A is equal to the frequency of B in gametes carrying allele a
The frequency of any gamete haplotype can be calculated by multiplying the frequencies of the constituent alleles.
The quantity D, known as the coefficient of linkage disequilibrium, is equal to zero.
Give the general definition of linkage disequilibrium
The frequency of an allele is different in both pairs (B pairs with A at the different rate as it does with a)
Is linkage equilibrium/disequilibrium connected to allele frequencies?
No, there may be two groups of gametes with the same allele frequencies, but one is in linkage equilibrium and one is in linkage disequilibrium
What three things cause linkage disequilibrium in a population that was once in equilibrium?
Multilocus selection, drift, admixture
What is the general term for the mechanism that can restore linkage equilibrium in a population that is in disequilibrium, and what are the two subtypes?
Recombination
Independent assortment when genes are on different chromosomes and crossover between chromosomes when genes are on the same chromosome
Explain this equation: D= gABgab - gAbgaB
D is the coefficient of linkage disequilibrium, it is equal to zero during linkage equilibrium
Explain this equation: gAB’ = gAB -rD
It shows how much the gamete frequencies change from generation to generation. r is the recombination frequency and D is the coefficient of linkage disequilibrium.
Describe the maximum and minimum values of r, and what will increase or decrease it
r ranges from .5 when the genes are on different chromosomes to close to zero when the genes are very close together
Explain this equation: D’ = D(1-r)
This explains how much D changes from generation to generation. It will always be reduced (r is always above 0), but it is reduced faster with a higher value of r
Why was linkage disequilibrium distressing to evolutionary biologists, and why did they not have to worry?
It introduced another variable. They did not have to worry because it goes away quickly.
Describe Muller’s rachet
We all have some deleterious alleles, but in sexual reproduction, they are less likely to meet up.
In asexuals, the average number of deleterious mutations increases over generations
In a sexual population some progeny have fewer deleterious alleles the average, or more.The lower fitness are purged .
What are the three advantages of sexual reproduction?
Creation of new genotypes, eliminate genotypes with deleterious alleles, and recreates genotypes that were lost
What are quantitative traits?
Traits that are controlled by multiple genes
Describe the difference between genotypic variation and environmental varation
Genotypic is different genes, environmental is difference due to environment
Explain this equation: R=h^2S
R is response to selection (how much population will change), h superscript 2 is heritability in the narrow sense, and S is selection differential
What two things make up total phenotypic variation?
genetic variation and environment
What is the equation for heritability in the broad sense?
variation from different genes over total phenotypic varation
What three things make up genetic variability?
Interaction between genes, dominance effects, and additive effects (number of contributing alleles)
What is the equation for heritability in the narrow sense?
H superscript two is equal to variation from additive effects over total phenotypic variation
How is heritability in the narrow sense estimated?
Midparent value graphed against midoffspring value with the slope of the best fit line being equal to heritability
How do you calculate selection differential in nature?
Graph trait of parents against relative fitness, selection gradient is the slope, convert into S by multiplying by variance for trait
What is the equation for relative fitness?
Absolute fitness of a given phenotype over mean for population
What is the equation for absolute fitness?
number of offspring by a given phenotype over number produced by the most fit
Name the three types of selection for quantitative traits
Directional, Stabilizing, Disruptive