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Pharm > Exam 3 > Flashcards

Exam 3 Flashcards

1
Q

Transmitter depleters of NE

dec symp tone, affect adrenergic nerve terminal to dec NT release of NE

A

Reserpine
Guanethidine

RG3

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2
Q

Alpha-2 agonists

inc NTS, dec symp, reverse LVH, dec cholesterol

A

clonidine
Alpha-methyl dopa

Cl-Alpha

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3
Q

Alpha-1 antagonists

block sympathetic tone in vasculature, dec cholesterol

A

Doxazosin
Prazosin

“-AZOSINS”

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4
Q

B-blockers

dec cardiac output, dec force of cardiac contraction, dec renin

A

“-olols”
non selective: propran, labet
B1 cardio- selective: acebut, aten, metop

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5
Q

Saluretics

-initial dec in Na and fluid and BP

inexpensive first line of drug choice

A

Hydrochlorothiazide
chlorthalidone

-Potassium sparing-
spironolactone
amiloride

“Spiro Ate potassium”

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6
Q

Smooth muscle vasodilators

-dec peripheral resistance

A

Hydralazine
Minoxidil
Nitroprusside

“How many ninjas”

hydras, minotaurs, nitro

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7
Q

ACE inhibitors

angiotensin converting enzyme

competitively antagonize conversion of Angio1 to Angio2

inhibit breakdown of bradykinin (vasodilator)

A

“Pril”

captopril
enalapril
fosinopril

“Cats eat fish”

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8
Q

ARBs

competitive antagonists of type 1 angio2 receptor

more effective than ACE since some angio2 can be produced outside the RA pathway

A

-“Sartans”

losartan
valsartan

LOVA

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9
Q

Renin inhibitor

binds renin and inhibit cleavage of angiotensinogen->angiotensin 1

CI PREGNANCY

A

Aliskiren

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10
Q

Calcium channel blocker

produce VSM relaxation and dec peripheral resistance

A

Nifedipine
verapamil
diltiazem

Niggas very dark

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11
Q

PDE5 inhibitor

vsm relaxation

A

Sildenafil

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12
Q

Antiarrhythmic

Class 1A

med recovery

A

Quinidine
Procainamide

queen proclaims

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13
Q

Antiarrhythmic

Class 1B

rapid recovery

A

Lidocaine
Mexiletine

little mexican

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14
Q

Antiarrhythmic

Class 1C

slow recovery, atrial arrhythmia with no deformity/CAST

A

flecainide
propafenone

flex professionally

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15
Q

Antiarrhythmic

Class 3

phase 3, block K+ efflux

  • prolong reploarization
  • affect nodal/muscle repolarization
A

Amiodarone
Sotalol
Ibutilide
Dofetilide

Amy sought ibiza dope

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16
Q

Cardiotonics-digitalis

-REVERSIBLE INHIBITION OF NA/K ATPase

A

Digoxin
Digitoxin

Diglet digs

17
Q

Beta 1 agonists

+ inotrope

A

Dopamine
Dobutamine

dobby dopes

18
Q

Antianginals

A

nitrates
b blockers
calcium channel blockers

19
Q

Beta 2 agonists

rapid bronchodilation

Long acting beta 2 agonists

taken with corticosteroids when chronic

A

“-terols”
albuterol
terbutaline

formoterol
salmetrol

asthma trouble from santa

20
Q

Inhaled glucocorticoid/corticosteroid

systemic

A

Inhaled:
budesonide
fluticasone

systemic:
Prednisone

budding flowers please

21
Q

Muscarinic antagonists

inhibit PSNS

used in combo with b-2 steroids

A

-“Tropium”

ipratropium
tiotropium

IT

22
Q

Leukotriene antagonists

antagonize immune effects

ie bronchoconstriction, mucus secretion, edema

A

-Lukast

Montelukast
Zafirlukast

23
Q

Antibodies

reduces serum IgE, pt has to take less steroid

A

OmalizumAB

ab=antibody

24
Q

Preventive agent

inhalant prophylactic asthma control

A

cromolyn

25
Q

Fluticasone + salmeterol =??

A

Advair

26
Q 
Antiepileptics
block sodium
inhibit gaba
inhibit ca channels
inhibit glutamate receptors
A 
Carbamazepine
Gabapentin
Lamotrigine
Levitiracetam
Oxcarbazeine
Phenytoin
Tiagabine
Topiramate
Volproic acid
zonisamide

CGL LOP TTVZ

27
Q

Anti epileptics
Benzodiazepines

gaba neuronal inhibition

A

-“Azepams”

clonazepam
diazepam
lorazepam

28
Q

Typical Antipsychotics

Block dopamine receptors D2>D1

A

High potency
Fluphenazine
Haloperidol

Low potency
Chlorpromazine

29
Q

Atypical Antipsychotics

diverse, useful in Tx resistant pts and noncompliant pts

A

Clozapine
Olanzapine
Risperidone
Aripiprazole

CORA

30
Q

Anxiolytics

bind gaba receptors to increase inward cl conductance resulting in membrane hyperpolarization and neuronal inhibition

increase affinity of gaba(a) to gaba

sedation, anti anxiety, skeletal muscle relaxation, anti convulsant, antergrade amnesia

A

-“azepams”

chlordiazepoxide clonazepam
clorazepate
diazepam
flurazepam
lorazepam
temazepam
31
Q

Benzodiazepine agnoist

A

zolpidem

32
Q

Benzodiazepine antag

A

flumazenil

33
Q

Anxiolytic that aids in smoking cessation

A

buspirone

34
Q

barbituates

reversibly depress activity of all excitable tissue

potentiate gaba
dec voltage gated ca
dec glutamate induced depolarizations

A

phenobarbital

thiopental

35
Q

Tricyclic anti-depressants

inhibit NE or Serotonin (5-HT) uptake

A 
-pramine or -tryptiline
amitryptiline
desipramine
imipramine
nortriptyline

amy desires indian norms

36
Q

SSRI’s

inhibit uptake of serotonin

A

Citolopram
Fluoxetine
Paroxetine
sertraline

city flu plagues sundays

37
Q

SNRIS

blocks NE, serotonin

A

duloxetine
velafaxine

Dem Vikings

38
Q

MAOIs

dec metabolism of amines

A

phenelzine
selegiline

Play station

39
Q

antimanic agents

A

lithium**
carbamazepine
lamotrigine
valproic acid

lithium: most specific drug for prophylaxis and tx for bipolar
has effect on neurohormonal signal transduction systems

Pharm (19 decks)

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