Exam 3 Final Flashcards
Nervous System: releases neurotransmitters
- Molecules: neurotransmitters released in response to nerve impulses that bind to receptors on target cells but act as local messengers
- Site of action: close to site of release (at synapse) and binds to receptors on postsynaptic membrane
- Types of target cells: muscle cells, gland cells, other neurons
- Time to onset of action: within milliseconds
- Duration of action: very fast (milliseconds)
Endocrine System: releases hormones
- Molecules: hormones delivered to tissues through body by blood
- Site of action: far from site of release and binds to receptors on or in target cells
- Types of target cells: all cells throughout body
- Time to onset of action: seconds, hours, or days
- Duration of action: longer (seconds to days) because hormones have to manipulate target cells = effects take longer
Gland
single cell or mass of epithelial cells that specialize in secretion
Endocrine glands
secretes hormones that enter the interstitial fluid and diffuses into the bloodstream
Exocrine glands
don’t usually secrete hormones but secretes other substances that enter ducts that empty to the surface of a covering such as skin surface or the lumen of the stomach
Unicellular glands + goblet cells
- single cells
- produces mucin (mucin +water ⇒ mucus that protects and lubricates internal body surfaces) and is an exocrine gland
Multicellular glands
many cells that form distinctive microscopic structures or macroscopic organ
Hormone action in lipid-soluble hormones
- Circulates around blood using transport proteins because they’re hydrophobic
- Lipid-soluble hormones diffuses into target cells and does not need to bind to receptors on cell membrane because it travels through hydrophobic part of cell membrane
- Binds to nucleus receptors that can alter gene expression that makes for a protein, thereby altering cell activity
Hormone action in water-soluble hormones
- Circulates around blood freely with no need for transport proteins
- Binds to receptors in target cells that’s attached to cell membrane protein that’s connected to change-inducing messenger
- bind to G protein-coupled receptors on target cells activating enzymes such as adenylyl cyclase and cAMP which ultimately phosphorylate existing proteins leading to their activation
Hypothalamus and pituitary gland
work together to control other endocrine glands and connected by infundibulum
What hormones do the hypothalamus and anterior pituitary gland’s anterior lobe secrete? (7)
- growth hormone (GH)
- thyroid-stimulating hormone (TSH)
- follicle-stimulating hormone (FSH)
- luteinizing hormone (LH)
- prolactin
- adrenocorticotropic hormone
- melanocyte-stimulating hormone
Growth hormone (GH)
secretes insulin-like growth factors (IGFs) = promotes growth of body tissue by acting directly on target cells to enhance lipolysis and decrease glucose uptake
Thyroid-stimulating hormone (TSH)
stimulates synthesis and secretion of thyroid hormones by thyroid gland
Follicle-stimulating hormone (FSH)
- Females: starts development of oocytes and induces ovarian secretion of estrogen
- Male: stimulates testes to produce sperm
Luteinizing hormone (LH)
- Females: stimulates secretion of estrogens and progesterone (builds wall of uterus), ovulation, and formation of corpus luteum (yellow body)
- Males: stimulates testes to produce testosterone (primary sex hormone)
Prolactin
promotes milk production by mammary glands
Adrenocorticotropic hormone
stimulates secretion of glucocorticoids (mainly cortisol) by adrenal cortex
Melanocyte-stimulating hormone
produces pigmentation of skin when activated by UV light, suppresses appetite, and contributes to sexual arousal
What hormones does the hypothalamus and pituitary gland’s posterior lobe secrete? (2)
- Antidiuretic hormone
- Oxytocin
Antidiuretic hormone
Increases facultative reabsorption of water, which decreases osmolarity of body fluids
Oxytocin
- Mother’s uterus: enhances contractions
- Mother’s breasts: stimulates milk ejection by mammary glands in response to suckling
- released in response to stretch on cervix during childbirth
What cells make up the thyroid gland and their corresponding hormones? (2)
- follicular cells: Triiodothyronine and thyroxine hormones / thyroid hormones
- parafollicular cells: calcitonin
Follicular cells
stimulated by TSH to produce thyroxine and triiodothyronine (thyroid hormones)
Triiodothyronine and thyroxine (thyroid hormones)
- Help maintain normal body temp
- increase basal metabolic rate
- stimulate synthesis of proteins
- increase ATP production
- accelerate body growth
- contribute to development of nervous system
Parafollicular cells
produces hormone calcitonin to help regulate calcium homeostasis
Calcitonin
lowers blood lvls of Ca2+ and HPO42+ by inhibiting bone resorption by osteoclasts vs. accelerating uptake of calcium and phosphates into bone extracellular matrix
What two cells make up the parathyroid gland?
- chief cells
- oxyphil cells
Chief cells
produce parathyroid hormone (PTH) that’s released when calcium lvls are low ⇒ increases Ca2+ reabsorption by kidneys, promotes calcitriol formation, increases bone resorption
parathyroid hormone (PTH)
increases Ca2+ reabsorption by kidneys ⇒ promotes calcitriol formation ⇒ increases bone resorption
Oxyphil cells
secretes excess PTH in cases of parathyroid cancer
The adrenal gland is divided into 2 regions, what are they?
- inner medulla
- outer cortex
The outer cortex of the adrenal gland is divided into 4 regions, what are they from superficial to deep and what do they each secrete?
- Zona glomerulosa: mineralocorticoids
- Zona fasciculata: Glucocorticoids
- Zona reticularis: Androgens
- Adrenal medulla: Epinephrine / Norepinephrine
Mineralocorticoids
- increases blood lvls of Na+ and water
- decrease blood lvl of K+
Glucocorticoids
- upregulate expression of anti-inflammatory proteins
- regulates blood glucose lvls by stimulating gluconeogenesis and lipolysis
Androgens
- helps in early growth of axillary and pubic hair in both sexes
- Females: contribute to libido and source of estrogens after menopause
Epinephrine / Norepinephrine
increases heart rate and blood flow to muscles ⇒ increase breathing rate ⇒ bronchodilation
What does the pineal gland secrete? What does that do?
Melatonin: regulate body’s biological clock
What does the thymus produce and what do they do?
- produces thymosin, thymic humoral factor, thymic factor, and thymopoietin
- all promote maturation of immune system’s T cells
What are the pancreatic islet hormones and what are they secreted by? (4)
- glucagon: secreted by alpha cells
- insulin: secreted by beta cells
- somatostatin: secreted by delta cells
- pancreatic polypeptide: secreted by F cells
Glucagon: secreted from alpha cells
raises blood glucose lvl by accelerating glycogenolysis and gluconeogenesis
Insulin: secreted from beta cells
lowers blood glucose lvl by accelerating glycogenesis ⇒ increasing lipogenesis and stimulating protein synthesis
Somatostatin: secreted from delta cells
inhibits secretion of insulin and glucagon ⇒ slows absorption of nutrients from GI tract
Pancreatic polypeptide: secreted from F cells
inhibits somatostatin secretion, gallbladder contraction, and secretion of digestive enzymes
What is the impact of insulin/glucagon on blood glucose lvls (controlled by negative feedback)? What are the three conditions you can get?
- hyperglycemia (chronic high blood glucose)
- Type 1 Diabetes mellitus
- Type 2 Diabetes mellitus
hyperglycemia (chronic high blood glucose)
- due to improper insulin secretion or insulin insensitivity
- Insufficient release of insulin and/or insulin resistance ⇒ increased glucagon release ⇒ increasing blood glucose lvls
Type 1 Diabetes Mellitus
autoimmune disease characterized by destruction of beta cells ⇒ little or no insulin secretion
Type 2 Diabetes Mellitus
hyperglycemia due to insulin resistance; target cells don’t respond to insulin normally
What are the growth factors? (5)
- epidermal growth factor (EGF)
- platelet-derived growth factor (PDGF)
- fibroblast growth factor (FGF)
- nerve growth factor (NGF)
- tumor angiogenesis factors (TAFs)
Epidermal growth factor (EGF): Secreted by salivary glands
- Stimulates proliferation of epithelial cells, neurons, neuroglia
- Suppresses cancer cells
- Secretion of gastric juice by stomach
Platelet-derived growth factor (PDGF): produced in blood platelets
- stimulates proliferation of neuroglia, smooth muscle fibers, and fibroblasts
- helps with wound healing
Fibroblast growth factor (FGF): found in pituitary gland and brain
- stimulates proliferation of smooth muscle fibers, chondrocytes, endothelial cells
- stimulates formation of new blood vessels (angiogenesis)
Nerve growth factor (NGF): produced in salivary glands and hippocampus of brain
- Stimulates growth of ganglia in embryo
- Maintains sympathetic nervous system
- Stimulates hypertrophy
- Stimulates neuron differentiation
Tumor angiogenesis factors (TAFs): produced by tumor cells
- stimulates growth of new capillaries/blood vessels, organ regeneration, and wound healing