Exam 2 - stuff

Question 1

2 net effects of asthma

Answer 1

1) bronchoconstriction

2) inflammation and swelling of airways

Question 2

cardiac output =

Answer 2

stroke vol x HR

Question 3

preload

Answer 3

force of venous return

Question 4

afterload

Answer 4

arterial pressure

Question 5

arterial pressure

Answer 5

= peripheral resist x CO

Question 6

ACE catalyzes what to what

Answer 6

ANG 1 to ANG 2

Question 7

what type of drugs reduce risk of cardio mortality caused by hypertension?

Answer 7

ACE inhibitors

Question 8

ARBs

Answer 8

block the action of ANG II

- “SARTAN”

Question 9

why not take beta blocker with cardiac failure stuff people?

Answer 9

beta blockers have same effects as calcium channel blockers

- = decreased contraction

Question 10

Heparin

unfractionated vs low-molecular wt

Answer 10

unfract: inactivates clotting factors, suppresses fibrin formation. need lab monitoring

LMW - need lab monitoring. DVT stuff

Question 11

Antagonist of vit K

Answer 11

warfarin

Question 12

drugs to cross BBB

Answer 12

need to be lipid soluble

Question 13

General vs partial seizures

Answer 13

General = both sides of brain

Partial = only small part

Question 14

how does antidepressants work?

Answer 14

inc NT
over stim
down regulates and dec sensitivity

Question 15

tricyclic antidepressants MOA

Answer 15

block uptake 1

Question 16

BDZ act on ?

Answer 16

Freq of GABA channels

Question 17

barbiturates act on?

Answer 17

duration of GABA channels

Question 18

Extrapyramidal actions (4)

Answer 18

dystonias - muscle spasm
parkinsonism - like disease
akathisia - restless movement
tardive dyskinesia - oral, facial movements

Question 19

neurodegeneration

Answer 19

death through

• excitotoxicity
• deplete ATP
• oxidative stress

Question 20

Wernicke’s encephalopathy

Answer 20

thiamine deficiency results in confusion. reversible

Question 21

korsakoff’s psychosis

Answer 21

inability to convert short term to long. irreversible.

Question 22

schizo (matching)

Answer 22

overactive dopamine

Question 23

Parkinson’s (matching)

Answer 23

shortage of dopamine

Question 24

alzheimer’s (matching)

Answer 24

cholinergic insufficiency

Question 25

ALS (matching)

Answer 25

peripheral neurons

Question 26

special concerns for pt on antidepressants during PT

Answer 26

-sedation
weakness
lethargy
orthostatic hypotension

Question 27

Cyctic fibrosis drug combo

Answer 27

mucolytic drugs and cortiosteroids

Question 28

renin catalyzes

Answer 28

angiotensinogen to Ang 1

Question 29

ACE inhibitors adverse effects

Answer 29

First dose hypotension

cough