Exam 3 - Complicated Diabetic Patients Flashcards

1
Q

what are some long term potential complications that need to be managed for diabetic patients?

A

DKA - both dogs & cats

UTIs - both dogs & cats

cataracts - dogs

peripheral neuropathy - cats

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2
Q

what defines a complicated/problematic diabetic patient?

A

uncontrolled clinical signs related to hyperglycemia - excessive thirst, urination, & hunger

episodes of hypoglycemia - sleepiness, confusion, blindness, & seizures

maintain a suitable body weight - weight loss despite treatment

long term complications aren’t managed - DKA, UTIs, cataracts, & peripheral neuropathy

patient is not meeting these goals

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3
Q

what is the most important goal of managing diabetic patients?

A

a happy owner is most important!!! patient’s life line

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4
Q

what 4 questions do you need to answer when approaching a complicated diabetic patient?

A
  1. did the insulin have ANY effect?
  2. nadir (lowest BG value)
  3. duration of the EFFECT of insulin
  4. average BG concentration
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5
Q

what are the main 3 reasons we have for why diabetic patients become complicated?

A
  1. insulin related
  2. client related
  3. patient related - very complicated diabetic patient!!!
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6
Q

what kind of patient presentation for a diabetic animal would make you think that there is an insulin-related problem?

A

previously well controlled diabetic patient becomes suddenly unregulated!!!!

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7
Q

what are 3 reasons for how insulin can lose its effect?

A
  1. agitation - bottle should be ROLLED gently (vetsulin should be shaken)
  2. exposure to heat or extreme cold
  3. bacterial contamination - ALWAYS store in the fridge & follow the manufacturer’s instructions regarding shelf life
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8
Q

T/F: always discard a suspected bottle if a previously stable diabetic deregulates

A

true

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9
Q

what kind of patient presentation for a diabetic animal would make you think that there is an client-related problem?

A

newly diagnosed diabetic!!!

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10
Q

what are some ways in which a client may be making a mistake when giving their pet insulin? how can these mistakes be counteracted?

A

owner fails to expel air bubbles/owner draws the apparatus back while injecting

owner can’t see the markings on the syringe - need to use the smallest possible syringe, use an insulin syringe magnifier, switch to an insulin pen (more accurate especially at lower doses, easier to use, but more expensive)

owner may be injecting the insulin into the pet’s hair, intradermally, or ‘through and through’ - shave patches of hair so that they can see the needle, use an > 11 mm needle because ultra-comfort needles are too short

mismatch between U/ml of insulin & syringe

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11
Q

what is so very bad about U/ml & insulin syringe mismatch?

A

U40 insulin with a U100 syringe - SUBSTANTIAL UNDER DOSE

U100 insulin with U40 syringe - results in 2.5X overdose

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12
Q

how can you figure out if a complicated diabetic patient is having issues due to client-related issues?

A

watch the owner draw up insulin & give a test dose of saline to identify if the client is the issue

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13
Q

T/F: before considering patient-related issues, you need to consider insulin & client-related issues first as these are easier to identify & fix

A

true

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14
Q

what do you need to look at for patient-related problems in complicated diabetics?

A

BG data!!!!!!!!!

need to know if insulin has any effect, nadir, average BG, & duration of effect

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15
Q

what are the 3 categories that patient related problems are divided into for complicated diabetics?

A
  1. episodes of hypoglycemia
  2. short or unpredictable duration of effect of the insulin
  3. insulin resistance
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16
Q

what does the somogyi overswing effect look like? when do we commonly see it?

A

looks like insulin resistance, but in fact, the patient is OVERDOSED!!!!!!!!!

happens when insulin is increased based on spot checks of BG

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17
Q

what are some reasons that we may see episodes of hypoglycemia in a diabetic animal with patient-related problems?

A

current insulin dose is too high

cat or post-diestrus female dog is going into diabetic remission

irregular exercise program - unaccustomed exertion will cause problems so clients need to keep pets on a regular schedule (20 minute walk after meals ideal for dogs)

consider other hypoglycemic disorders - addison’s, insulinomas, large liver tumors, & beta blocker administration

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18
Q

what are some reasons that we may see short or unpredictable duration of insulin effect in a diabetic animal with patient-related problems?

A

insulin isn’t a good choice for the patient - lente in a cat or PZI for a dog

insulin is erratically absorbed from SQ space - repeated use of the same site can cause problems

intestinal disease - may impact nutrient absorption (secretion of key gi hormones, incretins, may be impacted & alter glucose homeostasis & response to food intake)

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19
Q

how does repeated use of the same injection site for insulin potentially cause problems for diabetic patients? how is this fixed?

A

the animal can get an inflammatory reaction at the injection site

have the owner rotate sites to avoid causing this problem

20
Q

what defines insulin resistance in diabetic dogs & cats?

A

dogs - BG stays > 300 mg/dl despite getting 1.5 U/kg dose

cats - BG stays > 300 mg/dl despite 5 U/kg

21
Q

what is the somogyi overswing?

A

acute hypoglycemia (insulin dose too high) triggers counter-regulatory hormones that can cause a persistent hyperglycemia for up to 24 hours

22
Q

what are the categories that we use for classifying insulin resistance?

A
  1. infection
  2. inflammation
  3. concurrent endocrinopathies/metabolic disorders
  4. medications
  5. anti-insulin antibodies
23
Q

what are some examples of infections that can lead to insulin resistance in diabetic patients?

A

oral cavity - dental issues can cause substantial insulin resistance, so you need to address a bad mouth early

UTI - urine sediment exam may miss an infection due to DM

pneumonia

24
Q

what are some examples of inflammatory conditions that can lead to insulin resistance in diabetic patients?

A

pancreatitis - can wax/wane, diagnose with PLI or ultrasound

stomatitis

IBD

OA

25
Q

how can hypothyroidism cause insulin resistance in a diabetic dog?

A

patient gains weight despite poor diabetic control - uncontrolled DM will affect testing & will drive down total T4

26
Q

how can hyperadrenocorticism cause insulin resistance in a diabetic dog?

A

signs of HAC overlap with poorly regulated DM - uncontrolled DM will affect testing & be a difficult diagnosis to make

27
Q

how can acromegaly cause insulin resistance in a diabetic dog?

A

seen in diestrus females - progesterone triggers the release of GH from mammary tissue & antagonizes the effects of insulin

28
Q

how can hyperthyroidism cause insulin resistance in a diabetic cat?

A

uncontrolled DM will drive down total T4 - measure free T4 in equivocal cases

29
Q

when would you consider acromegaly as the cause of insulin resistance in a diabetic cat?

A

consider this if the cat gains weight despite poor diabetic control! these cats need huge insulin doses

usually male cats

30
Q

how is acromegaly diagnosed in a diabetic cat? what is required to be done prior to testing?

A

measure IGF-1

patient needs to be on insulin for 6 weeks before measuring!!!!

31
Q

how can hyperadrenocorticism cause insulin resistance in a diabetic cat?

A

uncommon but strongly associated with DM - use a LDDST to make this diagnosis

32
Q

how can obesity cause insulin resistance in a diabetic dogs & cats?

A

adipokines impact insulin responsiveness

33
Q

what concurrent medications may cause insulin resistance in diabetic patients?

A

glucocorticoids (topical & systemic) & synthetic progestins (megestrol acetate)

34
Q

what is the theoretical issue of anti-insulin antibodies causing insulin resistance in diabetic patients?

A

antibodies bind insulin at the injection site & then affect its release

theoretical issue - very little data to suggest it’s an actual issue

35
Q

what are the 10 steps to working up an insulin resistance diabetic dog?

A
  1. review history & physical exam
  2. thorough review of concurrent medications
  3. check sexual status, do an OHE if intact female
  4. routine cbc, chem, UA
  5. urine culture
  6. thyroid panel - especially if patient is gaining weight
  7. consider cushings - shave hair & re-evaluate growth, LDDST/ACTH stim
  8. consider spec cPLi particularly if appetite is variable
  9. consider dental cleaning if oral exam is supportive
  10. more extensive search for occult systemic disease (serum folate/cobalamin, thoracic radiographs, & abdominal ultrasound)
36
Q

what are the 11 steps to working up an insulin resistance diabetic cat?

A
  1. review history & physical exam
  2. thorough review of concurrent medications
  3. routine cbc, chem, UA - measure free T4 if total T4 is at the upper end of normal
  4. urine culture
  5. consider spec fPLi particularly if appetite is variable
  6. consider serum cobalamin measurement particularly if appetite is variable
  7. consider running fTLi - if stools are soft
  8. consider dental cleaning if oral exam is supportive
  9. consider acromegaly - particularly if cat is gaining weight & measure IGF-1
  10. consider hyperadrenocorticism - particularly if skin changes are noted, run LDDST
  11. more extensive search for occult systemic disease (thoracic radiographs & abdominal ultrasound)
37
Q

what is the best option for glucose measurements in complicated diabetic patients?

A

best done at home for cats

hand held glucometer or interstitial glucometer

serum fructosamine concentrations

38
Q

what is the target nadir for diabetic patients? how often should you take blood glucose readings on cats managed with glargine?

A

target 100-150 mg/dl

every 3-4 hours

39
Q

what are some common causes of the somogyi response?

A

spot check done at anticipated nadir

BG checks are > 2 hours apart

connecting the dots on a curve & not spotting a gap

40
Q

how long do we aim for insulin to last in dogs?

A

aim for 10-12 hours

41
Q

what is the average blood glucose level we aim for in diabetic patients?

A

<250 mg/dl

42
Q

when does diabetic remission often occur in cats?

A

usually occurs within the first 3 months

43
Q

how do you address inappropriate insulin metabolism in complicated diabetic patients?

A

inappropriate insulin metabolism - change the insulin type

44
Q

for a diabetic dog, what insulins may you choose & why?

A

BID intermediate insulins are a good choice - lente, NPH/isophane, detemir - dogs have substantial post-prandial hyperglycemia!!!

avoid PZI - unpredictable kinetics & variable absorption

45
Q

for a diabetic cat, what insulins may you choose & why? why not lente?

A

glargine & PZI - need a long acting insulin because cats have a very long post prandial phase because they are designed to snack & not meal feed

lente insulins are too short acting & the fast acting portion can drive down BG

46
Q

how would you verify hypothyroidism in a diabetic dog? what would you expect to see?

A

thyroid panel

free T4 - should be low
TSH - should be high
TSH stimulation test - flat line