Exam 2 - Non-Compartmental Pharmacokinetics

Question 1

What is another name for non-compartmental PK?

Answer 1

Statistical Moment Theory

Question 2

MRT

Answer 2

Mean residence time

Question 3

First moment (mean)

Answer 3

central tendency, expected value

Question 4

Second moment (standard deviation)

Answer 4

breadth of the distribution

Question 5

Third moment (skewness)

Answer 5

symmetry of the distribution

Question 6

Fourth moment (kurtosis)

Answer 6

peakedness of the distribution

Question 7

MRT equation

Answer 7

AUMC/AUC

Question 8

AUMC

Answer 8

Area under the moment curve

Question 9

MAT (mean absorption time)

Answer 9

the difference in MRT for an orally administered dose and an IV dose

Question 10

MDT (mean dissolution time)

Answer 10

the difference in MRT for an orally administered solution and an orally administered tablet

Question 11

V(ss) equation

Answer 11

V(ss) = CL x MRT

Question 12

CL equation

Answer 12

CL = dose/AUC

Question 13

Advantages of MRT Method (5)

Answer 13

• One approach applies for all routes of administration, curve shapes, and patients
• A compartmental model is not imposed, and regression analysis is not needed
• Quantitative estimates of in vivo absorption time(MAT) and dissolution time(MDT) are possible
• Calculation of CL is relevant for all PK models
• Calculation of V(ss) is easy & there’s only one

Question 14

Disadvantages of MRT method (3)

Answer 14

• Assumptions of linearity must be applied to estimate AUC & AUMC to t=infinity
• Difficult to use this approach to predict Cp vs t for a different dosing regimen
• Compartment-based concepts, like Vd, are still used