Exam 2 Test Flashcards
What is Osmosis?
The movement of the water portion of plasma across either the capillary or cell membranes from high concentration to low concentration
What is Diffusion?
The movement of the particulate matter portion of plasma across either the capillary or cell membranes from high concentration to low concentration
What is the “passive process” of osmosis and diffusion?
Moves with the concentration gradient with requires no external energy
What is the “dynamic equilibrium” of osmosis and diffusion?
Continually moves with the concentration gradient until reaching equality on both sides of the membranes
Is osmosis and diffusion fast or slow over short distances?
Fast
What is osmosis and diffusion dependent on?
Dependent upon temperature, size of the concentration gradient, and size of the particle
What is Molarity?
Purified compound in some volume of water (mol/L = Moles per Liter)
What is Osmolality?
- Quantity of a particulate matter dissolved in the water portion of plasma
- Measured in Milliosmoles (mOsm)
- Range is 270-290 mOsm (286 mOsm is gold standard)
What are Equivalents?
- Modality X ion charge
- Milliequivalents (mEg/L)
- mEg/L is used to measure individual ions
What are the 3 Fluid Compartments?
- Capillary Space: Represents Circulation
- Interstitial Space: Represents area BETWEEN the cells
- Intracellular Space: Represents area INSIDE the cell
What is the Capillary Membrane Rule?
Capillary membrane allows all things to pass through except large proteins called ALBUMIN
Albumin attracts water from ________ space filling up the ______ space, creating the normal blood pressure in circulation
Interstitial ; Capillary
- Increase Albumin = ?
- Decrease Albumin = ?
- Increase Blood Pressure
- Decrease Blood Pressure
What is the Cell Membrane Rule?
Does not allow all things to pass through except for water and sometimes Na+
Compare and Contrast the Capillary and Interstitial Compartments
- Equality with osmolality (both 286 mOsm)
- Capillary space contains Albumin which attracts water setting the blood pressure
- The ions of Na+, K+, Ca2+, and Cl- are identical/nearly identical between the 2 compartments
Compare and Contrast the Intracellular Space to the Interstitial and Capillary Spaces
- Equality with osmolality (all 3 compartments have 286 mOsm)
- The ions of Na+, K+, Ca2+, and Cl- are very different in concentration allowing us to separate ions to build the biological battery
What are the 4 components of Freshwater Drowning?
- Freshwater enters the lung capillaries and causes a severe hypoosmotic condition in the capillary space
- Osmosis occurs between the capillary and interstitial space causing a severe hypoosmotic condition in the interstitial space
- Osmosis occurs between the interstitial and intracellular space causing a severe hypoosmotic condition in the intracellular space
- Cell Lysis: The cell fills up with water and increases pressure beyond the cell’s membrane capacity and ruptures
What are the 4 components of Saltwater Drowning?
- Saltwater enters the lung capillaries and causes a severe hyperosmotic condition in the capillary space
- Diffusion of Na+ occurs between the capillary and interstitial spaces causing a severe hyperosmotic condition in the interstitial space
- Osmosis occurs between the intracellular and ECF spaces causing a severe hyperosmotic condition in the intracellular space
- Cell Creation: The excess water in the cell exits the cell trying to reach dynamic equilibrium with the ECF causing the cell to shrink
What are the 4 components of Kwashiorkor Disease?
- Severe protein malnutrition reduces the production of albumin proteins causing a reduction of albumin in the capillary space which then creates a slight hypoosmotic condition in the capillary space
- Osmosis occurs between the capillary and interstitial spaces causing a slight hypoosmotic condition in the interstitial space
- Osmosis occurs between the interstitial and intracellular space causing a slight hypoosmotic condition in the intracellular space
- Vascular collapse: The water exits the capillary space over time reducing the plasma portion of blood leading to vascular collapse when severe enough
What are the 2 Major Categories of Protein Structures in the Membranes?
- Extrinsic, Peripheral, Associated Proteins
- Intrinsic, Transmembrane, Integral Proteins
Extrinsic, Peripheral, Associated Proteins of Protein Structures in the Membranes are characterized by….?
Sticking only part way into the phospholipid bilayer