EXAM 3 Lec 14 Flashcards
signal formation
external to organism: light, temperature, small molecule
internal: formation in the signaling cell and used internally or exported
signal molecule transport
long distance
intermediate
cell-cell contact
signal interaction with cell
diffuse across plasma membrane
plasma membrane blocks internalization
perception
conformation change binds to cell surface receptor and internal receptor
no perception, no signal
first transduction
a conformational change converting the initial signal into an internally-generated signal
endocrine signaling
whole body communication
hormones
endocrine cells
specialized cells producing hormones (pancreas)
paracrine signaling
local communication
local mediators
paracrine cells
any cells producing local mediators
autocrine signaling
self signaling
hormones
circulate throughout the body
signal produced and secreted into the bloodstream
local mediators
abundance varies locally
signaling molecules diffuse through extracellular fluid
synaptic neuronal signaling
long distance but targeted
intracellular signaling by electrical depolarization
extracellular signaling by a neurotransmitter
contact dependent signaling
signal molecule confined to the signaling cell
interaction with adjacent cell