Exam 3(pre-ME3) Flashcards
What adaptations have pathogens started using for success?
Pain, lethargy, necrosis
Virulence
spectrum of bacterial harmfulness, avirulent=not harmful
Factors
bacterial genes that can cause harm, often proteins, depends on microbe’s genome and proteome
what type of gene transfer is conjugation?
horizontal gene transfer
Purpose of virulence factors
gain access to nutrients from host
Purpose of biofilms
help organisms stay in one place
Strategy of pathogens in hosts
adhesion, invasion, colonization/growth, tissue damage/disease
what strategies of pathogens in hosts don’t always occur?
invasion and tissue damage/disease
Ice nucleation
some bacteria can produce proteins(INPs) that serve as ice nucleators, they form ice crystals at lower temps, water freezes around the protein at warmer temps
Proteases, lipases, nulceases
break down lipids, proteins and nucleic
Collagenase
breaks down collagen, gas gangrene
Clostridium
genus that is endospore producing, anaerobic organisms
Streptokinase
causes strep throat, scarlet fever and necrotizing fasciitis, dissolves fibrin
fibrin
a connective tissue, forming a large cable to holding things together
post-debridement
removal of dead tissue
Coagulase
causes blood to clot, white blood cells struggle to get to bacteria to fight them
What do staph infections do?
they cause blood to clot with cuagulase
endotoxins+examples
not actively secreted, general symptoms, LPS of gram negative bacteria, part of outer gram negative membrane, less toxic than exotoxins
Exotoxins+examples
secreted, very specific targets, A-B, cytolytic, super antigen, botulinum, tetanus, more toxic than endotoxins
What affect does LPS have on the immune system?
Sepsis or septic shock
What do large doses of endotoxin cause?
Hemorrhagic shock, tissue necrosis
Botulinum toxin
exotoxin, produced by clostridium botulinum, most acutely lethal toxin known, obligate anaerobe, antibiotics often can’t help, come from improperly preserved foods and spores in honey, block acetylcholine(AC) that causes muscle to contract, often causes death from not being able to breathe, tiny amounts used in botox
Tetanus toxin
produced by clostridium tetani, obligate anaerobe, come from puncture wounds, released from site of growth
Why are deep tissues beneficial to some bacteria?
they are anaerobic environments where endospores can germinate