Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm > exam 5 estrogen progestin gi and such > Flashcards

exam 5 estrogen progestin gi and such Flashcards

1
Q

Estrogen that is absorbed slowly, prolonged duration when esterified and IM injection

RT for primary hypOgonadism
post men RT

most potent
inc first pass

A

Estradiol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Estrogen-
Insoluble in H2O
monthly OC

A

estradiol cyionate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Estrogen-
has dec first pass
OC

A

ethinyl estradiol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Estrogen receptor ANTagonist

tx of hormone responsive MT breast cancer

A

Fulvestrant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Non-steroidal estrogen modulator
used for estrogen dependent breast cancer
anti-estrogen on breast
pro-estrogen on lipids bones and uterus

A

tamoxifen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

non-steroidal ER modulator

  • used for prevention of osteoporosis/dec risk of breas cancer in postmen
  • lowers cholesterol, not in hdl
A

raloxifene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Third gen progestin

  • OC
  • Ovarian suppression
  • Lowest androgenic activity
A

Desogestrol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Endometrial protection in ERT, 2ndry amenorrhea, suppress dysmenorrhea, endometriosis, vaginal bleeding disorders

A

medroxyprogesterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q 
2nd class progestin
OC
ovarian suppression
varying androgenic activity
A

norethindrone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Norethindrone derivative, 1st trimester abortion, inc uterine contraction with misoprostol

antag, dec prostaglandin dehyrogenase
inc contraction of uterine sm

ae vaginal bleeding and abd pain

A

Mifepristone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

weak bases that react with HCl to form salt and water to inc pH to 4.2-4.7.

  • protect Gi mucosa thru stimulation of prostaglandin production
  • neutralize gastric activity; prolonged if taken with food
A

Antacids
Aluminum Hydroxide
Magnesium Hydroxide

Mg faster than Al

side effect of Al=constipation
Mg= diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Suppress 24hr gastric secretion

A

cimetidine

H2R antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

administered as inactive prodrug, protonated, blocks H+/K+ atpase. stops parietal cells

-give 1hr before meal on empty stomach
rapid first pass

A

PPI
Omeprazole
=DOC for gastrinoma and hyper H+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

prevent traveler’s diarrhea, direct anti microbial activity against h.pylori

can cause tongue and stool blackening
CI: renal insufficiency

A

Bismuth subsalicylate

mucosal protective agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

PG E1 analog

  • Inc mucosal blood flow
  • Buffer H+
  • stimulates mucus and bicarb secretion

Use PO for prevention of EtOh and NSAID assoc ulcers

A

Misoprostol

mucosal protective agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

sucrose salt

-prevent bleeding from stress related gastritis

A

sucralfate

mucosal protective agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

agonists on enteric neurons 5ht-4 receptors in atch release

-anti nausea and anti-emetic effect

A

metoclopramide

=prokinetic

18
Q
  • fecal softener
  • stool surfactant agent
  • allow water and lipids to penetrate stool to soften it
A

Laxative

-Docusate

19
Q

osmotic

inc fecal fluidity and stool liquidity

A

Laxative

magnesium oxide

20
Q

for IBS

  • serotonin 5-HT3 R antag
  • PO for severe IBS in women w/ diarrhea as predominate symptom
A

alonestron

21
Q

produces IBD remission in 50-60% pts and maintained up to 80%
SE: bone marrow suppression, liver toxicity, hypersens rxn’s
requires LFT and blood chem tests

A

Azathioprine

22
Q

for IBD
-anti TNF therapy for mod to severe crohns and uc in acute/chronic pts
AE: infection due to suppression of th1

A

infliximab

23
Q

for IBD
-induce and maintain remission in crohns
-inc dose=inc SE
enhanced by FOLATE supplements

A

methotrexate

24
Q

for IBD
first line of drug for mild to mod UC
produces and maintains remission

A

sulfasalazine

25
Q

antiemietic
-selective serotonin 5-ht3 antagonist
-useful in comiting from vagal stim and chemo
DOC cuz no blocking of DA receptors

A

Ondansetron

26
Q

antiemetic

  • block NK1 receptor
  • used in combo with cortico and 5HT3-R antag as prophylaxis
A

Aprepitant

27
Q

antiemetic

-prevent postsurgical nausea vomiting

A

droperidol

28
Q

antiemetic
-DA D2 receptor antagonist
migraine assoc vomitting

A

promethasize

29
Q

binds Fe, fails to compete with biological chelated iron

A

deferoxamine

30
Q

bdendate chelator react with metals reactivates cellular sulfhydryl-containing enzymes-arsenic, mercrury, and lead chelator

A

dimercaprol

31
Q

chelator of divalent/trivalent cations in vitro

  • coadminister calcium to prevent depeltion
  • metals capable of binding edta and displacing ca are chellators
A

EDTA-edetate calcium disodium

32
Q

produces lead diiuresis similar to edta, PO with few SE for tx of children with blood lead concentrations >45 ug/L

A

Succimer

33
Q

immune stimulant, may inc macrophage activity and enhance NKC

A

echinacea

34
Q

contains ephedrine (sympathomimetic)

  • 16x risk of hemorrhagic stroke in women taking phenylpropanolamine as appetite suppressant
  • dietary supplement to promote wt loss and inc energy
A

ephedra

35
Q

tx for nausea a/w motion/morning sickness.

use with anticoags is problematic since prolongs bleeding time

A

ginger

36
Q

promoted as being physically, mentally, and sexually invigorating

  • anti stress properties
  • may also inhibit platelet aggregation
A

ginseng

37
Q

herbal remedy for dementia nd circulator disorders

  • can inc acetylcholine activity and affect serotonin and norepinephrine
  • relax vascular smooth muscle and prevent platelet activation
  • anti-oxidant activity
A

Ginko balboa

38
Q

anxiolytic, sedative, and sleep aid

-enhance Gaba-ergic activity. similar to benzodiazepines

A

Kava

39
Q

Tx of benign prostatic hyperplasia.
improve UT symptoms similar to finasteride.
-inhibit testosterone 5-a reductase, anti-androgenic and anti-estrogenic effects

A

saw palmetto

40
Q

enhance production of cyp3a enzymes which metabolize a host of toxins and drugs

A

st. johns wort

Pharm (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions