exam 4: immunotherapy

Question 1

corticosteroids

Answer 1

immunosuppressive
blocks inflammatory/immune response

Question 2

cyclooxygenase inhibitors

Answer 2

immunosuppresive
blocks COX1 and 2 to decrease proinflammatory prostaglandins = decrease inflammation (e.g. aspirin)

Question 3

cytotoxic drugs

Answer 3

immunosuppresive
alters cell cycle progression via DNA damage or cause death of replicating cells

Question 4

cyclosporin

Answer 4

immunosuppresive
inhibits synthis of IL2 = inhibits T cell proliferation
inhibits proinflam cytokines like IL3,4 GM-CSF and TNF alpha
decreases immune cell function

Question 5

gold salts

Answer 5

general immunosuppresion like decrease macrophage function, cytokine production, T cell function, Ab production and C1

Question 6

immunoglobulins

Answer 6

immunosuppresive
blocks FcR
decrease half life of other Ab
expand Treg

Question 7

monoclonal Ab therapy

Answer 7

immunosuppresive
target growth factors or CD20

Question 8

additional immunotherapies

Answer 8

controlled administration of autoAg to induce tolerance
IgE blockade to treat allergy
gene therapy
transplantation (bone marrow)
stem cell therapy (CD34+)

Question 9

killed bacteria or plant extracts

Answer 9

enhance macrophage function
stimulates immune response

Question 10

recombinant cytokines
IL12, 18, IFN gamma?
G-CSF?
IFNalpha?

Answer 10

stimulates immune response
IL12, IL18, IFNgamma –> Th1
G-CSF –> increase neutrophils
IFNalpha –> antiviral immune response

Question 11

immunotherapy for cancer

Answer 11

proiinflam cytokines like IFN gamma
vaccination of tumor specific antigens, cytokines, inhibition of immunosuppressents
adoptive transfer of activated immune cells
immunotoxins
antibodies to block/active immune pathways
oncolytic virotherapy

Question 12

oncolytic virotherapy

Answer 12

immunostimulation
direct lysis of cancer cells

Question 13

anti-PD-L1 monoclonal Ab

Answer 13

allows immune activation because PDL1 inhibits immune function