CAMs and Junctions Flashcards
Desmocollins and Desmogleins belong to which group of CAMs?
Cadherins
Zonula occludens and Desmosomes are associated with what type of CAM?
Cadherins
What serves as a major interface between the cadherins that hold adjacent cells together and their acting cytoskeletons?
Catenins
________ bind molecules in the ECM such as fibronectin and laminin
Integrins
__________ are molecular complexes that anchor cells together and reinforce the physical integrity of tissues and the cells that cells that make up the tissue
Zonula Adherens
_______ attach one cell to the ECM and are only associated with the basal domains
Hemidesmosomes
Selectins bind to ___________
carbohydrates
Fribronectin:
glycoprotein formed by two identical chains linked by disulfide linkages close to the c-terminal.
Two forms of fibronectin.
- Cellular fibronectin: from fibroblast, forms part of ECM
2. Plasma fibronectin: from hepatocytes, secreted into bloodstream.
Binding sites on fibronectin: (4)
heparing (proteoglycan), integrins, collagen, fibrin.
What are the types of calcium dependent CAMs?
cadherins, selectins
What are the two types of calcium independent CAMs?
Integrins, immunoglobulin superfamily molecules
Ligand recognized by cadherins
other cadherins (same or different, it don’t matter)
Ligand recognized by selectins
carbohydrates
Ligand recognized by integrins
extracellular matrix molecules
Ligand recognized by Ig superfamily
integrins
E-Cadherins (a classical cadherin) are found where?
Epithelial tissues
N-Cadherins (a classical Cadherin) are found where?
Nerve cells
P-Cadherins (a classical Cadherin) are found where?
Placenta.
Desmocollins and desmogleins (nonclassical cadherins) are found where?
Desmosomes (macula adherens)
_________ are the most common type of cadherins and have a __________ binding face.
- E-cadherins 2. HVA (form homophilic dimers)
A loss of __________, can be associated with invasive behavior of tumor cells.
e-cadherins
__________ are small proteins that link the cytoplasmic end of a cadherin with cytoplasmic actin
Catenins
Integrins have how many subunits?
Two