Exam 3 - Rochet/Campbell (Parkinsons/Alzheimer's) Flashcards
Parkinson’s Disease (PD):
it is progressive (reversible or irreversible) disease resulting in neurological deficit in the ________ system
Irreversible;
deficit in extrapyramidal
Parkinson’s Disease Symptoms?
Resting tremor Rigidty Bradykinesia Impaired balance/coordination Mask-like appearance speech difficulties, cognitive deficits
Parkinson’s Disease (PD) is characterized by a loss of _________ in the _______
dopamine neurons; in substantia nigra
what is a lewy body?
there are dense spherical protein deposits in the brain
surviving neurons in the brains of PD pt have them
where are lewy bodyies found in PD pt?
in the substantia nigra and other parts like cortex
Lewy bodies are enriched with what things?
fibrillar forms of protein alpha-synuclein
what are the Braak stages?
way to stage Parkinsons;
based on “alpha-synuclein neuropathology”
how many braak stages are there
6
Stage 1 of Braak – means neuropathology starts in ______
lower brainstem
List Stages 1 - 6 of Braak Stages
1 - lower brainstem (starts here and ascends!) 2 - Raphe 3 - Substania Nigra 4 - Mesocortex/Thalamus 5 - Neocortex/Prefrontal Cortex 6 - Entire Neocortex
Environmental poisons that are linked to increased PD risk happen because they do what?
they inhibit mitochondrial function and/or trigger oxidative stress
what are examples of environmental poisons that are linked to Parkinson’s Disease (PD)
- Pesticides
- Herbicides
- Metals (manganese)
- MPTP (a heroin contaminant, complex I inhibitor)
Basal ganglia is made up of the ________ and ______
striatum and globus pallidus
The striatum is made of ______ and _____
caudate nucleus; putamen
the globus pallidus is broken into what?
GPi and GPe
Globus pallidus internal and globus pallidus external
Dopamine Neurons and Pathways:
Indirect pathway involves D1 or D2 receptors?
D2
Dopamine Neurons and Pathways:
Direct pathway involves D1 or D2 receptors?
D1
Dopamine Neurons and Pathways:
D1 receptor works through direct or indirect pathway?
direct
Dopamine Neurons and Pathways:
D2 receptor works through direct or indirect pathway?
indirect
what is an antimuscarinic that be used as adjunct therapy in PD
benzotropine
why are antimuscarinics used as adjunct therapy in parkinsons?
when dopamine decreases — the cholinergic pathway ramps up (aka chill out that pathway by using anticholinergics)
what is the “gold standard” for PD therapy
L-DOPA
why cant we give dopamine directly?
dopamine has a + charge and cant enter CNS;
L-DOPA = no charge = CAN enter CNS!
what can be added to L-DOPA as a regimen to decrease the dose of L-DOPA needed
add carbidopa
why does giving carpidopa lead to a lesser dose of L-DOPA being needed
Carbidopa inhibits DCC (aka L-DOPA does not turn to Dopamine)
L-DOPA —(what enzyme?)–> Dopamine
DCC (DOPA decarboxylase)
T or F: Carbidopa can cross the blood brain barrier
FALSE!
it can NOT cross BBB – aka cannot inhibit DCC in the SN
what is definition of dyskinesias
exaggerated/aberrant motor effects
L-DOPA Therapy:
__________ are seen immediately after dosage of L-DOPA
Dyskinesias
to prevent dyskinesias and the on/off effect it is best ot give L-DOPA in a ______ manner
continuous manner!!
pulsatile is crap
L-DOPA Therapy:
a key limitation is associated with _________; this becomes a bigger issue when the patients get older/the disease progresses
prodrug conversion
as disease progresses — pts become less responsive to L-DOPA because they cant convert it to dopamine as easily
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
Apomorphine
DA receptor agonist
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
Ergoline drug class
Dopamine receptor agonist
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
Bromocriptine
DA receptor agonist (it is an ergoline)
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
Pergolide
DA receptor Agonist (it is an ergoline)
What drugs are ergolines
Bromocriptine
Pergolide
Cabergoline
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
Non-Ergoline Drug Class
DA receptor agonist
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
Ropinirole
DA receptor agonist - it is an NON-ergoline
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
Rotigotine
DA receptor agonist - it is an NON-ergoline
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
Pramipexole
DA receptor agonist - it is an NON-ergoline
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
MAO-B inhibitors
inhibit metabolism
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
Selegiline
inhibit metabolism (MAO-B inhibitors)
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
Rasagiline
inhibit metabolism (MAO-B inhibitor)
Dopamine Agonist or Inhibitor of Dopamine Metabolism?
Safinamide
inhibit metabolism (MAO-B inhibitor)