Drug Structure and Functional Groups

Question 1

Biological Target:

Answer 1

Enzyme, receptor, transporter, nucleic acid, or other biological enzyme

Key part of biological process

Question 2

Ligand:

Answer 2

Substance that forms a complex with a biomolecule to serve a biological purpose

Question 3

Pharmacophore:

Answer 3

The ensemble of steric and electronic features that is necessary to ensure the optimal submolecular, interactions with a specific biological target structure to trigger or block its biological response

Question 4

Structure-Activity-Relationships (SAR):

Answer 4

The relationship between structural features of a molecule contribute to or take away from the desired biological activity

Question 5

pKa:

Answer 5

Relates to acidity of a molecule

Question 6

pH:

Answer 6

Relates to acidity of environment

Question 7

Log difference in pKa and pH (Absolute):

Answer 7

0 = 1:1; 1 = 1:10; 2 = 1:100; 3 = 1:1000