EXAM III T/F

Question 1

Activation of TLRs can lead to expression of B7 on an APC

Answer 1

True

Question 2

B7 on a an APC can bind CD28 on a T cell

Answer 2

True

Question 3

B7 is a “costimulatory signal”

Answer 3

True

Question 4

Antigenic stimulation, without costimulation, leads to T cell inactivation

Answer 4

True

Question 5

Central tolerance is established in the lymph nodes

Answer 5

False

Question 6

Peripheral tolerance is established in the lymph nodes

Answer 6

True

Question 7

Peripheral tolerance is established in the bone marrow and thymus

Answer 7

False

Question 8

Oral administration of an antigen can lead to tolerance

Answer 8

True

Question 9

Treg cells may induce tolerance

Answer 9

True

Question 10

Myasthenia gravis is caused by antibodies to acetylcholine receptors

Answer 10

True

Question 11

Myasthenia gravis causes involuntary contraction of the muscles

Answer 11

False

Question 12

Transfer of antibodies from a person with myasthenia gravis to a normal person could results in a transient case of myasthenia gravis

Answer 12

True

Question 13

Immunization of an animals with acetylcholine receptors and adjuvant could give rise to a condition resembling myasthenia gravis

Answer 13

True

Question 14

“TI” or thymus independent antigens typically give rise to IgE antibodies

Answer 14

False

Question 15

Changes in adhesion molecules or chemokine receptors can lead to changes in cell location

Answer 15

True

Question 16

“Homing” refers to the return of B cells and T cells to the bone marrow

Answer 16

False

Question 17

Migration of B cells is accomplished by “taking the bus” by sticking to chemotactic phagocytes

Answer 17

False

Question 18

New B cells are produced more or less throughout life

Answer 18

True

Question 19

New T cells are produced primarily early in life

Answer 19

True

Question 20

Mature B cells express IgD and IgM on their surface

Answer 20

True

Question 21

Memory B cells express IgD and IgM on their surface

Answer 21

False

Question 22

Mature B cells express IgG, IgA, or IgE on their surface

Answer 22

False

Question 23

Memory B cells express IgG, IgA, or IgE on their surface

Answer 23

True

Question 24

CD32, a low affinity FC receptor on B cells, is activated by antigen and antibody complexes, and negatively regulates further antibody production

Answer 24

True

Question 25

A large percentage of TH cells can be activated by superantigens

Answer 25

True

Question 26

Concanavalin A activates T cells

Answer 26

True

Question 27

Phytohemagglutinin activates T cells

Answer 27

True

Question 28

Pokeweed mitogen activates T cells

Answer 28

True

Question 29

Pokeweed mitogen activates B cells

Answer 29

True

Question 30

LPS activates T cells

Answer 30

False

Question 31

LPS activates B cells

Answer 31

True

Question 32

IL-8 is a chemokine

Answer 32

True

Question 33

IFN-gamma is a chemokine

Answer 33

False

Question 34

CRP is made by a macrophage

Answer 34

False

Question 35

CRP can "fix complement"

Answer 35

True

Question 36

CRP can induce fever

Answer 36

false

Question 37

CRP is made by the liver

Answer 37

True

Question 38

CRP binds to phosphocholine

Answer 38

True

Question 39

TNF-alpha is made by the liver

Answer 39

False

Question 40

TNF-alpha is made by macrophages

Answer 40

True

Question 41

TNF-alpha binds to phosphocholine

Answer 41

False

Question 42

TNF-alpha can "fix complement"

Answer 42

False

Question 43

TNF-alpha can induce fever

Answer 43

True

Question 44

TNF-alpha is proinflammatory cytokine

Answer 44

True

Question 45

TNF-alpha is a pyrogen

Answer 45

True

Question 46

TNF-alpha is a chemokine

Answer 46

False

Question 47

IFN-gamma is important for fighting mycobacteria

Answer 47

True

Question 48

IFN-gamma is important for activating macrophages

Answer 48

True

Question 49

IFN-gamma is produced by TH1 cells

Answer 49

True

Question 50

IGN-gamma inhibits TH2 and TH17 cells

Answer 50

True

Question 51

GM-CSF can promote growth of granulocytes

Answer 51

True

Question 52

GM-CSF can promote growth of macrophages

Answer 52

True

Question 53

IL-2 can promote growth of T cells

Answer 53

True

Question 54

TNF-alpha is a target for rheumatoid arthritis drugs

Answer 54

True

Question 55

TGF-beta immunosuppressive cytokine

Answer 55

True

Question 56

Expression of FasL may be important in immune privileged sites

Answer 56

True

Question 57

Presence of TLR ligands makes immune responses weaker

Answer 57

False

Question 58

Intravenous administration of antigen is maximally immunogenic

Answer 58

False

Question 59

Oral Administration of antigen can be tolerizing

Answer 59

True

Question 60

Poorly immunogenic substances, such as lipids, nucleic acids and small compounds can be made more immunogenic by conjugating them to a carrier protein

Answer 60

True

Question 61

Plasma cells secrete antibody

Answer 61

True

Question 62

Memory cells secrete antibody

Answer 62

False

Question 63

Plasma cells have membrane bound antibody

Answer 63

False

Question 64

Memory cells have membrane bound antibody

Answer 64

True

Question 65

Antigenic stimulation of immature B cells leads to deletion or anergy

Answer 65

True

Question 66

Antigenic stimulation of immature B cells leads to proliferation

Answer 66

False

Question 67

Central tolerance is established in the bones marrow and thymus

Answer 67

True