Exam 3 Flashcards
the body’s largest organ in terms of surface area and weight.
The skin
Skin would cover
1.5 to 2.0 square meters if surface area if flattened into a sheet
Skin makes up approximately ____ of your total body weight
15%
Organization of the skin
consists of a superficial epidermis and a deeper dermis; below this is the hypodermis, which is a layer of connective tissue.
thickness of skin
1mm to 2mm thick; ranges from 0.6 mm in eyelids to 6.0 mm on back
thick skin
has five epidermal layers and covers the palms, soles, fingers, and toes with a surface layer of dead cells and it lacks hair follicles
thin skin
has four thinner epidermal layers and covers all other parts of the body
Dermatology
the study and treatment of the integument and the appearance and/or condition of one’s skin can provide diagnostic information regarding one’s overall health.
organization of the epidermis
consists of keratinized stratified squamous epithelium that is organized into several distinct strata.
blood supply of epidermis
it contains no blood vessels, so its cells depend on diffusion of oxygen and nutrients from blood vessels in underlying connective tissue
The stratum basale
consists of a single layer of cuboidal or columnar cells that continuously undergo mitotic cell division to produce new skin cells.
keratinocytes
the most abundant cells and are held together by desmosomes
helps to waterproof skin
Tough, fibrous keratin protects skin from heat, microbes, chemicals
melanocytes
synthesize the pigment melanin
melanin
responsible for skin color and it absorbs ultraviolet radiation to protect skin from damaging effects of sunlight
Merkel cells
touch receptors that join with sensory neurons to form Merkel discs
The stratum spinosum
consists of several layers of keratinocytes.
when skin is prepared for microscope slides,
keratinocytes shrink and pull apart, except where attached by desmosomes
dendritic (Langerhans) cells
macrophages that a rise in bone marrow and migrate to the epidermis to protect body against microbes that invade skin
The stratum granulosum
consists of keratinocytes that contain dark-staining granules of protein that eventually become keratin.
as keratinocytes flatten,
the nucleus and organelles disintegrate and granules of keratin accumulate in the cytoplasm
the outer limit for diffusion of substances
the stratum granulosum
The stratum lucidum
a thin, translucent layer of dead cells found only in thick skin.
The stratum corneum
contains up to 30 layers of dead, scaly keratinized cells and makes up about 75% of the thickness of the epidermis.
it takes ________________ for a keratinocyte to migrate to the skin’s surface and exfoliate
30 to 40 days
most household dust is made up of
dander
the presence of dander in bedding provides food for
dust mites
an allergy to household dust is actually an allergy
to the feces of dust mites
persistent friction with the stratum corneum layer can cause
a thickened callus to form
organization of the dermis
consists of connective tissue comprised mainly of collagen fibers, but elastic fibers, reticular fibers, fibroblasts, and macrophages are also present.
dermal papillae.
The boundary between the dermis and the epidermis
these finger-like projections of the dermis extend into the epidermis to form epidermal ridges on the palms, fingers, soles, and toes; they increase grip by increasing friction
dermal papillae.
The papillary layer
a superficial zone comprised of areolar connective tissue that contains elastic fibers.
The papillary layer contains
capillaries, touch receptors (Meissner’s corpuscles), and numerous free nerve endings
The reticular layer
a deep zone comprised of dense irregular connective tissue that contains collagen bundles.
The reticular layer contains
adipocytes, hair follicles, nerves, oil glands, and the ducts of sweat glands
provide the skin with strength, extensibility, and elasticity
collagen fibers and elastic fibers
stretch marks
Small tears may occur during pregnancy or as result of obesity; produce silvery white stretch marks on thighs, buttocks, abdomen, breasts
subcutaneous hypodermis or superficial fascia
Beneath the dermis
the subcutaneous hypodermis consists of
areolar connective tissue and adipose tissue
functions of the subcutaneous hypodermis
binds skin to underlying tissue, cushions body, provides thermal insulation, stores energy
blood supply of the subcutaneous hypodermis
numerous blood vessels supply the skin with oxygen and nutrients and provide pathway for rapid absorption of drugs and/or medicines into bloodstream
Pacinian corpuscles
nerve endings in the subcutaneous hypodermis that are sensitive to pressure
Skin color is determined by
genes that control the interaction of melanin, carotene, and hemoglobin.
Melanin produces
variations in skin color that range from pale yellow to black.
exposure to ultraviolet radiation in sunlight
stimulates melanocytes to increase their production melanin so skin becomes darker
differences in skin color
due primarily to differences in amount of melanin produced (all races have approximately the same number of melanocytes)
melanin tends to be most plentiful in
face, limbs, around nipples, and external genitalia
in people with dark skin,
melanin breaks down slowly making it visible in all epidermal layers
in people with light skin
melanin breaks down rapidly making it less visible beyond stratum basale
freckles
flat patches of skin where melanin accumulates
moles
elevated patches of skin where melanin accumulates
vitiligo
results from partial or complete loss of melanocytes in patches of skin and produces irregular white blotches
Carotene
a yellow-orange pigment that accumulates in the stratum corneum or sub-cutaneous fat, which gives the skin a yellowish tint.
If there are small amounts of melanin and carotene
the epidermis becomes translucent.
hemoglobin molecules in the blood
become visible, which produces the pinkish flesh tones that are typical of Caucasian skin
Erythema
describes abnormal redness due to the dilation of dermal blood vessels during strenuous exercise or heat or anger or embarrassment.
Cyanosis
describes blueness of the skin due to insufficient oxygen in the blood because of airway obstructions or lung disease or cold weather.
Jaundice
a yellowing of the skin and the whites of the eyes due to elevated levels of bilirubin in the blood because the liver is unable to dispose of the excess bilirubin.
Pallor
describes pale skin due to reduced dermal blood flow because of low blood pressure or shock or anemia or emotional stress.
Albinism
a genetic defect that results in a lack of the amino acid tyrosine, which blocks the synthesis of melanin and produces pale skin, white hair, and pink eyes.
hematoma
a visible blood clot caused by trauma to the skin, which produces a bruise.
hemangiomas
“birthmarks” caused by benign tumors of dermal blood vessels
Hair (pili) covers
all skin surfaces except for the palms, soles, eyelids, lips, and nipples.
probably vestigial and has no essential function,
human hair
scalp hair
reduces heat loss and provides protection from ultraviolet radiation
eyebrows
enhance facial expression and non-verbal communication
eyelashes
shield the eyes from rain and windblown debris
guard hairs
prevent foreign particles from entering the nostrils or ear canals
Each hair consists of
columns of dead, keratinized cells that are fused together.
hair shaft
portion of a hair above the skin surface
hair root
deep to the shaft and is surrounded by a tube called the follicle
hair bulb
a swelling at the base of the follicle from which a hair originates
papilla
contains blood vessels to nourish hair
Each hair has _____ layers
three
inner medulla
contains air spaces
cortex
consists of densely packed keratinized cells
cuticle
a single layer of overlapping scaly cells; as cuticles wear away, keratin fibrils spill out of cortex and medulla causing ‘split ends’ to develop
Hair texture is related to
the cross-sectional shape of the hairs and hair color is due to the type and amount of pigment in each hair.
if the hair shafts are flat and ribbon-like
the hair becomes “kinky”
if the hair shafts are oval
the hair becomes “silky/wavy”
if the hair shafts are round
the hair becomes “straight/coarse”
Gray and white hair
lack melanin in cortex and have air bubbles in shaft
Red hair
colored by iron-containing pigment
coarse, long hair of eyebrows and scalp is
terminal hair
terminal hair
grows in response to testosterone,so it appears in auxiliary and pubic regions when males and females go through puberty
Hair growth follows
a cycle.
stem cells from the follicle
multiply and push the papilla deeper into the skin
cells in the root sheath
transform into hair cells that synthesize keratin
as they push upward away from papilla
the hair dies
a hair goes into a
resting stage and will eventually fall out
Normal adult hair loss
50-100 hairs per day
scalp hairs grow about
1 mm every three days with an annual growth of 10 to 18 cm
alopecia
hair loss; hair growth slows down around age 40 and alopecia occurs because of aging or disease or poor nutrition or medical treatment
pattern baldness
genetic condition expressed in individuals with high testosterone
An arrector pili muscle
consists of smooth muscle and is associated with each hair.
cold temperatures, fright, or emotional stress
can cause these muscles to contract and pull a hair into a vertical position producing ‘goose bumps’
Nails
plates of hard, keratinized cells that form protective coverings over the dorsal surface of the terminal portion of the fingers and toes.
The visible portion of a nail is the
nail body
the hidden portion of a nail is the
nail root
portion of the nail that extends beyond the end of the digit is the
free edge
a small white area at the proximal end of the nail body
lunule
dead epidermis that covers the proximal end of the nail
cuticle
Nail growth occurs by
mitosis from the nail matrix at a rate of about 1 mm per week.
Sebaceous (oil) glands
usually connected to hair follicles, although some of them open directly to the surface of the skin.
keep hair from drying out and turning brittle, to keep skin soft and moist, to inhibit growth of certain bacteria
an oily sebum secreted by oil glands
accumulation of sebum in facial sebaceous glands
causes blackheads which can lead to formation of pimples if they become infected with bacteria
Ceruminous glands
modified sweat glands in the outer ear canal that produce a waxy secretion called cerumen to provide a sticky barrier against the entrance of foreign bodies.
Sudoriferous (sweat) glands
produce a mixture of water, salts, and organic compounds.
sweat
regulates body temperature by providing a cooling mechanism; it also eliminates urea, lactic acid, ammonia, and some drugs from the body
between 3 and 4 million eccrine sweat glands
distributed throughout the skin, especially in palms, soles, forehead; they produce watery perspiration
apocrine sweat glands
located in armpits, pubic area, breasts, and beard area of mature males where their ducts lead to nearby hair follicles rather than to the surface of the skin
apocrine glands produce a viscous perspiration
contains organic substances that can be source of body odor
development of apocrine glands
do not develop until puberty and respond to emotional stress or sexual arousal
apocrine glands in females
these glands enlarge and shrink during the monthly menstrual cycle
Skin
provides a protective physical barrier against abrasion.
anti-bacterial substances
bacteria have trouble multiplying because of anti-bacterial substances that are present in sebum and sweat
Bacteria that invade skin are attacked by
macrophages and leukocytes
keratin
waterproof nature of keratin prevents dehydration and absorption of excess water
melanin
provides some protection against damage from ultraviolet radiation
Transdermal absorption
the ability to absorb drugs and/or chemicals across the epidermis.
nitroglycerine
can be absorbed to relieve heart pain
scopolamine
can be absorbed to reduce motion sickness
nicotine patches
can be used to quit smoking
hormones
can be absorbed for purposes of birth control
toxins
from poison ivy, organic solvents, and metal salts can be easily absorbed
Exposure to ultraviolet light
helps the skin convert a form of cholesterol into vitamin D.
Vitamin D
aids in absorbing calcium and phosphorous from food
Perspiration
eliminates some organic wastes, salts, and water from the body.
Nerve endings
can detect stimuli that get interpreted as touch, pressure, temperature, or pain.
The regulation of body temperature by the skin and other organs is a great example of
homeostasis
Excessive heat
triggers thermoreceptors in the skin to send nerve signals to a temperature control region in the hypothalamus of the brain.
signals send to temp control regions
cause sweat glands to increase perspiration which cools body as sweat evaporates;dermal blood vessels dilate and blood flow increases so more heat can be released
Extreme cold
triggers thermoreceptors in the skin to send nerve signals to the temperature control region in the hypothalamus.
hypothalamus
sends signals to dermal blood vessels that reduce blood flow to conserve heat
involuntary contractions of skeletal muscles
cause shivering,which produces heat to compensate for loss if heat from body’s surface
Regeneration
replaces dead or damaged cells resulting from cuts, scrapes, and/or burns with the same cell type in order to restore normal function to the tissue
fibrosis
replaces damaged tissue with scar tissue that consists mainly of collagen fibers, so normal function gets altered
During an inflammatory phase
mast cells escape from damaged blood vessels and release histamine in order to increase blood flow to the site of the wound.
During a migratory phase
a blood clot forms and scabs over to temporarily seal the wound.
macrophages
enter the wound and phagocytize cellular debris
During a proliferative phase
new blood capillaries develop.
fibroblasts
deposit collagen fibers into the blood clot filling the wound with granulation tissue
During maturation phase
surface epithelial cells multiply and loosen scab until it eventually falls off.
the leading cause of skin cancer
Excessive exposure to sunlight; fair-skinned people and the elderly are most susceptible.
Basal cell carcinoma
the most common type of skin cancer, but the least dangerous.
Basal cell carcinoma tumors
arise from pre-cancerous cells in the stratum basale, but rarely metastasize
Squamous cell carcinoma
less common and will metastasize if neglected.
Squamous cell carcinoma tumors
arise from keratinocytes in the stratum spinosum of scalp, ears, or back of hand; often from pre-existing skin lesions on sun- damaged skin
Malignant melanoma
the least common, but metastasizes quickly and can be fatal.
most prevalent type of life-threatening cancer among young women
Malignant melanoma
Malignant melanoma tumors
often arise from malignant melanocytes in a pre-existing mole
successful treatment depends on early detection (malignant melanoma)
A - asymmetry of mole
B - irregular border of mole
C - uneven and multiple coloration
D - diameter greater than 1/4 inch
Risk factors for skin cancer:
individuals with fair skin who tend to burn rather than tan
excessive exposure to sun and frequent occurrences of severe sunburn
family history of skin cancer
individuals who have a suppressed immune system
Tissue damage to the integument
destroys the protection afforded by the skin because it permits microbial invasion, infection, fluid loss, and loss of thermoregulation.
First-degree burns
characterized by redness and pain in the surface epidermis.
first degree burn healing
takes a few days and may be accompanied by peeling or flaking
example of first degree burns
most sunburns
Second-degree burns
destroy the entire epidermis and at least parts of the dermis; characterized by redness, blister formation, fluid accumulation, and pain
second degree burn healing
takes several weeks and mild scarring may occur
Third-degree burns
destroy the epidermis, dermis, and even parts of the hypodermis;
third degree burn pain
loss of sensory nerve endings actually limit pain
Third-degree burns excessive fluid loss
can lead to massive infection
Third-degree burns regeneration
slow, grafting may be necessarym considerable scarring occurs
Bones are classified as
organs because they consist of osseous tissue and also contain cartilage, fibrous connective tissue, and nervous tissue.
The skeleton provides
a framework that supports the soft tissues of the body; protection; and surfaces for muscle attachments that are needed to move the body.
bones that protect examples
Cranium protects brain; vertebral column protects spinal cord; bony thorax protects heart and lungs; pelvic girdle protects reproductive and urinary organs
hemopoiesis
The skeleton carries out hemopoiesis, by which red bone marrow produces blood cells.
The skeleton stores
calcium, phosphorus, and other minerals needed for homeostasis; and stores energy in the adipose tissue found in yellow bone marrow.
Long bones
have greater length than width and they are slightly curved for strength.
_______________ is prevalent, but _________________ is present at both ends
compact bone; spongy bone
distal and proximal ________________ are separated by a ___________________
epiphyses (ends); diaphysis (shaft)
long bone shaft covering
covered by a tough periosteum with fibrous layer of dense irregular connective tissue and osteogenic layer containing bone-forming cells
Periosteum
protects bone, helps nourish bone tissue, assists in repairing functions
medullary cavity
runs the length of the diaphysis; filled with bone marrow