Exam 3: Autoimmune diseases

Question 1

Effects of Gold compounds to treat autoimmune diseases

Answer 1

Decrease inflammation

Slows progression of bone and articular destruction

Question 2

T or F, gold compounds are expensive to buy and administer

Answer 2

True

Question 3

Name the Gold compound drugs used to treat RA

Answer 3

• aurothioglucose
• auranofin (Ridaura)
• gold sodium thiomalate (Aurolate)

Question 4

T or F, There is a low incidence of toxicity in gold compounds

Answer 4

False, High incidence = requires intensive monitoring
Symptoms 
- Dermatitis with mucosal ulcerations
- Proteinuria
- Neutropenia
- Thrombocytopenia

Question 5

List the oral complications with Gold

Answer 5

Infection 
Delayed healing
Prolonged bleeding
Glossitis
Aphthous stomatitis
Blue-black intramural pigmentation

Question 6

Indications for Immunosuppressive drugs

Answer 6

Used in cases of refractory RA

Question 7

List the immunosuppressive drugs

Answer 7

azathioprine (Imuran, Azasan)
cyclophosphamide (Cytoxan)
cyclosporine (Sandimmune, Gengraf, Neoral, Restasis)

Question 8

What immunosuppressant is used in dentistry with prednisone for major oral mucosal problems?

Answer 8

azathioprine
- used for severe erosive lichen plans, major aphthous stomatitis, erythema multiforme, benign mucous membrane pemphigoid

Question 9

cyclophosphamide (Cytoxan) is a part of what two drug classes?

Answer 9

Immunosuppressant

Antineoplastic drug

Question 10

Indication for cyclophosphamide (Cytoxan)

Answer 10

Used for severe RA

Question 11

Side effects of Cytoxan

Answer 11

alopecia
infertility
GI
blood dyscrasias

Question 12

Indication for cyclosporine

Answer 12

• Used primarily to prevent rejection of organ transplants

- Used for severe active RA that is not responsive to methotrexate

Question 13

When is cyclosporine contraindicated

Answer 13

For RA if have abnormal renal function, uncontrolled hypertension, malignancies

Question 14

3 uses for synthetic glucocorticoid medications

Answer 14

1. Autoimmune diseases
2. Immunosuppressive therapy in organ transplant patients
3. Respiratory disease management

Question 15

List the salivary stimulating medications

Answer 15

pilocarpine (Salagen)

cevimeline (Evoxac)

Question 16

Elevated BP in autoimmune patients may be due to what?

Answer 16

Chronic pain

Question 17

Do autoimmune patients require Antibiotic premedication?

Answer 17

Most DO NOT require antibiotic premedication

ADA task force recommendations for patients with prosthetic joints