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AU14 Drug Mechanisms > Exam 3; Mechanisms > Flashcards

Exam 3; Mechanisms Flashcards

1
Q

quinidine

A

anti-arrhythimic (Class Ia)

Na+ channel blocker

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2
Q

procainamide

A

anti-arrhythimic (Class Ia)

Na+ channel blocker

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3
Q

disopyramide

A

anti-arrhythimic (Class Ia)

Na+ channel blocker

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4
Q

lidocaine

A

anti-arrhythimic (Class Ib)

Na+ channel blocker

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5
Q

mexiletine

A

anti-arrhythimic (Class Ib)

Na+ channel blocker

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6
Q

metoprolol

A

anti-arrhythmic (Class II)

beta 1 blocker

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7
Q

propranolol

A

anti-arrhythmic (Class II)

beta 1 blocker

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8
Q

esmolol

A

anti-arrhythmic (Class II)

beta 1 blocker

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9
Q

sotalol

A

anti-arrhythmic (Class III)

K+ channel blocker, beta 1 blocker

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10
Q

amiodarone

A

anti-arrhythmic (Class III)

All four! Na+ channel blocker, beta 1 blocker, K+ channel blocker, Ca++ channel blocker

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11
Q

dronedarone

A

anti-arrhythmic (Class III)

All four! Na+ channel blocker, beta 1 blocker, K+ channel blocker, Ca++ channel blocker

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12
Q

verapamil

A

anti-arrhythmic (Class IV)

Ca++ channel blocker

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13
Q

diltiazem

A

anti-arrhythmic (Class IV)

Ca++ channel blocker

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14
Q

nifedipine

A

anti-arrhythmic (Class IV)

Ca++ channel blocker

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15
Q

adenosine

A

anti-arrhythmic

binds to adenosine receptor, decreasing firing rate of AV node

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16
Q

GTN (glyceryl trinitrate)

A

aka nitroglycerin
treats angina
activates NO –> guanylate cyclase

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17
Q

isosorbide dinitrate

A

treats angina

activates NO –> guanylate cyclase

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18
Q

digoxin

A

treats CHF, inotropic

inhibits Na+-K+-ATPase

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19
Q

dobutamine

A

treats CHF, inotropic

beta 1 agonist

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20
Q

tadalafil

A 
treats ED
inhibits enzyme (Type 5 cGMP phosphodiesterase)
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21
Q

varedenafil

A 
treats ED
inhibits enzyme (Type 5 cGMP phosphodiesterase)
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22
Q

avanafil

A 
treats ED
inhibits enzyme (Type 5 cGMP phosphodiesterase)
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23
Q

sildenafil

A 
treats ED
inhibits enzyme (Type 5 cGMP phosphodiesterase)
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24
Q

alprostadil

A

treats ED

injectable prostaglandin E1

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25
Q

citric acid

A

anti-coagulant

Ca++ chelator

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26
Q

EDTA

A

anti-coagulant

Ca++ chelator

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27
Q

EGTA

A

anti-coagulant

Ca++ chelator

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28
Q

heparin

A

anti-coagulant

activates anti-thrombin

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29
Q

dalteparin

A

anti-coagulant

activates anti-thrombin

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30
Q

enoxaparin

A

anti-coagulant

activates anti-thrombin

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31
Q

fondaparinux

A

anti-coagulant

activates anti-thrombin

32
Q

hirudin

A

anti-coagulant

inhibits thrombin

33
Q

bivalirudin

A

anti-coagulant

inhibits thrombin

34
Q

desirudin

A

anti-coagulant

inhibits thrombin

35
Q

argatroban

A

anti-coagulant

inhibits thrombin

36
Q

warfarin

A

oral anti-coagulant

inhibits enzyme that recycles/resynthesizes vitamin K

37
Q

dabigatran

A

oral anticoagulant

inhibits thrombin directly

38
Q

rivaroxaban

A

oral anticoagulant

inhibits factor Xa

39
Q

apixaban

A

oral anticoagulant

inhibits factor Xa

40
Q

vorapaxar

A

platelet inhibitor

thrombin receptor blocker

41
Q

ticagrelor

A

platelet inhibitor

ADP receptor blocker

42
Q

ticlopidine

A

platelet inhibitor

ADP receptor blocker

43
Q

prasugrel

A

platelet inhibitor

ADP receptor blocker

44
Q

clopidogrel

A

platelet inhibitor

ADP receptor blocker

45
Q

abciximab

A

platelet inhibitor

fibrinogen receptor blocker

46
Q

eptifibatide

A

platelet inhibitor

fibrinogen receptor blocker

47
Q

tirofiban

A

platelet inhibitor

fibrinogen receptor blocker

48
Q

aspirin

A

platelet inhibitor
COX enzyme inhibitor
(inhibits TXA2 synthesis)

49
Q

cilostazol

A

platelet inhibitor

phoshodiesterase enzyme inhibitor

50
Q

dipyridamole

A

platelet inhibitor

phoshodiesterase enzyme inhibitor

51
Q

anagrelide

A

platelet count reducer

52
Q

TPA = tissue plasminogen activator

A

thrombolytic agent

convert plasminogen –> plasmin

53
Q

streptokinase

A

thrombolytic agent

convert plasminogen –> plasmin

54
Q

urokinase

A

thrombolytic agent

convert plasminogen –> plasmi

55
Q

aminocaproic acid

A

hemostatic agent

inhibit plasminogen activation

56
Q

tranexamic acid

A

hemostatic agent

inhibit plasminogen activation

57
Q

epoietin alfa

A

to treat anemias due to chronic renal failure or chemotherapy
erythropoietin agent

58
Q

peginesatide

A

to treat anemias due to chronic renal failure or chemotherapy
erythropoietin agent

59
Q

darbepoietin

A

to treat anemias due to chronic renal failure or chemotherapy
erythropoietin agent

60
Q

hydroxyurea

A

to treat sickle cell anemia

inc formation of fetal hemoglobin

61
Q

“statin”s

A

hypolipidemic agent
best to dec LDL
inhibits HMG-CoA reductase enzyme

62
Q

niacin

A

hypolipidemic agent
aka vitamin B3, nicotinic acid
best to inc HDL
inhibits enzyme + binds receptor

63
Q

coleseleuam

A

hypolipidemic agent

bile acid binding resin –> excret cholesterol

64
Q

colestipol

A

hypolipidemic agent

bile acid binding resin –> excret cholesterol

65
Q

cholestyramine

A

hypolipidemic agent

bile acid binding resin –> excret cholesterol

66
Q

gemfibrozil

A

fibrates, hypolipidemic agent
best to dec triglycerides
bind PPAR (activating receptor) –> inc lipoprotein lipase

67
Q

fenofibrate

A

fibrates, hypolipidemic agent
best to dec triglycerides
bind PPAR (activating receptor) –> inc lipoprotein lipase

68
Q

icosapent ethyl

A

fish oil, hypolipidemic agent

inhibits enzyme –> dec triglyceride synthesis

69
Q

omega 3 fatty acids

A

fish oil, hypolipidemic agent

inhibits enzyme –> dec triglyceride synthesis

70
Q

lomitapide

A

hypolipidemic agent
enzyme and transporter
inhibits VLDL assembly in liver

71
Q

mipomersen

A

hypolipidemic agent

binds mRNA for apolipoprotein –> prevents APO synthesis

72
Q

ezetimibe

A

hypolipidemic agent

blocks chol transporters in gut –> dec chol absorption

73
Q

sitostanol

A

hypolipidemic agent

blocks chol uptake (looks like chol)

74
Q

orlistat

A

hypolipidemic agent

inhibits GI + pancreatic lipase enzymes

75
Q

olestra

A

hypolipidemic agent

oil is not absorbable

AU14 Drug Mechanisms (7 decks)

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