Exam 5 - Fibrinolytics

Question 1

What is the purpose of the Fibrinolysis Pathway?

Answer 1

Fibrinolysis is the degradation process of fibrin via plasmin, a fibrin‐specific protease

Question 2

tPA – tissue plasminogen activator MOA:

Answer 2

binds to fibrin in order to convert plasminogen to plasmin; the activated plasmin degrades the fibrin

Question 3

tPA indication:

Answer 3

treatment of ischemic stroke

*must be administered within 3 hours of stroke

Question 4

Plasminogen:

Answer 4

Activated to plasmin by tPA

Question 5

PAI‐1 and 2:

Answer 5

inhibits fibrinolyic activity of tPA

Question 6

α2‐AP; α2‐antiplasmin:

Answer 6

Binds to free plasmin and inactivates it

Question 7

Alteplase (Activase) MOA:

Answer 7

Higher affinity for fibrin‐bound plasminogen vs free – converts plasminogen to plasmin

Question 8

Reteplase (Retavase) MOA:

Answer 8

Decreased selectivity and affinity for fibrin vs alteplase – converts plasminogen to plasmin

Question 9

Tenecteplase (TNKase) t1/2, elimination:

Answer 9

t1/2 = 17 minutes; hepatic elimination