Exam II Flashcards
What 3 characteristics do members of the Plasmodiidae have in common, relative to their sporozoite, type of life cycle, and location of each phase of the cycle?
- sporozoites are the infective stage that’s found in the mosquito
Of the 4 species of Plasmodium that infect humans, which shows the greatest prevalence?
Of the 4 species of Plasmodium that infect humans, which shows the lowest prevalence?
What is the prevalence of malaria?
what is the incidence of malaria?
what is the annual mortality of malaria?
what is the malaria vector?
How does the malaria vector introduce the parasite into the body?
Once sporozoites enter the bloodstream (in malaria), which cells do they infect first?
Once sporozoites enter the bloodstream (in malaria), by what indirect process do they arrive at their final destination cell?
What stage of the vertebrate life cycle is this called in malaria?
In what form do merozoites enter the bloodstream in malaria?
Of the 4 human-infecting species, which produces the most merozoites in the shortest period of time?
Define hypnozoite.
In which species of malaria does hypnozoite occur?
What is the clinical significance of a hypnozoite?
What is the definition of relapse?
What are the events during invasion of a red blood cell by a merozoite (in malaria)?
what is meant by a moving junction (in malaria)?
What stage of the vertebrate life cycle does the moving junction begin?
Can merozoites re-infect liver cells?
Are all stages of red blood cells equally susceptible to invasion by all species?
Which species prefers which RBC stage?
How does the preference of RBC cells explain the observed levels of parasitemia that develop in the different species?
What are the stages of development that the parasite undergoes in the red blood cell in malaria?
what are the morphological features associated with each stage in malaria?
What are some of the key morphological features that allow you to distinguish one species from another, e.g., morphology of the trophozoite, presence or absence of Schuffner’s dots, appearance of infected red blood cell?
What is hemozoin?
Why does P. falciparum seemingly “disappear” from the peripheral blood at a particular stage, and what advantage does the parasite gain?
Why is the disappearance of P. falciparum from the peripheral blood a problem for the patient?
- Which species produces the most merozoites from red blood cells in the shortest time (in malaria)?
What is the explanation for the periodic chills and fever associated with malaria?
What is the timing of the periods for each of the 4 human-infecting species of malaria?
What is recrudescence?
which species demonstrates recrudescence?
How does recrudescence differ from relapse?
What two paths of development can the merozoite undergo (in malaria)?
What stage indicates the beginning of gametogony?
Where are gametes finally formed (in malaria)?
Why is microgametogenesis referred to as “exflagellation?”
Where does sporogony occur?
what developmental stages are involved in sporogony?
what is the final product of sporogony?
What is the complete life cycle of Plasmodium, including all stages of development in both the mosquito and human host?
In which host does gametogony begin, and in which host is it concluded?
What are the main symptoms of malaria?
In which groups are the symptoms worst in malaria?
What causes the high fever in malaria?
Why do malaria patients show marked anemia?
What is the complication caused by P. malariae and what is the mechanism?
What are the complications specifically associated with malaria caused by P. falciparum?
Which is the most dangerous complication of malaria caused by P. falciparum?
What is a possible consequence of the severe immunosuppression caused by P. falciparum?
What genetic traits are found in people living in certain P. falciparum transmission areas?
What genetic traits are found in people living in certain in certain P. vivax transmission areas?
- What is the evidence for immune protection during initial infection?
What is the evidence that protective immunity against reinfection actually occurs against malaria?
What type of immunity is the protective immunity (e.g., compared to sterile immunity induced by the polio vaccine)?