Exam 2 Flashcards
A (alpha) Fibers
Carry information from proprioceptive
receptors in muscles and tendons
A (alpha) Fibers
Carry information from proprioceptive
receptors in muscles and tendons
A (bravo) Fiber
Carry information from the mechanoreceptors
in the skin on pressure and vibration
A (delta) Fibers
Carry information about pain and temperature
C Fibers
Carry information about pain, temperature,
and itch
A (alpha) Fibers
- Thickest axons (13-20 μm)
- Myelinated
A (bravo) Fibers
- Thick axons (6-12 μm)
- Myelinated
A (delta) Fibers
- Thin axons (1-5 μm)
- Myelinated
C Fibers
- Thinnest axons (0.2-1.5 μm)
- Unmyelinated axons
Both diameter and myelination critically increase __________ of action potential propagation
speed
_________ (thickest, myelinated)
Conduction speed: 80-120 m/s
A (alpha) Fibers
_________(thick, myelinated)
Conduction speed: 35-75 m/s
A (bravo) Fibers
_________ (thin, myelinated)
Conduction speed: 5-30 m/s
A (delta) Fibers
_________ (thinnest, unmyelinated)
Conduction speed: 0.5-2 m/s
C Fibers
Spinal Cord
a long, thin tubular
structure that comprises part of the
central nervous system
Spinal Nerve
a mixed nerve, which
carries motor, sensory, and autonomic
signals between the spinal cord and the
body
Doral Root
A bundle of axons
that enters a segment of the spinal
cord dorsally and consists mainly of
sensory axons
Ventral Root
A bundle of axons
that exits a segment of the spinal
cord ventrally and consists mainly of
motor axons
Dorsal root ganglion
A
small swelling in each dorsal
root that contains the cell
bodies of sensory neurons
(afferent)
Cell bodies in the dorsal root
ganglia do not have dendrites
and give rise to just ________
one axon
pseudounipolar
Neuron with a single process emerging from the
cell body, which splits into two major branches
99.8% of the cell’s
cytoplasm is in the _______
axon
Dorsal horn
a region at the back of the spinal column that
receives input from mechanoreceptors in the skin
_______________ fiber tract
ascends to the caudal medulla and
terminates in the Dorsal column
nuclei (DCN)
Dorsal column
One branch terminates in the
___________ of the grey matter,
close to where the fibers enters
the spinal cord
dorsal horn
Trigeminal nerve
The fifth cranial
nerve (nV) that contains somatosensory
axons coming from the face
Aβ fibers in the trigeminal nerve project
to the _________________ of the
trigeminal nerve, which is located in the
caudal pons (hindbrain)
principle nucleus
Somatotopic Organization
Organized in such a way that adjacent
parts of the body (usually the skin) are represented at adjacent
locations in the brain
Ascending projections are ______________ organized
Topographically
Primary somatosensory cortex (S1)
A
thin strip of cortex that receives input
from the dorsal thalamus
Homunculus
a drawing of a “little man” that is a map-like
representation of regions of the body in the brain
Somatosensory homunculus
A drawing of a “little man”,
showing the degree to which a part of the body is over- or
underrepresented in the somatosensory cortex
The overrepresented
regions (e.g. _______&
_________) are areas of
high touch acuity
hands; face
Barrel Cortex
A part of the rodent’s primary somatosensory
cortex (S1) that represents the whiskers
Exact ____________ of position of whiskers
replica
Lateral inhibition
The process by which neighboring neurons inhibit
each other
Contact between an
object and our skin
activates S1 in a
___________ pattern
that reflects the objects
shape
spatial
Neuronal rewiring is very common after brain injury and tends to
help restore __________________
behavioral function
The degree to which the occipital cortex responds to somatosensory stimuli depends on the
________________ at which the person became blind
age
Loss of input from the hand causes extensive “______________” in
somatosensory cortex
Remapping
Phantom Limb
A pain felt in the region of the body that is no
longer there (eg, due to amputation) or is no longer innervated by
sensory axons (eg, due to spinal cord injury)
Somatosensory inputs from the
face are ____________ to the
cortical region used to process
info from the arm or leg lost
rerouted
Thermoreceptor
a sensory receptor that signals
information about changes in skin temperature
cold fibers
a sensory
nerve fiber that fires when
skin temp decreases
warmth fibers
a sensory
nerve fiber that fires when
skin temp increases
Actual temperature is encoded by comparing __________________ of
warmth and cold receptors and that of nociceptors.
relative contribution
Thermally-sensitive transient receptor potential (ThermoTRP) channels
temperature-sensitive ion channels found in sensory neurons
TRP channels are activated over a specific _________ of temperatures
range
Thermoreceptors fire when we make contact with an object that is
____________________ than our skin
warmer or colder
Nociception
The neural process of encoding and processing
noxious stimuli
Noxious stimuli
Damages or threatens to damage tissue
(mechanical, thermal, or chemical)
Nociceptor
Afferent neuron preferentially sensitive to noxious
stimuli
Nociceptors have ___________________ that respond to
various types of tissue damage or to stimuli that has the
potential to damage tissue
five nerve endings
Thermoreceptive and nociceptive axons enter at the __________ of the
spinal cord
dorsal horn
Substantia gelatinosa
a dorsal region of the dorsal horn of
the spinal cord, where nociceptive axons terminate
Spinothalamic tract
route from the spinal cord to the brain that
carries information about skin temperature & nociceptive signals
*Terminates in dorsal thalamus, midbrain and medulla
Conscious perception of painful stimuli occurs in the ______________
Cortex
somatosensory
Axons of the spinothalamic tract
will synapse with relay nuclei in the
hindbrain and midbrain and
converge in the ______________
nucleus of the dorsal thalamus
ventral posterior
Congenital insensitivity to pain (CIP)
a condition that
inhibits the ability to feel physical pain
Analgesia
decreasing pain sensation during conscious
experience
Exogenous opioids
chemical compounds related to opium and
are NOT produced by the organism’s own body (e.g. morphine, heroin)
Endogenous opioids
chemical compounds that are related to
opium and are produced by the organism’s own body (eg. endorphin)
_________ bind to G-protein coupled opioid receptors
Opiods
Neurons that express the activated opioid receptors become much less
excitable (______________)
hyperpolarized
Opioid receptors are located in many nociceptive axons that
terminate in the __________________
substantia gelatinosa