Exam 3: Vasodilators & Tx of Angina Pectoris

Question 0

Most common CV disease in developed countries:

Answer 0

Ischemic Heart Disease

Question 1

Name 2 groups of drugs used for the prophylaxis of angina pectoris:

Answer 1

Calcium Channel Blockers and Beta Blockers

Question 2

Mainstay therapy for immediate relief of angina pectoris:

Answer 2

Organic Nitrates. Ex: Nitroglycerin

Question 3

Most common cause of angina

Answer 3

Coronary Artery Disease (CAD). Atheromatous plaque

Question 4

3 main classification of drugs used in treatment of angina pectoris:

Answer 4

Nitrates
Beta blockers
Calcium channel blockers

Question 5

Which statement is false concerning claudication?
A. Disappears with rest
B. Results from obstruction (atheroma) in large & medium arteries
C. Occurs in skeletal muscles
D. Occurs during exercise
E. Treat with vasodilators

Answer 5

E. Conventional vasodilators are useless because vessels distal to obstruction are already dilated at rest

Question 6

2 drugs used almost exclusively for peripheral artery dse:

Answer 6

Pentoxifylline: Xanthine derivative that reduces viscosity of blood
Cilostazol: PDE3 inhibitor. Probably has selective anti-platelet and vasodilating effects. MOA poorly understood

Question 7

A patient has unstable angina with recurrent ischemic episodes at rest. What is the principle cause?

Answer 7

Recurrent platelet rich non-occlusive thrombus formation

Question 8

First line therapy in treatment of CAD?

Answer 8

Reducing/stopping the risk factors like 
Smoking
HTN
Hyperlipidemia 
Obesity 
Clinical depression

Question 9

In preventing MI, what are the 2 classification of drugs given? Give best answer

Answer 9

Anti-platelets: aspirin, ADP receptor blocker

Lipid lowering agents: statins

Question 10

Antiangina drug that works by reducing late sodium current (I sub NA). Remember late sodium channel helps calcium entry by sodium calcium exchanger. Resulting in dec intracellular calcium concentration 
A. Propranolol
B. Verapamil 
C. Ranolazine
D. Atosiban

Answer 10

C

Question 11

What’s the point of using metabolic modulators like pFOX inhibitors as an antianginal drug?

Answer 11

They slightly inhibit fatty acid oxidation pathway in heart. This fatty acid oxidation uses oxygen. So by inhibiting the FA oxidation, you spare precious O2. Lessens the degree of ischemia

Question 12

Direct effect or reflex effect of nitroglycerin?
A. Dec HR
B. Dec venous capacitance
C. Inc afterload
D. In cardiac force

Answer 12

D

Question 13

Common SE of nitroglycerin:
A. Apnea
B. Diuresis
C. Headache
D. Dizziness

Answer 13

C. Throbbing headache

Question 14

Drug useful in the prophylaxis of angina: 
A. Amyl nitrate
B. Diltiazem 
C. Esmolol
D. Sublingual isosorbide dinitrate

Answer 14

B

Question 15

Beta blockers for patients with chronic angina help because they:
A. Block exercise induced tachycardia
B. Dec. end diastolic ventricular volume
C. Inc double product
D. Inc cardiac force

Answer 15

A

Question 16

The drugs prazosin and nitroglycerin have this in common: 
A. Bradycardia 
B. SLE like symptoms
C. Orthostasic hypotension 
D. Throbbing headache

Answer 16

C

Question 17

Pt comes to the ER because of a drug OD. He is hypotensive and has severe tachycardia. He has been receiving therapy for hypertension and angina. Which drug causes tachycardia?
A. Isosorbide dinitrate 
B. Clonidine
C. Propranolol 
D. Verapamil

Answer 17

A

Question 18

Man presents with SOB, brownish cyanosis appearance and hypotension. Which drug causes methemoglobinemia?
A. Amyl nitrate 
B. Isosorbide dinitrate
C. Isosorbide mononitrate 
D. Sodium cyanide

Answer 18

A

Question 19

Which drug inhibits PDE5 that inactivates cGMP? 
A. Sildenafil
B. Hydrazaline 
C. Terbutaline
D. Atenolol

Answer 19

A

Question 20

Calcium chancel blockers and beta blockers both have an effect on:
A. End diastolic cardiac size 
B. Heart rate
C. Increasing cardiac force
D. Vascular tone

Answer 20

A

Question 21

What do you give during a digoxin OD?

Answer 21

Digoxin antibodies or Digibind

Question 22

Which drug class prolongs life in CHF?
A. Beta blockers 
B. Dobutamine
C. Digoxin
D. Spironolactone

Answer 22

A

Question 23

Which drug decreases mortality in CHF patients? 
A. Beta blockers 
B. Dobutamine
C. Digoxin
D. Spironolactone

Answer 23

D