Exam 3 Flashcards
T3
stimulates metabolism
T4
inactive until converted into T3 by the tissues
Iodine and tyrosine
needed to make TH
hypothalamus anterior pituitary and the thyroid
can all lead to thyroid problems
primary thyroid dysfunction
problem with thyroid
primary hyperthyroid
TSH is low and TH is high
primary hypothyroid
TSH is high and TH is low
secondary thyroid dysfunction
problem due to pituitary gland
secondary hyperthyroid
TSH is high and TH is high
secondary hypothyroid
TSH is low and TH is low
tertiary thyroid dysfunction
due to hypothalamus
increase TRH —->
TSH ——> TH
Increase metabolic rate
decrease TH —- TRH —– TSH
women are ____ times more likely then men to have thyroid imbalance
5-10
hypothyroidism
can be congenital (cretinism) or acquired (hashimoto thyroiditis or thyroidectomy)
hyperthyroidism
can be graves disease or thyroid tumors, can cause a goiter, everything becomes excited
hashimoto thyroiditis
autoimmune disease, destruction of thyroid, 20’s or 50s-60s
graves disease
bug eyes, can be in 20s or 40s
causes of hypothyroidism
absence of the thyroid gland, lack of insufficient iodine in diet, autoimmune disorder, lack of TSH (pituitary gland disease), lack of TRH ( tumor or disorder of hypothalamus)
signs of hypothyroidism
lethargy hypotension hypoventilation slow GI intolerance to cold
cretinism
child with hypothyroidism, untreated leads to poor growth and development, preventable with hormone replacement
myxedema
life threatening, severe adult hypothyroidism
myxedema coma
end stage of hypothyroidism, life-threatening, most often in elderly women, 30% mortality rate
levothyroxine (synthroid, levonoxyl)
synthetic T4, given PO unless myxedema (given IV), can cause symptoms of hyperthyroidism, BLACK BOX- use for weight loss is contraindicated, take the same time each day with a full glass of water on empty stomach 30 minutes prior to eating
contraindications of TH
known allergy thyrotoxicosis (thyroid storm) hyperthyroidism acute MI, caution with lactation (still can give)
Thyroid storm or crisis
extreme manifestation of hyperthyroidism, caused by untreated hyperthyroidism precipitated by stress, manifested by high fever (NO aspirin) tachycardia MI coma delirium, 80-90% mortality if not treated
thyroidectomy
take out thyroid, increased TH right after surgery, airway issues, can save parathyroid (if not watch serum calcium, can drop), increased potential to bleed (watch for frequent swallowing)
anti-thyroid agent
prevent iodine from getting into the thyroid and partially inhibits conversion of T4 to T3, used for hyperthyroidism. if needed during pregnancy use PTU, can cause thyroid suppression development of goiter, iodine drugs can cause metallic taste and staining of teeth
propylthiouracil PTU
drug of choice for children used for hyperthyroidism, inhibits synthesis of TH and conversion of T4 to T3, therapeutic effect can be delayed for 3 weeks, can cause leukopenia or hepatotoxicity, given 3-4 times daily
methimazole (Tapazole)
used to treat hyperthyroidism by inhibiting production of TH, more bone marrow suppression, used in management of thyroid storm (bc can be given PO or IV), less likely to cause GI effects, less likely to induce hypothyroidism
sodium Iodine 131
radioactive, given for hyperthyroid, used in adults over 30, NOT in pregnancy may have adverse effects on fertility, used for thyroid destruction, limited contact with patient for only 1 hr per day, no contact with pregnant women or children
potassium iodide (lugol’s solution)
used for acute thyrotoxicosis, immediately blocks release of TH, can be used to make meth
Iodine solutions
contraindicated with pregnancy and Pulmonary edma/TB, adverse effects can stain teeth (drink through straw behind teeth) toxicity/ iodism
Calcium
found in bones, reciprocal relationship with phosphate, normal level 8.6- 10.2 total, transmission of nerve impulses, blood clotting
if PTH is taken out _____ type symptoms
hypocalcemia
functional tumor
secretes hormones
non-functional tumor
grows and presses on gland = hypo___
hypoparathyroidism
decreased PTH, decreased serum calcium, can be related to thyroidectomy parathyroidectomy or radical neck dissection, can be autoimmune, can manifest as hypocalcaemia
hyperparathyroidism
increased PTH, can be related to PTH tumor, can be secondary to renal failure or malabsorption of calcium, more common in women, more common over 50, patient will have hypercalcemia, demineralization of bone
Vitamin D therapy
increase absorption of calcium, indicated for hypocalcemia renal failure hypoparathyroidism, teach pt to increase weight bearing and the decrease consumption of alcohol and smoking
calcitrol (rocaltrol)
active form of vitamin D, need 400-600 units of vitamin D per day, decreased bone reabsorption , promotes calcium absorption in the gut and renal reabsorption of calcium
other forms of vitamin D
ergocalciferol, calcifediol, dihydrotachysterol
biphosphonates
act on calcium levels, lower serum calcium, can cause paget disease (demineralizes bone) or osteoporosis, contraindicated with pregnancy renal dysfunction or upper GI disease, can cause esophageal erosion (take in the morning sitting up with glass of water, don’t eat or drink for 30 minutes after
list of biphosphonates
etidronate (didronel), ibandronate (Boniva) taken monthly, pamidronate (Aredia) taken weekly, risedronate (Actonel) taken weekly, alendronate (Fosamax) taken weekly
raloxifene (Evista)
selective estrogen receptor modulator, prevents osteoporosis by increasing estrogen receptors on bone and increasing bone density, PO can cause hot flashes,
Denosumab (prolia)
monoclonal antibody prevents bone reabsorption, given subQ every 6 months
Teriparatide
stimulates bone formation, derivative of PTH
Calcitonin
hormones secreted by the thyroid gland to balance effects of PHT, inhibits bone reabsorption, increased secretion of calcium, emergency treatment of hypercalcemia, calcitonin -salmon nasal spray no used a lot linked to cancer
Calcitonin is released when
Serum Calcium levels are high
androgens
Male and female sex hormones (estrogen and testosteron)
Glucocorticoids (cortisol)
Stimulate an increase in glucose levels for energy, Increased breakdown of fat, Increase protein breakdown, decrease protein synthesis, Stress hormones, Suppression of inflammatory and immune responses
Mineralocorticoids (aldosterone)
Affect fluid and electrolyte levels, Causes the reabsorption of sodium and water and the elimination of potassium
CRH —> ——->
ACTH, cortisol
increase cortisol =
decrease CRH and ACTH which shuts down loop (why we tapper doses)
anti-inflammatory corticosteroids
supresses the leukocytes and chemical mediators in the inflammatory responce
immunosuppressive corticosteroids
supresses humoral and cell mediated immunity
maintenance of normal BP with corticosteroids
Enhance vasoconstriction (norepinephrine) Cause reabsorption of sodium and water and elimination of potassium (aldosterone-mineralocorticoid)
carbohydrates and metabolism with corticosteroids
Increased glycogenolysis and insulin resistance
Increase breakdown of protein (for gluconeogenesis)
Mobilize free fatty acids and redistribute fat
therapeutic uses of corticosteroids
Hormone replacement for adrenocortical insufficiency, Suppression of allergic reactions (Anaphylaxis and Drug reaction), Suppression of inflammatory disorders (RA, SLE, Inflammatory bowel disease, OA), Autoimmune disorders (Hashimoto’s thyroiditis), pulmonary disorders, prevention of transplant rejection, can decrease pain from inflammation
Adverse effects of corticosteroids
Hypokalemia, GI distress (prone to PUD), Muscle atrophy and weakness, Mood changes, insomnia, fatigue, Hyperglycemia, Fat redistribution to trunk and face, immunosupressive, suppress the release of ACTH, hypocalcemia, hypertension, weight gain, inhibit antibody responce to vaccines, protein depletion (osteoporosis), frail skin
contraindications of corticosteroids
acute infections, allergy and lactation, Caution in pregnancy (unless benefit to mother clearly outweighs risk to baby), diabetes (increase BG), peptic ulcer disease (increase irratation to the stomach)
name corticosteroids
betamethasone (Celestone), budesonide (Rhinocort) – rhinitis (intranasal), dexamethasone (Decadron) – inflammatory disorders (long acting), triamcinolone (Aristospan) – asthma, methylprednisolone (Medrol), prednisone (Deltasone), hydrocortisone (Cortef, Solu-Cortef) (has mineralocorticoid activity), prednisolone (Delta-Cortef), cortisone (has some mineralocorticoid activity)
nursing care with corticosteroids
use as low of dose as possible, take in the morning with food, may need vitamin D and calcium replacement, wean from drug, high protein calcium and potassium low sodium diet
mineralocorticoids
cortisone (Cortisone Acetate) (has some glucocorticoid activity as well) short acting (orally and parenterally), hydrocortisone (has some glucocorticoid activity as well) short acting, Fludrocortisone (Florinef)- small doses produce sodium retention, increased excretion of potassium and elevate BP. May be combined with glucocorticoid. given for fainting problem
mineralocorticoids contraindications and adverse reactions
Contraindications- Hypersensitivity, Heart failure, hypertension
Adverse Reactions- Increase fluid volumes, Allergic reactions, Hypokalemia
calcium is needed to
initiate the release of neurotransmitters into the synaptic space
three main types of neurotransmitters
Aminoacides (ex. Gamma aminobutyric acid [GABA}*** inhibits the CNS )
Peptides (endorphins, enkephalins, substance P- pain responce)
Monoamines (serotonin, dopamine, norepinephrine