Exam 3: Drugs Used In Heart Failure Flashcards
50% of younger patients have this type of HF in which there is reduced mechanical pumping action and reduced ejection fraction
Systolic HF
Most common cause of HF in US?
Coronary Artery Disease (CAD)
This type of HF is characterized by stiffening and loss of adequate relaxation playing a major role in reduced filling and CO. Ejection fraction may be reduced even though SV is super reduced
Diastolic HF
2 goals in treatment of HF:
- Reducing symptoms & slow progression
2. Manage acute episodes of decompensated failure
In this type of HF it is believed that it is primarily due to a problem within the excitation-contraction coupling machinery of the heart
Systolic HF
In the treatment of HF, therapy directed towards non-cardiac elements are much more valuable strategies for long term management instead of the use of positive ionotropes such as digitalis. T/F?
True
Only agents in current use that actually prolong patient's life with chronic HF. There are 5. Choose the one that does not belong: A. Diuretics B. ACEI C. ARB D. Beta blockers E. Aldosterone receptor agonists F. Hydralazine nitrate
A
Which classification of drug is most useful in acute systolic failure? And give example
Positive ionotropes, cardiac glycosides like digitalis
Positive ionotropes help increase survival in chronic failure. T/F
False. They consistently reduce survival. The only positive ionotrope that doesn’t reduce survival is digitalis. But the use of other positive ionotropes is discouraged
This drug is derived from the purple foxglove plant: A. Aspirin B. Warfarin C. Digoxin D. Dobutamine
C
Bipyridines, such as Inamrione and Milrinone inhibit what? Available only parenterally and elimination half lives of 3-6 hours.
A. Inhibits PDE-1
B. Inhibits PDE-2
C. Inhibits PDE-3
C
All are MOAs of bipyridines except:
A. Vasodilator effect
B. Inhibition of PDE-3 results in inc cGMP, thus inc in contractibility & vasodilation
C. Inc calcium influx during action potential
D. Stimulate sacroplasmic reticulum to release calcium
B. It inc camp, not cGMP
This drug is a selective beta 1 agonist wildly used in the treatment of HF: A. Captopril B. Amiodarone C. Milrinone D. Dobutamine
D
Drugs primarily used in the treatment of chronic HF? Name them. There’s 5
Diuretics, ACEI, ARB, aldosterone antagonists and beta blockers
AAABD
Important drugs used in acute HF? Name them. There are 2
Diuretics and vasodilators