Exam 2 (Lecture 15) - Chronic Inflammation Flashcards
What are the two underlying , often concurrently, processes that imply chronic inflammation?
1) Fibroplasia
2) Cellular infiltration
What is fibroplasia?
Formation of fibrous connective tissue, newly formed “immature” connective tissue with newly formed blood vessels.
- and “mature” connective tissue that contains well-collagenized and remodeled granulation tissue
What are cellular infiltrates?
Predominantly macrophages, lymphocytes, and plasma cells, depending on the inciting agent/substance and the duration.
What is a lesion called when lymphocytes and macrophages predominate over plasma cells?
Lymphohistiocytic
What are the types of inflammation associated with chronic inflammation?
1) Fibrosing
2) Chronic-active
3) Granulomatous
4) Pyogranulomatous
5) Granulomas
6) Pyogranuloma
What is fibrosing inflammation composed of?
Fibrous connective tissue
What is chronic-active inflammation?
Has the same cellular components as chronic inflammation but also contains neutrophils, fibrin, and plasma proteins that are constituents of the acute inflammatory response.
What is granulomatous inflammation?
Has a basic cellular exudate consisting predominantly of activated macrophages and in some cases also epithelioid macrophages MGCs, and lesser numbers of lymphocytes and plasma cells.
What is pyogranulomatous inflammation?
Same cellular exudate as granulomatous inflammation but also contains multifocal/random infiltrates of neutrophils, fibrin, and plasma proteins which are constituents of the acute inflammatory response.
- mostly neutrophils and macrophages
What are granulomas?
Distinct type of granulomatous inflammatory response that occurs when macrophage infiltration is present in a well-defined area and thus the aggregated macrophages form a distinct mass on gross observation.
What is a pyogranuloma?
A nodular granuloma with a central area of neutrophils.
