Exam 2 - Two-Compartment Model: IV Bolus

Question 1

What are the two-compartments?

Answer 1

Central (plasma) & Peripheral (tissue)

Question 2

In which compartment does elimination occur?

Answer 2

Central (plasma)

Question 3

Dependent Variables

Answer 3

Cp & Ct

Question 4

Independent Variable

Answer 4

t

Question 5

Parameters

Answer 5

Cp0, k12, k21, k10

Question 6

Drug is administered into which compartment?

Answer 6

Central (plasma)

Question 7

What are the “transfer” rate constants?

Answer 7

k21, k12, k10

Question 8

What are the apparent rate constants?

Answer 8

alpha & beta

Question 9

Vp

Answer 9

volume of the plasma compartment

Question 10

Vt

Answer 10

volume of the tissue compartment

Question 11

Vp + Vt

Answer 11

total volume

Question 12

What is assumed about the apparent rate constants?

Answer 12

beta < alpha

Question 13

What is the distribution phase effected by?

Answer 13

alpha & beta

Question 14

What is the elimination phase effected by?

Answer 14

beta only

Question 15

Vd(ss)

Answer 15

Volume of distribution at steady state

Question 16

Vd(exp)

Answer 16

Extrapolated volume of distribution

Question 17

Vd(B)

Answer 17

Volume of distribution by area

Question 18

Vp equation

Answer 18

Vp = D(0)/(A+B)

Question 19

Vd(exp) equation

Answer 19

Vd(exp) = D(0)/B

Question 20

What is Vp used for?

Answer 20

To estimate Cp immediately after the dose

Question 21

What is Vd(ss) used for?

Answer 21

To describe protein binding effects on distribution

Question 22

What is Vd (exp) used for?

Answer 22

To estimate drug in the body (D) during the elimination phase

Question 23

What is Vd(area) closely related to?

Answer 23

Overall CL (based on AUC)

Question 24

Compare Vd(exp), Vd(area), Vd(ss), & Vp

Answer 24

V(exp) > Vd(area) = Vd (ss) > Vp

Question 25

t1/2 equation

Answer 25

t1/2 = 0.693/beta

Question 26

What is the half-life known as in this model?

Answer 26

Terminal half-life

Question 27

CL equation

Answer 27

CL = D(0)/[AUC]