Exam 3 Practice Questions Flashcards

1
Q

Who observed the possible relationship between the cowpox virus and smallpox virus, developing the first vaccination?

A

Edward Jenner

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2
Q

How are viruses grown in the laboratory?

A

in chick embryos

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3
Q

What is a capsid, with regard to viral structure?

A

the protein layer enclosing viral genome

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4
Q

What is the function of a glycoprotein in the viral envelope?

A

to allow a virus to attach to a host cell

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5
Q

A capsid that has icosahedral symmetry results in a virus with a ___________ shape.

A

Spherical

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6
Q

Which of the following is considered a spongiform encephalopathy?

Select one:

a. kuru
b. Chagas disease
c. parkinson’s disease
d. Huntington’s disease

A

Kuru

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7
Q

A bacteriophage attaches to its host cell during which phase of replication?

Select one:

a. Adsorption
b. Penetration
c. Maturation
d. Release

A

Adsorption

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8
Q

When viruses remain in a cell for a prolonged period of time, this is referred to as a _______________ infection.

A

Persistent

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9
Q

What portion of an enveloped virus binds to the host cell?

A

Glycoproteins

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10
Q

Which type of RNA virus has a nucleic acid composition that can immediately serve as mRNA?

A

positive strand RNA viruses

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11
Q

Retroviruses produce double stranded DNA from RNA. What name is given to the double stranded DNA molecule?

A

Proviral DNA

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12
Q

Bacteriophage DNA is injected into the host cell during which phase of replication?

Select one:

a. Adsorption
b. Penetration
c. Maturation
d. Release

A

Penetration

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13
Q

New viral assembly occurs during which phase of replication?

Select one:

a. Adsorption
b. Penetration
c. Maturation
d. Release

A

Maturation

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14
Q

What enzyme is produced to allow viral release from the host bacterial cell?

Select one:

a. Lysozyme
b. Catalase
c. Perioxidase
d. Amylase

A

Lysozyme

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15
Q

Following replication, how does a naked virus typically exit the cell?

A

by lysis

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16
Q

Viral transformation may lead to:

A

cancer

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17
Q

What is the name of the virus that causes smallpox?

A

variola

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18
Q

About how many cases of smallpox occurred globally in 2015?

A

None

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19
Q

Small flesh colored bumps are characteristic of which pox virus?

A

molluscum contagiosum

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20
Q

Which pox virus is used to vaccinate for smallpox?

A

vaccinia

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21
Q

Which poxvirus typically causes lesions on the hands and fingers?

A

orf

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22
Q

What is the most common route of transmission of CMV?

A

sexual contact

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23
Q

In AIDS patients CMV can cause ______________.

A

retinitis

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24
Q

What are the two routes of transmission for the varicella zoster virus?

A

direct contact with vesicle fluid

respiratory secretions

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25
Q

What is the site of latency for the VZV virus?

A

neurons

26
Q

Which of the following conditions is characterized by a rash in a single dermatome?

A

shingles (zoster)

27
Q

Infections due to HSV-1 are typically:

A

the oral cavity

28
Q

Infections due to HSV 2 are typically:

A

genital infections

29
Q

The lesions known as herpetic whitlow are frequently observed on:

A

the fingers

30
Q

Who contracts herpes gladiatorum?

A

wrestlers

31
Q

What is the site of latency for the Epstein-Barr virus?

A

B lymphocytes

32
Q

An overactive immune response to EBV results in which pathology?

A

mononucleosis

33
Q

Lack of immune response to EBV results in which pathology?

A

lymphoma

34
Q

What is the mode of transmission of EBV?

A

oral secretions

35
Q

Roseola is due to infection with:

A

HHV 6

36
Q

A child with a fever that persists for 3 days develops a rash that does not itch. What is the likely diagnosis?

A

roseola

37
Q

HHV 8 is responsible for:

A

Kaposi’s sarcoma

38
Q

Which of the following is a common way to contract a human papillomavirus infection?

Select one:

a. sexual contact
b. fecal- oral transmission
c. respiratory transmission
d. injection drug use

A

sexual contact

39
Q

Some strains of HPV can transform cells leading to _______________.

A

cervical cancer

40
Q

Common warts seen on the hands or fingers are typically the result of HPV ____________________.

A

on contaminated articles like towels

41
Q

Viruses known as JC and BK are which type of viruses?

A

polyomavirus

42
Q

Fifth disease, also sometimes called “slapped cheek” disease is caused by ________________.

A

parvovirus

43
Q

What is the function of the N (neuroaminidase) glycoprotein spike?

A

to aid in viral exit from the host cell

44
Q

What is the function of the H (hemagglutinin) glycoprotein spike?

A

to allow the virus to attach to the host cell

45
Q

What is the mode of transmission for the rubeola (measles) virus?

A

respiratory

46
Q

On of the hallmarks of measles is the whitish patches inside the oral cavity, what are these mucosal patches called?

A

Koplick’s spots

47
Q

Encephalitis is an occasional complication of which of the following viruses, occurring in approximately 1 in 1000 cases?

A

rubeola virus

48
Q

Parainfluenza viruses are responsible for which of the following conditions?

A

croup

49
Q

Mumps is an infection of the ________________

A

salivary glands

50
Q

What is the mode of transmission for the mumps virus?

A

respiratory

51
Q

Orchitis is a somewhat common complication of mumps. What is orchitis?

A

testicular swelling

52
Q

What is the mode of transmission for the rubella virus?

A

respiratory

53
Q

A baby born with hearing loss, mental retardation and heart defects may be suffering from:

A

congenital rubella

54
Q

A 31 years old male patient who is HIV + complains of fever and loss of peripheral vision. A blood specimen is submitted to detect viral antigen. Which virus is likely causing these symptoms?

A

CMV (cytomegalovirus)

Can cause retinitis in the eye of up to 15% of AIDS patients

55
Q

A 72 year old woman complains of a burning, painful rash on her chest. A physical exam reveals a vesicular rash limited to the dermatomal area of T7-T8. What is the likely diagnosis?

A

HZV

Latent varicella virus in neurons is reactivated

56
Q

A 22 year old sexually active man complains of warts on his penis. The man is tested fro HPV, in addition to his female partner. What might she be at risk for developing is she is positive?

A

Cervical cancer

57
Q

A 19 year old college student presents with fever, very painful sore throat and headache. Physical exam reveals enlarged lymph nodes and a slightly enlarged spleen. What virus might be responsible for this?

A

Epstein Barr virus

Becomes latent in B cells

58
Q

At a preferment evaluation, a 31 year old pregnant woman reports pain on urination and a burning itching sensation in the genital area. What virus is most likely causing these symptoms?

A

HSV-2 (could also be HSV 1 but unlikely)

She should not have a vaginal delivery

59
Q

A 16 year old male present with tenderness and swelling of the left testis. He also reports difficulty swallowing and on exam, his salivary glands are enlarged. What virus is causing his symptoms?

A

Mumps

60
Q

A 20 year old college student presents with fever, cough and conjunctivitis. Physical exam reveals pale patches in the oral mucosa and a rash on her face, spreading to her trunk. She is unvaccinated due to personal beliefs, What is her likely diagnosis?

A

Measles (disease) which is cause by infection with rubeola (virus)