Exam qs 12/13

Question 1

Select a neurotransmitter whose synaptic action is terminated primarily by enzymatic breakdown

Answer 1

acetylcholine

Question 2

Which of the following has the greatest efficacy:
A. competitive antagonist
B. full agonist
C. non-competitive antagonist
D. partial agonist

Answer 2

full agonist

Question 3

The potency of a drug is a measure of:

Answer 3

the dilution in which the drug can evoke a specified effect

Question 4

A high pA2 value implies that an antagonist is

Answer 4

potent

Question 5

A drug may be said to exhibit selectivity when

Answer 5

its EC50 at one receptor type is greater than at a second receptor type

Question 6

Sympathetic ganglia differ from parasympathetic ganglia in:

Answer 6

their anatomical locations

Question 7

Cis and Trans conformation are form of what kind of isomerism?

Answer 7

geometric

Question 8

After binding an agonist, a number of events must occur before cytoplasmic nuclear hormone receptors can alter the transcription of DNA. These events occur in the following order:

Answer 8

Heat shock proteins dissociate; receptor dimerizes; receptor translocates to the nucleus

Question 9

A drug that inhibits transport of cholesterol across the brush border of enterocytes is

Answer 9

ezetimibe

Question 10

a class of drugs used to treat bronchial asthma are…

Answer 10

β2-adrenoceptor agonists

Question 11

A type of angina in which attacks can be relieved by rest is…

Answer 11

stable angina

Question 12

a phosphodiesterase inhibitor that is used as a second-line treatment for heart failure:

Answer 12

milrinone

Question 13

Thiazide diuretics are often prescribed for the treatment of…

Answer 13

hypertension

Question 14

The phenylalkylamine antidysrhythmic drugs act selectively at the following class of calcium channel:

Answer 14

L-type

Question 15

Lidocaine, at low concentrations, does not block normal cardiac action potentials because it:

Answer 15

dissociates rapidly from voltage-gated sodium channels