Exam 3 Flashcards
Epidermis
Keratinized stratified squamous epithelium
Dermis
Dense irregular tissue
Keratinized
Change or become changed into a form containing keratin.
Keratinized
Protects deep tissue from abrasion, found on the sole of the foot and palms of hand.
Non-keratinized
Must be kept moist from bodily secretions to to prevent drying out, found in the lining of the oral cavity, pharynx, esophagus, lining of vagina and anus.
5 Layer of Epidermis/ deep to superficial
Stratum Basale, Stratum Spinosum, Stratum Granulosum, Stratum Lucidum (thick only), Stratum Corneum
Stratum Basale/Stratum Germinative/Basal Layer
Deepest layer, single layer of cuboidal to lower columnar cells tightly attached to an underlying basement membrane that separates the epidermis from the connective tissue or adjacent dermis.
Stratum Basale/Stratum Germinativum/Basal Layer Cells
Keratinocytes: dead, divide to generate new cells.
Melanocytes: Alive, produce and store pigment melanin.
Tactile cells/Merkel Cells: Alive, sensitive to touch, when compressed release chemicals that stimulate sensory nerve endings providing info about objects touching skin.
Stratum Spinosum/Spiny Layer
Made up of several layers of polygonal keratinocytes. Each time a keratinocyte stem cell divides, a daughter cell is pushed to the external surface of the Stratum Basale. Once it enters the Stratum Spinosum, it begins to differentiate into non-dividing, highly specialized keratinocyte.
Stratum Spinosum/Spiny Layer Cells
Epidermal Dendritic Cells: Alive, immune cells that help fight infection.
Stratum Granulosum/Granular Layer
Consists of 3-5 layers of keratinocytes superficial to the Stratum Spinosum. Process of Keratinization begins here.
Stratum Granulosum/Granular Layer Cells
Keratinized Cells: Dead, because there is no nucleus or organelles but are structurally strong because of the keratin it contains.
Stratum Lucidum/Clear Layer
Thick skin only, is a thin translucent region of dead skin cells about 2-3 cell layers that is superficial to the Stratum Granulosum. Located on the palms of hands and soles of feet.
Stratum Lucidum/Clear Layer Cells
Keratinocytes that are flattened and filled with translucent protein called eledin. This layer helps protect from UV light.
Stratum Corneum/Hornlike Layer
Is the most superficial layer of the epidermis. Is the Stratum you see when you look at your skin.
Stratum Corneum/Hornlike Layer Cells
20-30 layers of dead, Anucleate cells that are scaly, interlocking keratinized Cells. Functions as a barrier.
Where does keratinization begin?
In the Stratum Granulosum
What are the differences in thick and thin skin?
Thick skin has stratum Lucidum, thin skin does not.
Thick skin
Found on palms of hands and soles of feet and has no hair follicles or oil glands.
Thin Skin
Covers most of the body, and has hair follicles and oil glands.
What combination helps give skin color and tone?
Hemoglobin, melanin, carotene
Albinism
Inherited recessive condition where enzyme needed to produce melanin is non-functional. Individuals have White hair, pale skin, and pink irisis.
Nevus
Commonly called a mole, is a harmless overgrowth of melanocytes.
Freckle
Yellowish or brown spots that represent localized areas of increased melanocyte activity. Degree of pigmentation depends on sun exposure and hereditary.
Hemangioma
An anomaly that results in skin discoloration due to blood vessels that proliferate to form a benign tumor.
Friction Ridge
Type of skin marking, found on contours of skin such as fingertips, palms, soles and toes. Increase friction and allow for identification of individuals since they are unique to each person.
Cleavage Lines
Tension lines in the skin that identify predominant orientation of colleges fiber bundles. These lines are taken into consideration during surgery.
What are the two layers of the Dermis?
Papillary Layer and Reticular Layer
Papillary Layer
Superficial layer of the dermis, composed of areolar connective tissue
Reticular Layer
Deepest layer of Dermis, composed of dense irregular tissue
Why are tattoos permanent?
Dye is injected into the dermis which does not have rapid cell turnover, which means the dye will remain in the area for a long time.
Hypodermis
Subcutaneous Layer/superficial Fascia. Not considered part of the integument. Has both areolar and adipose connective tissue.
Vasoconstriction
Diameters of the vessels narrow, so less blood can travel through them.
Vasodilation
Diameter of the vessels increases, so more blood can travel through them.
Integumentary system structures derived from epidermis
Nails, hair, and exocrine glands of the skin.
Yellow Nail Syndrome
Occurs when growth and thickening of nails slows or stops entirely. Outward sign of respiratory disease or chronic bronchitis
Spoon Nails
Nail malformation where the outer surface of the nails are concave instead of convex. Frequently a sign of iron deficiency.
Beau’s Lines
Run horizontally across the nail and indicate a temporary interference with nail growth at the time the nail was formed. Sign of chronic malnutrition.
Two types of Exocrine Glands
Sweat Glands and Sebaceous Glands
Merocrine Glands
Secretes Sweat/ cools the body down/ most widely distributed cells
Apocrine Glands
Secrete fat droplets into breast milk and fat droplets into the ear to produce ear wax.
Ceruminous Glands
Modified apocrine sweat glands only in the ear canal, where they secrete a waterproof ear wax called cerumen.
Mammary Glands
Of the breasts are modified apocrine sweat glands. Both male and female have them. Only become functional in pregnant/lactating females and produce milk to feed offspring.
Difference between Merocrine, Apocrine, and Holocrine glands?
Merocrine secretion does not damage the cell. Aprocrine: part of the cell breaks off and is released. Holocrine Secretion: destroys the whole cell.
Regeneration
The replacement of damaged or dead cells with the same cell type.
Fibrosis
The process of scar tissue deposition during healing, serves to bind damaged parts together.
Psoriasis
Chronic autoimmune skin disease that has periods of flare-ups and remissions. The normal sloughing-off cycle of keratinocytes is thrown out of balance and the cells develop into patches of white scaly skin
Greatest risk factor for skin cancer?
Chronic exposure to UV rays and fair-skinned individuals, especially those who had sever sunburns and children.
Cyanosis
Bluish discoloration of the skin resulting from poor circulation or inadequate oxygenation of the blood.
Bruise
Blood or bleeding under the skin due to trauma; typically black and blue at first, with color changes as healing progresses.
Jaundice
Yellowing of the skin and eyes that occurs when the liver’s ability to eliminate bilirubin is impaired.
Mechanoreceptor
Responds to distortion of the plasma membrane that occurs due to touch, pressure, vibration and stretch.
Encapsulated sensory receptor
Has a special capsule which enclosed a nerve ending.
Unencapsulated sensory receptor
No special structure and are basically free nerve endings. (Pain/temperature receptors)
Free Nerve Endings
Tactile receptors, either tonic receptors (adapt slowly) or phasic receptors (adapt quickly).
Where do free nerve cells reside and what do they detect?
Closest to the surface of the skin in the papillary Layer and detect temperature and pain stimuli and also detect light touch and pressure.
Root Hair Plexuses
Specialized terminal endings of sensory neurons that form a weblike sheath around hair follicles in their reticular layer of the dermis.
What do root hair plexuses detect?
Movement. Sends and receives nerve impulses to the brain when the hair moves.
Where are Merkel cells located and what do they detect?
Stratum Basale, light touch sensation
Where are End/Krause bulbs located?
Ensheathed in connective tissue found in the dermis of the skin, mucous membranes of the oral cavity, vagina and anal canal.