Exam 3 - Random Info Flashcards
when Mn = Mw and polydispersity (Mw/Mn) is 1, this is classified as
a. monodispersed
b. polydispersed
a. monodispersed
When Mw»_space; Mn and polydispersity (Mw/Mn)»_space; 1, this is classified as
a. monodispersed
b. polydispersed
b. polydispersed
polymer can pack together in regular arrays at T < Tm. This describes
a. crystalline
b. amorphous
a. crystalline
polymers with irregular structure describes
a. crystalline
b. amorphous
b. amorphous
which is easier to dissolve, crystalline or amorphous polymers?
amorphous
(amorphous is more common)
what is glass transition temperature?
temp range where a polymer changes from a hard, “glassy” state to a more pliable, “rubbery” state
at T «_space;Tg, polymers are
a. hard, stiff, and glassy
b. rubbery and may flow
a. hard, stiff, and glassy
at T»_space; Tg, polymers are
a. hard, stiff, and glassy
b. rubbery and may flow
b. rubbery and may flow
longer polymers, longer side chains, and more crosslinking leads to a _____ Tg (glass transition temp)
a. lower
b. higher
b. higher
what are plasticizers?
molecules that inc entropy and mobility of the polymer chains
do plasticizers raise or lower Tg when included in polymer products?
lower
if T «_space;Tg of polymer, how is drug release rate affected?
rate would be slower
mechanical properties of polymers: stiffness is represented by ?
slope (stress/strain)
(greater the modulus, greater the stiffness)
mechanical properties of polymers: toughness is represented by ?
area under the curve
true or false: hydrogels retain large volume of water in their structures
true
the _____ domain of mAbs helps determine biodistribution and plasma half-life
a. variable
b. constant
b. constant
what is an antibody drug conjugate (ADC)?
these combine target specificity of mAb with efficacy of small molecule drug
3 insulin analogs we talked about
lispro insulin (Humalog)
insulin aspart (Novolog)
insulin glargine
peptides are usually less than ___ amino acids
50
first approved CAR-T therapy
Kymriah
Spinraza (nusinersen) is a modified antisense oligonucleotide that is used to treat what?
spinal muscular atrophy
_____ provides the gel-like structure of mucus
mucin
mucin carries a negative charge due to high content of _____ _____ (sugar)
sialic acid
which is more permeable: gingiva and buccal mucosa, or the floor of the mouth and ventral side of the tongue?
floor of the mouth and ventral side of the tongue