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Immunology > EXAM III T/F > Flashcards

EXAM III T/F Flashcards

1
Q

Activation of TLRs can lead to expression of B7 on an APC

A

True

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2
Q

B7 on a an APC can bind CD28 on a T cell

A

True

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3
Q

B7 is a “costimulatory signal”

A

True

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4
Q

Antigenic stimulation, without costimulation, leads to T cell inactivation

A

True

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5
Q

Central tolerance is established in the lymph nodes

A

False

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6
Q

Peripheral tolerance is established in the lymph nodes

A

True

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7
Q

Peripheral tolerance is established in the bone marrow and thymus

A

False

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8
Q

Oral administration of an antigen can lead to tolerance

A

True

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9
Q

Treg cells may induce tolerance

A

True

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10
Q

Myasthenia gravis is caused by antibodies to acetylcholine receptors

A

True

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11
Q

Myasthenia gravis causes involuntary contraction of the muscles

A

False

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12
Q

Transfer of antibodies from a person with myasthenia gravis to a normal person could results in a transient case of myasthenia gravis

A

True

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13
Q

Immunization of an animals with acetylcholine receptors and adjuvant could give rise to a condition resembling myasthenia gravis

A

True

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14
Q

“TI” or thymus independent antigens typically give rise to IgE antibodies

A

False

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15
Q

Changes in adhesion molecules or chemokine receptors can lead to changes in cell location

A

True

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16
Q

“Homing” refers to the return of B cells and T cells to the bone marrow

A

False

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17
Q

Migration of B cells is accomplished by “taking the bus” by sticking to chemotactic phagocytes

A

False

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18
Q

New B cells are produced more or less throughout life

A

True

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19
Q

New T cells are produced primarily early in life

A

True

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20
Q

Mature B cells express IgD and IgM on their surface

A

True

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21
Q

Memory B cells express IgD and IgM on their surface

A

False

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22
Q

Mature B cells express IgG, IgA, or IgE on their surface

A

False

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23
Q

Memory B cells express IgG, IgA, or IgE on their surface

A

True

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24
Q

CD32, a low affinity FC receptor on B cells, is activated by antigen and antibody complexes, and negatively regulates further antibody production

A

True

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25
Q

A large percentage of TH cells can be activated by superantigens

A

True

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26
Q

Concanavalin A activates T cells

A

True

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27
Q

Phytohemagglutinin activates T cells

A

True

28
Q

Pokeweed mitogen activates T cells

A

True

29
Q

Pokeweed mitogen activates B cells

A

True

30
Q

LPS activates T cells

A

False

31
Q

LPS activates B cells

A

True

32
Q

IL-8 is a chemokine

A

True

33
Q

IFN-gamma is a chemokine

A

False

34
Q

CRP is made by a macrophage

A

False

35
Q

CRP can “fix complement”

A

True

36
Q

CRP can induce fever

A

false

37
Q

CRP is made by the liver

A

True

38
Q

CRP binds to phosphocholine

A

True

39
Q

TNF-alpha is made by the liver

A

False

40
Q

TNF-alpha is made by macrophages

A

True

41
Q

TNF-alpha binds to phosphocholine

A

False

42
Q

TNF-alpha can “fix complement”

A

False

43
Q

TNF-alpha can induce fever

A

True

44
Q

TNF-alpha is proinflammatory cytokine

A

True

45
Q

TNF-alpha is a pyrogen

A

True

46
Q

TNF-alpha is a chemokine

A

False

47
Q

IFN-gamma is important for fighting mycobacteria

A

True

48
Q

IFN-gamma is important for activating macrophages

A

True

49
Q

IFN-gamma is produced by TH1 cells

A

True

50
Q

IGN-gamma inhibits TH2 and TH17 cells

A

True

51
Q

GM-CSF can promote growth of granulocytes

A

True

52
Q

GM-CSF can promote growth of macrophages

A

True

53
Q

IL-2 can promote growth of T cells

A

True

54
Q

TNF-alpha is a target for rheumatoid arthritis drugs

A

True

55
Q

TGF-beta immunosuppressive cytokine

A

True

56
Q

Expression of FasL may be important in immune privileged sites

A

True

57
Q

Presence of TLR ligands makes immune responses weaker

A

False

58
Q

Intravenous administration of antigen is maximally immunogenic

A

False

59
Q

Oral Administration of antigen can be tolerizing

A

True

60
Q

Poorly immunogenic substances, such as lipids, nucleic acids and small compounds can be made more immunogenic by conjugating them to a carrier protein

A

True

61
Q

Plasma cells secrete antibody

A

True

62
Q

Memory cells secrete antibody

A

False

63
Q

Plasma cells have membrane bound antibody

A

False

64
Q

Memory cells have membrane bound antibody

A

True

65
Q

Antigenic stimulation of immature B cells leads to deletion or anergy

A

True

66
Q

Antigenic stimulation of immature B cells leads to proliferation

A

False

67
Q

Central tolerance is established in the bones marrow and thymus

A

True

Immunology (11 decks)

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