Exam questions Flashcards
What are the functions of the tongue?
Articulation, Mastication, Deglutition, Taste and Oral Cleaning
What is an infection?
a disease caused by microorganisms that invade tissue
What is pain threshold?
The lowest intensity of a stimulus which a subject can recognise as pain
What is resistant to antibiotics and what is it called?
Microbes, this is called primary drug resistance
What structures does the oral cavity consist of?
Outer part (vestibule), inner part (oral cavity), teeth, mucosa
What is Analgesia?
Absence of pain in response to stimulation which would normally be painful
What are antibiotics?
A chemical substance produced by microorganisms that can destroy or inhibit the growth of bacteria and other microbes in dilute solution
What is Odontogenic?
An infection involving teeth or associated tissue caused by oral pathogens
What is a gland?
A structure that produces chemical secretion necessary for body functioning
What are the functions of the Lymphatic system?
Maintain fluid balance in internal environment, hematopoieses, helps distribute fluids and nutrients in body, defence systems
What are the 4 resistance mechanisms of antibiotics?
Drug inactivation, altered drug targets, barrier to entry, active elimination of the antibiotic
What is Hyperalgesia?
an increased response to a stimulus which is normally painful
What are the superficial lymph nodes of the head?
Occipital, Retro-auricuclar, Pre-auricuclar, superficial parotid, facial
What do oral pathogens inhabit?
Surface of teeth, oral mucosa membrane, gingival crevice, saliva
Why are antibiotics used in oral health?
To treat periodontitis, skull fractures, endocarditis
What are the type of ductal system glands?
Exocrine glands, endocrine glands
What is an example of drug inactivation?
drug-inactivating enzymes
What is the Trige-minal Nerve?
Largest and most important cranial nerve and is the principal general sensory nerve for the head
What is the process of microbial oral colonisation?
Transmission, Acquisition, Pioneer species, Succession, Diversity, Climax Community
What is Paraesthesia?
An abnormal sensation, whether spontaneous or evoked
What are the 5 ways antibiotics work?
Inhibition of cell wall synthesis, inhibition of protein synthesis, inhibition of nucleic acid synthesis, Disruption of cell membrane function, Interfere with metabolite use
What can Odontogenic infections cause?
compromised airways, Ludwig’s angina, Cavernous sinus thrombosis
What is one of the types of drug inactivating enzymes and what does it do?
Beta-lactamase - destroys B-lactams
What are nature of secretion glands?
Serous glands, Mucous glands, Mixed glands
What are the Deep lymph nodes on the head?
Deep parotid & retropharyngeal
What is the process of pain?
Transduction - Transmission - Perception
What is hematopoiesis?
Formation of new blood cells
What is Articulation?
Tongue making contact with other structures and regulates air flow
What can cause odontogenic infections?
Immunodeficiency, Hepatitis
What are examples of inhibition of cell wall synthesis?
Penicillin
What does a serous gland produce?
a thin secretion
What are the superficial Cervical lymph nodes?
Submental, Submandibular, External Jugular, Anterior Jugular
What is the process through the body for pain to be detected?
receptor - Peripheral nerve (Afferent) - spinal cord - brain stem - cerebral cortex
What are examples of altered drug targets?
Mutated penicillin-binding proteins, modified lipopolysaccharide (LPS)
How does the Lymphatic system maintain fluid balance?
Plasma filters into interstitial spaces from blood flowing through capillaries
What are consequences of odontogenic infections?
Soft tissue abscess, Bacteraemia, Deep fascial space infection, cerebral infection, cellulitis
What is an example of disruption of cell membrane function?
polymixin
What does a mucous gland produce?
A vicious slimy secretion mucus
What is fast pain transmitted by?
large thick myelinated A-delta fibres
Where does the tri-geminal nerve emerge from?
From the pons and has a large sensory root & a small motor root
What is an example of inhibition of protein synthesis?
streptomycin
What is an example of barrier to entry?
loss of porins - resistance to carbapenems
What are the three odontogenic infection lesions?
Abscess, Osteomyelitis, Cellulitis
Where is the submental lymph node located?
Within the sub mental triangle, superficial to mylohyoid bone
What is microbial colonisation dependent on?
Tolerance to conditions, Nutritional requirements
What is slow pain transmitted by?
small non-myelinated C fibres carrying dull persistent pain at slow pulses
What does a mixed gland produce?
both a serous and a mucous secretion
What is an example of active elimination of the antibiotic?
efflux pumps - membrane bound proteins that actively pump out antibacterials or anti fungals out of the cell
What are features of Absces?
localised entrapment of pathogens, filled with pus that passes through the past of least resistance to emerge in a surface
What is an example of inhibition of nucleic acid synthesis?
quinolones (DNA replication)
What is oedema?
Fluid that remains and causes swelling
Where is the submandibular lymph node located?
At the inferior border of the mandibular ramus, superficial to submandibular salivary gland
What is Mastication?
Process of chewing and swallowing
Where do First-order Neurons start - finish?
from sensory receptors and end in dorsal horn of spinal cord
What are point mutations?
single base changes which may result in changed or inactive proteins
What is the structure of a salivary gland?
A series of secretory units clustered around a central lumen
What are treatments for abscess?
removal of cause, surgical drainage, antibiotics
What is an example of action as antimetabolites?
sulfonilaminde
What are frameshift mutations?
insertions/ deletions which result in inactive proteins
What is the sensory root features?
Has three nerve divisions called ophthalmic, maxillary, mandibular
Where do Second-order neurons start & finish?
Dorsal horns as they recieve pulses from FON, travel along the lateral spinothalmic tract, and end at the thalamus
What are the areas drained by submental LNs?
Mandibular incisors & associated tissue, chin, lip
What are the defense systems of the lymphatic system?
Mechanical filtration of particles, biological filtration ( phagocytosis) and activates immune system
What is horizontal gene transfer?
The process by which an organism incorporates genetic material from another organism without being the offspring of the donor organism
What are the 3 major Salivary glands?
Parotid, Submandibular, Sublingual
What are the types of Abscess?
Periapical Abscess, Gingival Abscess, Pericoronal Abscess, Periodontal Abscess
What are the anti-fungal drugs?
5-fluorocytosine, Azoles and Triazoles, Polyenes, Echinocandins
What genetic material is transferred in horizontal gene transfer?
Plasmids, DNA from lysed cells
Where do the third-order neurons start & finish?
At the thalamus, ends in cerebral cortex
What acquisition of oral bacteria is there at 3 months?
Streptococcus (70%), Staphylococcus, Actinomyces
What is Cellulitis?
inflammation of soft tissue spaces
What are areas drained by submandibular LNs?
Teeth (expect mandibular incisors), posterior floor of mouth, body of the tongue
What are features of the parotid salivary gland?
Largest, produces watery secretion containing enzymes, two lobes
What is the function of 5-fluorocytosine?
Inhibits DNA and RNA synthesis
What are plasmids?
extrachromosomal genetic elements
What is Deglutition?
Mixes food with saliva and forms the bolus
What is lymphadenitis?
Micro-organisms infecting the node
What is Somatic pain?
superficial pain, deep somatic pain
What are symptoms of Cellulitis?
indurated palpation, firm swelling, tenderness
What are features of the motor root?
It accompanies the mandibular nerve through the foramen ovale
What are plasmids function?
To replicate independently of the chromosome
What is the function of Azoles and Triazoles?
Inhibit sterol biosynthesis
What is gate control theory?
the perception of pain is modulated by a “gate” mechanism in the spinal cord, which can open or close to regulate the transmission of pain signals to the brain.
What is the anatomical location of the parotid salivary gland?
Superficial lobe, anterior to external ear between skin and massester muscle, deep lobe inferior to external ear
What is the outcome of Cellulitis?
Ludwigs Angina, skin necrosis
What are the areas drained by the superior deep cervical LNs?
posterior hard palate & soft palate, base of tongue, maxillary 3rd molars, TMJ
What are plasmids good for?
antibiotic resistance, toxins or antimicrobial proteins, cell surface structures
Why is dental plaque important?
Causes dental caries, causes gingivitis and periodontal diseases
What is Hematopoiesis?
formation of blood cellular components that are derived from haematopoietic cells
What is the location of stenson’s duct?
Superficial to the massester, parotid papilla marks the opening of the duct
What is the treatment for Cellulitis?
Antibiotics, removal of cause
What is the action of Polyenes?
Causes plasma membrane to leak H+ and K+ ions
What is visceral pain origin?
Originates from internal organs
Where is the tongue located?
In the oral cavity and the oropharynx
What are the areas drained by inferior deep cervical LNs?
Posterior portion of scalp, neck, superior deep cervical LNs
What is the action of Echinocandins?
Inhibit glucan synthesis
What does the parotid salivary gland enclose?
External Carotid artery, retromandibular vein, Facial nerve, Auriculotemporal nerve
What are the Ophthalmic sensory nerves?
sensory fibres to the scalp, ethmodial and frontal paranasal sinuses, lacrimal glands, and a portion of the dura mater
What is Osteromyelitis?
Inflammation of bone marrow, common in mandible and maxilla
What is Neuropathic pain?
a result of a disorder in the nerves
What is vertical gene transfer?
Microbes duplicating their entire chain of DNA before dividing to form two cells, each daughter cells contains identical info.
What is dental plaque?
The complex microbial community found on the tooth surface embedded in a matrix of polymers of bacterial and salivary origin, is biofilm
What disease can be found in Accessory & supraclavicular LNs?
Cancer from lungs, oesophagus, stomach
What are the therapy options for oral candidosis?
Amphotericin B lozenges, Miconazole oral gel, Fluconazole capsules
What is Psychogenic pain?
individual feels pain but the cause is emotional rather than physical
What are symptoms of Osteomyelitis?
paraestheia in the lower lip, discharging sinuses
What are mumps features?
A viral infection, redness of parotid papilla, becomes enlarged and tender
What are the three mechanisms of horizontal gene transfer between bacterial strains or species?
Transduction (virus mediated), Transformation (uptake of free DNA), Conjugation (cell-to-cell DNA transfer)
What are components within the lymphatic system?
Lymph vessels, Lymph tissues ( lymph nodes, isolated nodules, Lymphoid structures, spleen)
What covers the tongue?
pink specialised mucosa
What are potential therapy issues for Oral Candidosis?
Fluconazole resistance, Recurrence of infection
What is the treatment for osteomyelitis?
removal of cause, antibiotics
What is Lymphadenopathy?
A bacterial infection that swells the lymph nodes causing cancer or tumours
What is the genetic recombination of the three mechanisms of HGT?
Re-arrangement of DNA by breaking and rejoining homologous sequences
What happens if a patient has Parotitis?
Postpone dental treatment for 5 days from symptoms
How does the ophthalmic nerve enter the orbit?
Leaves trig-menial ganglion and enters orbit through superior orbital fissure
What are the functions of the spleen?
removes microorganisms by phagocytosis, red blood cells and platelet destruction by phagocytosis, blood reservoir
What is Lymphadentitis?
Inflammation along the lymphatic vessels