Exam 1 Flashcards
pathophysiology
the study of altered health; the cellular and organ changes w/ disease and the effect that they have on the whole body
disease
interruption in normal body function
etiologic factors
thing that cause the disease to occur
risk factors
things that increase potential for development of disease
clinical manifestations
what does the disease present
signs
objective; something observer sees
symptoms
subjective; what patient says
syndrome
a lot of signs and symptoms together
complications
something happens b/c of the disease or treatment
sequelae
impairment following or are caused by disease
pharmacology
the study or science of drugs
pharmacotherapeutics
drug therapy; same drug may have different effects depending on patient factors (ex. age)
therapeutic effect
positive effect
adverse effect
negative effect
pharmacogenomics
influence of genetic factors on response to drugs
pharmaceutics
science of preparing and dispensing drugs
pharmacoeconomics
study of economic factors impacting the cost of drug therapy
pharmacognosy
study of drugs obtained from plant or animal source
toxicology
study of toxic drug effects and methods to manage
indication
why the drug is being used (condition)
prototype
agent to which all other drugs in the classification are compared.
combination drugs
drugs with more than one active ingredient
prodrug
inactive before metabolized
contraindication
condition that makes the drug potentially harmful to the patient
brand name
owned by company (capitalized)
generic name
name of the drug (lower case)
bioavailability of the drug
amount of the drug that can be used by the tissues; IV= 100%
pregnancy category A
studies in pregnant women have not shown a risk to the baby
pregnancy category B
animal studies, no risk, no sufficient evidence to show risk in animal or pregnant women
pregnancy category C
animal studies show risk, no human studies; use may be acceptable
pregnancy category D
evidence that risk but benefit may outweigh the risk
pregnancy category X
studies show fetal abnormalities or reaction. risk outweighs benefit
controlled substances are classified by their
abuse potential, defined control of distribution, storage, dispensing and use.
Schedule I
dispensing restrictions are only with approved protocol and an example is heroin or marijuana. the illegal drugs
Schedule II
dispensing restrictions are with written prescription only with no refills and must have a warning label, an example is cocaine or codeine.
Schedule III
dispensing restrictions are with written or oral prescription that expires in 6 months with no more than 5 refills in 6 months and must have a warning label, an example is hydrocodone.
Schedule IV
dispensing restrictions are with written or oral prescription that expires in 6 months with no more than 5 refills in 6 months and must have a warning label, an example is phenobarbital.
Schedule V
is with prescription or over the counter (can vary with state law), an example is cough medicine.
which route you use for the drug depends on
how quick it is absorbed
sublingual is _____ absorption than buccal due to the amount of blood flow
faster
pharmacodynamics
what the drug does to the body, the therapeutic effect
Pharmacokinetics
what the body does to the drug, example peak effect, absorption metabolism
pharmacokinetical processes determine
onset of drug, action, peak drug effect and duration of drug action
four main processes of pharmacokinetics
absorption (onset of drug action), distribution, metabolism (by the liver), excretion (by the kidneys, bile, lungs)
absorption of the drug
determines onset of action; affected by route of administration
oral medications can be affected by
presence of food or other drugs in the stomach (fatty foods slow absorption), acidity of the stomach (breaks down compounds), motility of the GI tract (anti-cholinergics slow peristalsis), and blood flow of the GI
first pass effect
extent to which the drug is metabolized in the portal circulation prior to being absorbed into the systemic circulation
increased first pass effect equals
higher concentration of the drug (cant be given orally if first pass is too large)
depot drugs
slow absorption of drug over days/ months/ longer (some types of birth control)
for injections increase heat means
increased blood flow and increased onset
if the drug is stored (mostly in fat) there is ____ duration
increased
if bound to protein the drug is
inactive
when unbound drug (active) goes into the tissues, drug concentration decreases and
inactive drugs unbind from the protein
if the patient has low protein levels, there will be higher amounts of unbound proteins which leads to
toxicity
more bound drug means
an increase in duration
drugs that are highly lipid soluble are ____ likely to pass through the BBB and reach the CNS
more
biotransformation
the liver is the most important site, breaks down meds, Cytochrome P450 enzyme is responcible for most drug metabolism
steady state (therapeutic range)
when the amount of drug absorbed equals the amount of drug excreted; maximum therapeutic effect at this level, can only occur with repetitive administration
therapeutic drug monitoring
monitoring plasma levels of drugs with low safety margins (peaks and troughs)
therapeutic index
how quick the drug goes from minimum effectiveness to toxicity, larger number= safer dose
drugs act by
receptors, enzymes, nonselective interactions
efficacy
greatest maximal response that can be produced from a particular drug
receptor interactions
tighter fit = stronger reaction, lock (cell receptor site) key (drug)
agonist
binds to the receptor and cause natural response
partial agonist
causes the agonist response but not as strong
antagonist
causes the opposite response of natural chemicals (blocks any response) or competes with other drugs for same receptors
selective toxicity
when drug attacks only foreign cells, not healthy cells
nonselective interactions
target is cell membrane or metabolic activity in the cell
factors influencing drug effect
patient condition, psychological factors (placebo effect), drug dependence, drug tolerance
acute therapy
immediate, intensive drug treatment for the critically ill (OJ for low blood sugar)
maintenance therapy
to prevent progression of disease (anti-hypertensive for high BP)
supplemental therapy
supplies the body with what is needed for normal function (insulin)
palliative therapy
relief of pain, to improve quality of life
supportive therapy
maintains body functions when patient is recovering from illness (IV fluids)
prophylactic therapy
prevent illness (antibiotics before surgery)
empiric therapy
based on probabilities (treat pneumonia before culture is back)
adverse drug events
undesirable occurrence involving meds, can be non/preventable, can be from med error or just from the medication dose
idiosyncratic reaction
not the result of something known about the drug and not the result of an allergy, unexpected reaction
black box warning
significant potential for adverse effect
teratogenicity
any drug that causes harm to developing fetus or embryo
presence of food can ___ absorption and drug effect
decrease