Exam 3 Material Flashcards
Which of the following accurately describes the olfactory system:
Odorant molecules bind to receptors on the mitral cells in the olfactory bulb
, Not Selected
The olfactory epithelium is a part of the olfactory bulb
, Not Selected
Olfactory sensory neurons are arranged topographically in the epithelium, but its axons project randomly onto mitral cells
, Not Selected
Correct answer:
Olfactory sensory neurons synapse with mitral cells in the glomeruli within the olfactory bulb
Olfactory sensory neurons synapse with mitral cells in the glomeruli within the olfactory bulb
The total inability to smell, most often resulting from sinus or viral infection or physical damage from an accident, is known as
Agnosia
, Not Selected
Parosmia
, Not Selected
Hyposmia
, Not Selected
Correct answer:
Anosmia
Anosmia
Which of the following is FALSE regarding the olfactory transduction cascade
Golf activates the enzyme adenylate cyclase
, Not Selected
Adenylate cyclase raises intracellular cyclic AMP (cAMP)
, Not Selected
Correct answer:
Activation of the olfactory receptor by an odorant results in a membrane hyperpolarization
Rising cAMP levels opens cAMP-gated ion channels that allow Na+ and Ca2+ to enter the cell
, Not Selected
Binding of a “preferred” odorant to olfactory receptor molecule activates the G-protein Golf
Activation of the olfactory receptor by an odorant results in a membrane hyperpolarization
Activation of the olfactory receptor by an odorant results in a membrane hyperpolarization
Chemoreception
the detection of chemicals using olfactory sensory cells
Olfaction
sniffing in and perceiving odors
through our nostrils
Orthonasal olfaction
exhaling odorant molecules into
our mouth, where they can travel up into our upper nasal cavity
Retronasal Olfaction
Odorant
a molecule that can be smelled
Olfactory Bulb
a neural structure of the vertebrate forebrain
involved the sense of smell
Glomeruli
Discrete spheres of nerve tissue; formed from
the axons of the olfactory sensory neurons and dendrites of
mitral cells
Mitral Cells
Interneurons in the olfactory bulb, whose axons
pass information to other parts of the brain
Volatile
a molecule that is
buoyant in air and can
be inhaled
Turbinates
curled bony protrusions that create turbulence to
incoming air
Olfactory Epithelium
mucus membrane in the roof of the nasal
cavity that houses the olfactory sensory neurons (OSNs)
Olfactory Sensory Neurons (OSNs)
a transduction cell within the
olfactory epithelium
small neurons in
the mucous layer of the olfactory epithelium that
contain the receptor sites for odorant molecules
Olfactory Receptor Molecules
A large family of G-protein coupled
receptors that are expressed in the cilia of olfactory sensory neurons and
bind to odorants
Olfactory sensory neurons can be _______________ regularly throughout
adulthood
Replaced
Olfactory Transduction Cascade
A series of events that starts with a
chemical (odorant) binding to the olfactory receptor molecule and ends
with a change in the membrane potential of an olfactory sensory neuron
Each odorant activates only a _________ of olfactory sensory neurons
Subset
Chemotopy
Orderly mapping between odorant structure and spatial
location of activated glomeruli
Mitral Cells receive input
from just________
one glomerulus
Granule Cell
most numerous type of neuron in the olfactory bulb and
interconnect mitral cells; do not have axons
Reciprocal dendro-dendritic synapses
synapses between dendrites that are
arranged so that a synapse that transmits signals in one direction, lies adjacent to
a synapse going in the other direction
Shutting down activity shortly after it has begun likely keeps
the system sensitive to ________________ odors
new or changing
Lateral inhibition
The process by which nearby neurons inhibit each
other
Anosmia
the total inability to smell, most often
resulting from sinus or viral infection or physical damage from an
accident
If the bony plate scars over,
regenerated OSN axons cannot
________ to the olfactory bulbs
connect
Hyposmia
significantly reduced sense of smell
Parosmia
a distorted sense of smell
Olfactory nerve
axons of the olfactory sensory neurons
bundle together to form the first cranial nerve
OSN axons are among the ________ and the _________ in the
body
Thinnest; slowest
Olfactory bulb
first relay for olfactory sensory neurons in the brain
Axons of the mitral cells and other neuron types in each bulb
combine to form the _______________
Olfactory tract
Olfactory cortex (piriform cortex)
a set of cortical areas that receives
highly divergent input from neurons in the olfactory bulb (involved in odor
discrimination)
Limbic System
a group of neural structures that is involved in
many aspects of emotion and memory
Connections from the olfactory bulb to the olfactory cortex is that
they are ________________ and highly divergent
Non-topographic
Epitope
a feature of an odorant to which an olfactory receptor
may bind selectively
Each natural odor activates a variety of olfactory sensory neurons,
which activates a specific set of ______________
Glomeruli
Humans have approximately 350-400 or so different functional
_________________ that code for a different olfactory
receptor
odorant receptor genes
Olfactory receptor genes have about _____ “pseudogenes”
425
The more copies of a receptor an individual has, the more
_____________ they will be to certain odorants
sensitive
Genes associated with olfactory receptor expression
determines our ____________ to four other food relevant odors
(e.g. banana, beer, blue cheese, violets)
sensitivity
Whether you have a pseudogene or a functional
gene for a given odor can alter _______________
Odor perception
Most odorants stimulate the _______________ system to some
degree through free nerve endings within the nose
somatosensory
These sensations are mediated by the
_______________(cranial nerve V)
trigeminal nerve (cranial nerve V)
Shape pattern theory
different scents activate different arrays
of olfactory receptors in the olfactory epithelium as a function of
odorant-shape to OR-shape fit
Odorant molecules have different ___________ and an odorant
will be detected by a specific OR to the extent that the
odorant’s molecules fit into that OR
shapes
Chemicals of specific shapes fit receptors with shapes that best
_________________ them
accommodate
Different scents activate different __________ of olfactory receptors in
the olfactory epithelium, producing specific ______________ in the
olfactory bulb
arrays; glomerular activity
Can be modulated according to the ___________________ of the
individual (e.g. hunger, past experience)
physiological state
The granule cells receive ________________ projections from the
olfactory cortex
Descending
Our ability to detect, remember and odor, and recall an odor
can be manipulated by ___________________
experience
Each olfactory receptor is coded for by a ___________
specific gene
Placticity
the quality of being easily shaped or molded
______________ between neurons can and does change with
experience
Connections
HEBB’S RULE
Neurons that fire together wire together
Hebbian Long term plasticity
a strengthening of
connections between neurons that follow’s Hebb’s rule
Simultaneously activation of a subset of olfactory cortex neurons will
tend to _____________ the connection between these neurons
strengthen
Cell assemblies
weakly interconnected group of neurons that is
repeatedly co-activated will over time become strongly interconnected
(synaptic plasticity)
After an odorant binds, olfactory receptors retreat into the cell body
and are no longer _______________ to respond to the bakery scent
molecules
Physically available
Receptor adaptation
the biochemical phenomenon that occurs after
continual exposure to an odorant
Cognitive haituation
after long term exposure to an odor
ne no longer has the ability to detect that odor or has
diminished detection capability
Our ability to detect odorants declines with ___________
age
By age 85, ~50% of the population has become __________
anosmic
Alzheimer’s disease
a
neurodegenerative disease that is
associated with progressive dementia
and the loss of synapses (and
eventually neurons) in diverse brain
regions
__________________ will show up as
a deficit in early stages of
Alzheimer’s
Identifying odors
Parkinson’s
a neurodegenerative disease caused mainly by
nerve cell damage in the brain, which causes dopamine levels to
drop
A
Nasal Cavity
B
Olfactory Cleft
C
Olfactory Epithelium
D
Turbinates
E
Olfactory Sensory Neurons (OSNs)
F (F=specific structures on E. that express the olfactory receptors)
Cilia
G
Olfactory Epithelium
H
Glomerulus
I
Mitral Cells
J
Olfactory Bulb
K (where axons of I. project)
Olfactory Cortex
Fill in the blanks of the steps involved in auditory transduction
Step 1: An odorant binds to a “preferred” __________________ molecule.
Odarebt
Fill in the blanks of the steps involved in auditory transduction
Step 2: This binding activates the G-protein ____________.
G-olf
Fill in the blanks of the steps involved in auditory transduction
Step 3: One of subunits of the g-protein disassociates and activate the enzyme
_________________.
Adenylate Cyclase
Fill in the blanks of the steps involved in auditory transduction
Step 4: The activated enzyme raises intracellular levels of the second messenger
____________
cAMP
Fill in the blanks of the steps involved in auditory transduction
Step 5: This increase in the second messenger above causes __________ -gated
channels to (circle one) open / close.
cAMP; open
Fill in the blanks of the steps involved in auditory transduction
Step 6: _______ & _______ ions can enter the cell.
Na+; Ca2+
Fill in the blanks of the steps involved in auditory transduction
Step 7: This change in ion flux due to an odorant binding results in a membrane (circle
one): depolarization / hyperpolarization of the olfactory sensory neuron.
Depolarization
What best explains how and why we remember odors?
With repeated odor exposure, cortical neurons become “wired together”
The shape-pattern theory of olfaction is based on the idea that
odorants’ shapes fit into the olfactory receptors’ shapes
What is a major difference between olfactory projections vs. visual or somatosensory projections?
Projections to the olfactory cortex are non-topographic and highly divergent
Axons of the olfactory sensory neurons (OSNs) bundle together to make up the:
olfactory nerve (nI)
If your glossopharyngeal nerve (nIX) was cut, where do you predict you would lose taste sensation?
At the posterior part of the tongue
The neurotransmitter released at the synapse between taste cells and gustatory axons in the taste pathway is:
ATP
When a taste molecule binds to a T1 or T2 receptor, which intracellular signaling cascade occurs?
The g-protein gustducin decouples & activates Phospholipase C, increasing IP3 in the cytosol
Taste
sensations evoked by solutions in the mouth that
contact receptors in the tongue (and roof of the mouth) that then
connect to axons in Cranial Nerves VII, IX, and X
Liking “sweet” is hardwired into our brains, but we learn to
like the chocolate flavor of the cookie based on _______
experience
Flavor
the combination of true taste (sweet, salty,
sour, bitter) and retronasal olfaction
Retronasal olfaction
exhaling odorant molecules into our
mouth, where they can travel up into our upper nasal cavity
Retronasal olfaction is attributed to food and is combined with taste
sensations to create “_______________.”
flavor
Gustation
The sense of taste
Taste bud
a globular
cluster of cells that has the function
of creating neural signals conveyed
to the brain by taste nerves
Embedded in _____________ (gives
the tongue its bumpy appearance)
Papillae
Taste Cell
A cell
within the taste bud that
contains sites on its apical
projections that can interact
with taste stimuli
When a TRC comes in contact with one
of its ______________ molecules, it
creates a message that travels along
one of three cranial nerves to the brain
Preferred
Plotted curves to show how _________________ varied across
tongue locations in 5 participants
Taste Qualities
Appeared to show dramatic differences in _____________ to
those four major tastes across the tongue
Sensitivity
Thresholds only showed the _______________ detectable taste
concentrations rather than tastes experienced in the real world
Lowest
Taste cells encoding each of the basic
tastes are distributed _____________
the tongue
throughout
Gustutory Transduction
the process by which taste receptor
cells convert tastants into electric impulses and send them to the
brain so we can interpret them as tastes
Tastant
any stimulus that can be tasted
_____ play a role in the gustatory transduction cascade
Tastants
Salty
Taste quality produced by cations of salt
(NaCl)
Sour
Taste quality produced by the hydrogen
ion in acids
Bitter
Unpleasant taste quality produced by
substances like quinine or caffeine
Sweet
Taste quality produced by some sugars
(glucose, fructose, and sucrose)
Umami
Taste quality associated with savory
flavors
Taste Receptor
a molecule that can bind to one of more tastant and
trigger an intracellular response that ultimately cause the cell expressing
this receptor to change its membrane potentia
T1 receptor family
Sweet, Umami
T2 receptor family
Bitter
Mutant mice that lack a functional
_______________ gene lose
responsiveness to sweet, umami,
and bitter stimuli
TRP-M5
The _______________ of these T1 receptors makes us sense a particular
taste
Combination
Heterodimer
Chain of two molecules (a dimer) that are different from each other (hetero)
____________ + ____________ receptors makes cells sensitive to umami-
tasting amino acids (glutamate and aspartate)
T1R1 + T1R3
Monosodium Glutamate (MSG)
A potent flavor enhancer that activate
the T1R1/T1R3 taste receptor combination, which generates umami taste
Diversity of T2 receptors is typically ___________ used for taste
discrimination but to warn us before we ingest potentially harmful
compounds
not
Most taste cells synapse
directly onto the peripheral
endings of _____________
axons
gustatory
Principle transmitter at these
synapses is adenosine
triphosphate (________)
ATP
Pax Channel
An Ion Channel that is activated by ATP
and expressed at postsynaptic sites in gustatory axons
Insular cortex (gustatory cortex)
the primary cortical
processing area for taste
Major taste pathways:
i: Glossopharyngeal Nerve (nIX)
innervates the posterior
part of the tongue
Major taste pathways:
j: Vagus Nerve (nX)
innervates taste buds on the roof of the mouth and back of the throat
Major taste pathways:
k: Facial Nerve (nVII)
innervates taste buds on the anterior tip of the tonge.
Major taste pathways:
The sensory afferents carried by these 3 cranial nerves synapse in the l. ________________ of
the medulla oblongata
Nucleus Tactus Solitarius
Steps involved in gustatory transduction:
- A tastant molecule binds to the _______or _______ receptors.
T1 or T2