Exam 4: Immune lymphatic system

Question 1

Innate immunity

Answer 1

Lacks specificity and memory. Response= inflammation. Neutrophils are first responders.

Question 2

Acquired immunity

Answer 2

response to antigens, more powerful than innate, longer to develop, Specificity and memory

Question 3

What are the 3 types of lymphocytes?

Answer 3

B cells (bone marrow), T-cell (thymus), NK Cells.

Question 4

What are 3 types of accessory cells or APCs?

Answer 4

Monocyte derive: macrophages and dendritic cells. Lymph node-derived: Follicular dendritic cells.

Question 5

adaptive/acquired immunity has two ways to acquire immunity:

Answer 5

1. Humoral: Antibody-mediated, plasma cells.

2. Cell-mediated immunity: (T & B cells and APCs)

Question 6

Where did the immunity of passive immunity arise from?

Active immunity?

Answer 6

1. antibodies from mom across placenta
2. antibodies of immunized animals
3. antitoxins (diptheria)

Active immunity came from T-cell (post disease)

Question 7

Define lymphoid tissue

Answer 7

appears in the body as a gradient from diffuse lymphoid tissue to aggregated lymphoid tissue to lymphoid organs.

Question 8

What are the primary and secondary lymphoid organs?

Answer 8

primary: thymus and bone marrow
Secondary: lymph nodes, spleen, tonsils
- lymphocytes originate in primary and then reside in secondary.

Question 9

T/F Mature B cells binding less strongly to a SELF-ANTIGEN survive and enter blood circulation?

Answer 9

True

Question 10

Describe lymphopoiesis

Answer 10

all immune system cells originate in bone marrow. Immature T cells travel to thymus and B-cells travel to specific regions in lymphoid tissue.

Question 11

Lymphoid stem cells generate B and T lymphocytes. Name the two T-cell lines and 3 b-cell lines

Answer 11

T cell Precursor —> T-cell

B-cell precursor —> B-cell —> plasma cell

Question 12

5 classes of Immunoglobulins (Anitbodies)

Answer 12

MADGE IgM, IgA, IgD, IgG, IgE.

Question 13

Immunoglobulins have light and heavy chains. What doe the highly variable and less variable regions contain/do?

Answer 13

Highly variable regions: Fab fragment, recognizes antigen

Less variable regions: Fc Fragment, Binds antibody to cells.

Question 14

Characteristics of MADGE

Answer 14

M: 1st antibody class expressed by developing b-cells
A: saliva, milk, GU and respiratory tracts
D: On surface of B cells traveling to lymphoid organs
G: Major Ig in blood, most antibody activity (cross placenta)
E: Associated with allergic responses

Question 15

Maturation of B cells involves the appearance of:

Answer 15

IgM & IgD & MHC II ( ForCe complement II B an MD)
Complement
Ig Fc receptors