Exam 2 - Oral Dosing Flashcards
1
Q
Absorption phase
A
increasing part of the Cp vs t curve
2
Q
Elimination phase
A
decreasing part of the Cp vs t curve
3
Q
Cmax,tmax
A
the maximum in the Cp vs t curve
4
Q
Cp (initial plasma concentration) in oral dosing
A
Cp0 = 0 because the drug has not immediately entered the bloodstream when the dose is given
5
Q
Assumptions made about th rate constant k
A
assume that the absorption rate (ka) is greater than the elimination rate (ke)
6
Q
New variable: F
A
oral bioavailability
7
Q
New variable: Ke
A
elimination rate constant
8
Q
New variable: Mb(t)
A
mass of drug in body
9
Q
tmax
A
time to reach peak plasma concentration
10
Q
tmax is independent of ____
A
F (oral bioavailability)
11
Q
tmax is dependent on ____
A
ke, ka, Vd, CL
