Exam 3 Flashcards
Transmitter depleters of NE
dec symp tone, affect adrenergic nerve terminal to dec NT release of NE
Reserpine
Guanethidine
RG3
Alpha-2 agonists
inc NTS, dec symp, reverse LVH, dec cholesterol
clonidine
Alpha-methyl dopa
Cl-Alpha
Alpha-1 antagonists
block sympathetic tone in vasculature, dec cholesterol
Doxazosin
Prazosin
“-AZOSINS”
B-blockers
dec cardiac output, dec force of cardiac contraction, dec renin
“-olols”
non selective: propran, labet
B1 cardio- selective: acebut, aten, metop
Saluretics
-initial dec in Na and fluid and BP
inexpensive first line of drug choice
Hydrochlorothiazide
chlorthalidone
-Potassium sparing-
spironolactone
amiloride
“Spiro Ate potassium”
Smooth muscle vasodilators
-dec peripheral resistance
Hydralazine
Minoxidil
Nitroprusside
“How many ninjas”
hydras, minotaurs, nitro
ACE inhibitors
angiotensin converting enzyme
competitively antagonize conversion of Angio1 to Angio2
inhibit breakdown of bradykinin (vasodilator)
“Pril”
captopril
enalapril
fosinopril
“Cats eat fish”
ARBs
competitive antagonists of type 1 angio2 receptor
more effective than ACE since some angio2 can be produced outside the RA pathway
-“Sartans”
losartan
valsartan
LOVA
Renin inhibitor
binds renin and inhibit cleavage of angiotensinogen->angiotensin 1
CI PREGNANCY
Aliskiren
Calcium channel blocker
produce VSM relaxation and dec peripheral resistance
Nifedipine
verapamil
diltiazem
Niggas very dark
PDE5 inhibitor
vsm relaxation
Sildenafil
Antiarrhythmic
Class 1A
med recovery
Quinidine
Procainamide
queen proclaims
Antiarrhythmic
Class 1B
rapid recovery
Lidocaine
Mexiletine
little mexican
Antiarrhythmic
Class 1C
slow recovery, atrial arrhythmia with no deformity/CAST
flecainide
propafenone
flex professionally
Antiarrhythmic
Class 3
phase 3, block K+ efflux
- prolong reploarization
- affect nodal/muscle repolarization
Amiodarone
Sotalol
Ibutilide
Dofetilide
Amy sought ibiza dope
Cardiotonics-digitalis
-REVERSIBLE INHIBITION OF NA/K ATPase
Digoxin
Digitoxin
Diglet digs
Beta 1 agonists
+ inotrope
Dopamine
Dobutamine
dobby dopes
Antianginals
nitrates
b blockers
calcium channel blockers
Beta 2 agonists
rapid bronchodilation
Long acting beta 2 agonists
taken with corticosteroids when chronic
“-terols”
albuterol
terbutaline
formoterol
salmetrol
asthma trouble from santa
Inhaled glucocorticoid/corticosteroid
systemic
Inhaled:
budesonide
fluticasone
systemic:
Prednisone
budding flowers please
Muscarinic antagonists
inhibit PSNS
used in combo with b-2 steroids
-“Tropium”
ipratropium
tiotropium
IT
Leukotriene antagonists
antagonize immune effects
ie bronchoconstriction, mucus secretion, edema
-Lukast
Montelukast
Zafirlukast
Antibodies
reduces serum IgE, pt has to take less steroid
OmalizumAB
ab=antibody
Preventive agent
inhalant prophylactic asthma control
cromolyn
Fluticasone + salmeterol =??
Advair
Antiepileptics block sodium inhibit gaba inhibit ca channels inhibit glutamate receptors
Carbamazepine Gabapentin Lamotrigine Levitiracetam Oxcarbazeine Phenytoin Tiagabine Topiramate Volproic acid zonisamide
CGL LOP TTVZ
Anti epileptics
Benzodiazepines
gaba neuronal inhibition
-“Azepams”
clonazepam
diazepam
lorazepam
Typical Antipsychotics
Block dopamine receptors D2>D1
High potency
Fluphenazine
Haloperidol
Low potency
Chlorpromazine
Atypical Antipsychotics
diverse, useful in Tx resistant pts and noncompliant pts
Clozapine
Olanzapine
Risperidone
Aripiprazole
CORA
Anxiolytics
bind gaba receptors to increase inward cl conductance resulting in membrane hyperpolarization and neuronal inhibition
increase affinity of gaba(a) to gaba
sedation, anti anxiety, skeletal muscle relaxation, anti convulsant, antergrade amnesia
-“azepams”
chlordiazepoxide clonazepam clorazepate diazepam flurazepam lorazepam temazepam
Benzodiazepine agnoist
zolpidem
Benzodiazepine antag
flumazenil
Anxiolytic that aids in smoking cessation
buspirone
barbituates
reversibly depress activity of all excitable tissue
potentiate gaba
dec voltage gated ca
dec glutamate induced depolarizations
phenobarbital
thiopental
Tricyclic anti-depressants
inhibit NE or Serotonin (5-HT) uptake
-pramine or -tryptiline amitryptiline desipramine imipramine nortriptyline
amy desires indian norms
SSRI’s
inhibit uptake of serotonin
Citolopram
Fluoxetine
Paroxetine
sertraline
city flu plagues sundays
SNRIS
blocks NE, serotonin
duloxetine
velafaxine
Dem Vikings
MAOIs
dec metabolism of amines
phenelzine
selegiline
Play station
antimanic agents
lithium**
carbamazepine
lamotrigine
valproic acid
lithium: most specific drug for prophylaxis and tx for bipolar
has effect on neurohormonal signal transduction systems
