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BECOM 3 > Exam #4 Pharmacology > Flashcards

Exam #4 Pharmacology Flashcards

1
Q

Breast cancer estrogen SERMs and Estrogen antagonist

A

SERMs: Tamoxifen, Toremifene

Estrogen Antagonist: Fulvestran, Clomiphene

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2
Q

Steroidal (irreversible) Aromatase Inhibitors

Indication

A

Exemestane
Formestane
Indication: 2nd line postmenopausal breast cancer

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3
Q

Non-steroidal (reversible) Aromatase Inhibitors

Indication

A

Anastrozole
Letrozole
Indication: 2nd line postmenopausal breast cancer

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4
Q

Estrogen/Progestin contraceptive adverse effects

A 
Thrombosis
MI
Hirsutism
Vaginal infection
Break through bleeding
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5
Q

Mifepristone MOA and indication

A

MOA: progesterone antagonist
Indication: early pregnancy termination

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6
Q

Ulipristal MOA and indication

A

MOA: progesterone antagonist
Indication: early pregnancy termination

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7
Q

Progestins MOA when used for contraception

A

dec GnRH pulse frequency

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8
Q

17-alpha Alkylated Androgens names, indication, and adverse effects

A

Methyltestosterone
Fluoxymesterone
Indication: Test def.
Adverse Effects: hepatitis, prostate cancer

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9
Q

Ester testosterone name and why good

A

Testosterona enanthate

longer half life and no hepatic effects

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10
Q

Danazol is used to treat and MOA

A

modified testosterone used to treat endometriosis

MOA: partial agonist of androgen receptor

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11
Q

Flutamide
MOA
Indication
Adverse Effects

A

MOA: testosterone receptor antagonist
Indication: hirsutism, prostate cancer
Adverse Effects: hepatotoxic

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12
Q

Rapid
Short
Intermediate
Long

A

Rapid: lispro
Short: regular insulin
Intermediate: NPH
Long: glargine, detemir

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13
Q

insulin side effects

A

hypoglycemia
hypokalemia
weight gain

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14
Q

metformin adverse effect

A

diarrhea
nausea
lactic acidosis (gluconeogensis is inhibited sending pyruvate to lactic acid)

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15
Q

Glybu(ride)
MOA
Indication
Adverse Effects

A

MOA: sulfaurea
Indication: type II diabetes
Adverse Effects: weight gain, hypoglycemia

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16
Q

Repa(glinide)
MOA
Indication
Adverse Effects

A

MOA: block K+ efflux channel
Indication: type II diabetes
Adverse Effects: weight gain, hypoglycemia
**non sulfa

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17
Q

Exena(tide)
MOA
Indication
Adverse Effects

A

MOA: GLP-1 analog (inc insulin, dec glucagon, inc satiety)
Indication: type II diabetes
Adverse Effects: pancreatic tumor, diarrhea

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18
Q

Sita(gliptin)
MOA
Indication
Adverse Effects

A

MOA: DPP-4 inhibitor inc GLP-1 (inc insulin, dec glucagon, inc satiety)
Indication: type II diabetse
Adverse Effects: pancreatitis

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19
Q

pancreatitis

A

Exena(tide)
Sita(gliptin)
Didanosine
Stavudine

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20
Q

Pio(glitazone)
MOA
Indication
Adverse Effects

A

MOA: activation of PPARy (inc TAG storage -> inc glucose utilization)
Indication: type II diabetes
Adverse Effects: heart failure, osteoporosis, weight gain

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21
Q

Acabose
MOA
Indication
Adverse Effects

A

MOA: a-amylase and a-glucosidase inhibitors decreasing glucose absorption
Indication: type II diabetes
Adverse Effects: flatulence, diarrhea

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22
Q

Canagli(flozin)
MOA
Indication
Adverse Effects

A

MOA: SGLT2 inhibitor
Indication: type II diabetes
Adverse Effects: UTI, mycotic infections, hypotension, renal impairment

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23
Q

Dinoprostone

A

PGE2

induces labor

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24
Q

Latanoprost

A

PGF2alpha

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25
Q

Misoprostol
Indication
Black Box

A

PGE1
Indication: cervical ripening, early pregnancy termination
Black Box: birth defect, abortion, premature birth

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26
Q

Ritodrine

Terbutaline

A

B2 selective agonist leading to uterine relaxation

- Gs

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27
Q

Atosiban
MOA
Indication

A

MOA: oxytocin receptor antagonist leading to suppression of uterine contraction
Indication: postpone labor

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28
Q

Denosumab

A

MOA: binds RANKL deceasing osteoclast
Indication: osteoporosis

29
Q

Teriparatide

Abaloparatide

A

recombinant PTH

30
Q

Bisphosphonate name

A

‘dronate

31
Q

‘dronate
MOA
Indication
Contraindication

A

MOA: dec osteoclast activity
Indication: osteoporosis
Contraindication: renal failure

32
Q

Hydrochlorothiazide
MOA
Indication
Contraindication

A

MOA: Block NCC channel inc Ca2+/Na+ channel exchanger at convoluted tubule leading to inc Ca2+ absorption
Indication: hypocalcemia, hypercalciuria

33
Q

Cinacalcet
MOA
Indication
Contraindication

A

MOA: activate CaSR receptor leading to dec PTH release
Indication: secondary hyperparathyroidism, parathyroid carcinoma
Contraindication

34
Q

ergocalciferol

A

vitamin D2 from plant

35
Q

FGF23

A

breaks down 25(OH) and 1,25(OH)

36
Q

cholecalciferol

A

vitamine D3 from sun

37
Q

calcitriol

A

1,25(OH)

38
Q

Fludrocortisone

A

mineralocorticoid replacement

39
Q

Fluocinolon

A

opthalamic steroid implant used to treat glaucoma and eye infections

40
Q

most potent anti inflammatory steroids

A

dexamethasone

betamethasone

41
Q

Metoprine MOA

A

MOA: inhibits CYP11B1 dec cortisol level

42
Q

Ketoconazole inhibits

A

17alpha hydroxylase

17,20 desmolase

43
Q

PTU
MOA
Indication
Adverse effect

A

MOA: inhibits TPO preventing thyroid hormone synthesis
Indication: hyperthyroidism
hepatitis

44
Q

thyroxine pharmacodynamics

A

take on empty stomach

45
Q

thyroxine can be used as

A

suppressant or replacement

46
Q

Potassium Iodine

A

compete w radioactive iodide for NIS transporter

47
Q

Thyroid storm treatment

A

B blockers
PTU
Glucocorticoids

48
Q

Mecasermin
MOA
Indication
Adverse Effect

A

MOA: IGF-1 analog
Indication: 2nd line for GH/IGF-1 def
Adverse Effect: hypoglycemia

49
Q

Somatotropin can treat

A

Noonan syndrome
Prader Willi Syndrome
Turner Syndrome

50
Q

Ocreotide
MOA
Indication

A

MOA: somatostatin analog
Indication: acromegaly, carcinoid tumor, VIPoma

51
Q

Pegvisomant
MOA
Indication

A

MOA: GH receptor antagonist
Indication: acromegaly

52
Q

Leuprolide
MOA
Indication

A

MOA: GnRH analog
- Intermittent: inc LH/FSH
- Continuous: dec LH/FSH
Indication: endometriosis, prostate cancer, precocious puberty

53
Q

‘relin
MOA
Indication
Adverse Effect

A

MOA: GnRH
- Intermittent: inc LH/FSH
- Continuous: dec LH/FSH
Indication: endometriosis, prostate cancer, precocious puberty

54
Q

Cosytropin
MOA
Indication

A

MOA: ACTH analog
Indication: diagnose primary vs. secondary adrenal insufficiency

55
Q

‘relix
MOA
Indication

A

MOA: GnRH antagonist
Indication: prevent premature follicular luteinization

56
Q

Zidovudine adverse effect

A

bone marrow suppression

57
Q

Thymines

A

Zidovudine and stavudine

58
Q

cause peripheral neuropathy

A

stavudine and didanosine

59
Q

avoid w patient w CAD

A

emtrcitabine

60
Q

NNRTIs names
MOA
Adverse Effects

A

MOA: non competitive inhibits reverse transcriptase
Efa: dizzy, nightmare
Entra: inducer
Nevirapine: hepatic impairment

61
Q

Protease Inhbitor name

Adverse Effects

A 
'navir
Adverser effects:
-inhibit CYP
-inc glucose, TAGs, cholesterol
-fat redistribution
62
Q

Indinavir adverse effect

A

nephrolithiasis

63
Q

Ritnavir

A

CYP inhibitor

64
Q

Enfuvirtide

MOA

A

MOA: inhibits gp41

65
Q

Maraviroc
MOA
Contraindication

A

MOA: binds CCR5 receptor
Contraindication: renal failure

66
Q

Integrase Inhibitors name

don’t give w

A

Dolutegravir
Raltegravir
don’t give w antiacids

67
Q

Drugs that will accumulate when given w protease inhibitors

A 
statins
zolams
fentanyl
amioderone
warfarin
68
Q

CYP inducers

A

rifampin

St. John’s Wart

BECOM 3 (8 decks)

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