Exam 5 part 3 Flashcards
What drug used for thyroid replacement interacts with warfarin by increasing its effect? What should be monitored closely?
levothyroxine
PT/INR and bleeding
What drug interactions occur with levothyroxine?
warfarin and digoxin
Because vitamins and supplements can decrease the absorption of levothyroxine, when should they be taken?
4 hrs after taking levothyroxine
Levothyroxine decreases the effect of digoxin, so which symptoms should be monitored very closely?
s/s heart failure (edema, SOB< crackles, activity intolerance, etc)
What s/s may indicate overmedication of levothyroxine?
hyperthyroidism (tachycardia, weightloss, hyperactivity)
What adverse effects may occur in a patient with a thyroid replacement patient receiving levothyroxine?
aFIB, bone loss, overmedication/hyperthyroidism
What are the indications of methimazole and propylthiouracil?
hyperthyroidism, goiter, thyroid storm, and Grave’s disease
If crushing a levothyroxine tablet, what should it be mixed with?
water
If a patient is receiving propylthiouracil for hyperthyroidism, what tests are important to monitor frequently?
liver function tests (Black box warning for hepatic toxicity)
What is a major adverse effect concern with antithyroid medications (methimazole)?
hypothyroidism
what pregnancy category is methimazole (drug for hyperthyroidism)?
Category D
what food group should those taking methimazole avoid?
sea food due to iodine content
Agranulocytosis may occur as a result of receiving methimazole, so this assessment is indicated?
CBC to monitor for agranulocytosis( low wbc) that may lead to infection
What symptoms may occur as a result of stopping methimazole abruptly?
thyroid storm/crisis (tachycardia, fever, flushing, restlessness, behavior changes)
what medications may be used in diabetes insipidus?
vasopressin and desmopressin