Exam 2 - Healing & Repair Flashcards
healing and repair steps
- parenchymal regeneration
- regeneration & fibrosis
- replacement by fibrous tissue (stroma network destroyed, permanent cell population damaged, exudate can not be reabsorbed)
permanent cell types (no replication)
myocytes
neurons
stable cell types (capable but less mitosis)
osteoblasts
epithelial cells of parenchymal/endocrine organs (adrenal, pit, thyroid, kidney, liver, pancrease, glands, etc.)
fibroblasts
endothelial cells
skeletal/smooth m.
chondrocytes (proliferation but not much replication)
labile cell types (frequent replication)
epithelium of GI, repro, external skin
blood cells
phases of healing and repair
inflammation
cell migration
matrix deposition (collagen)
vascular proliferation
collagen synthesis
remodeling
primary healing intention
wound edges opposed, rapid healing with minimal scar tissue
secondary intention healing
defect filled with granulation tissue; prolonged course and potential scarring
what is known as proud flesh
excess granulation tissue
raised scar that remains within the wound margin; occurs in animals
hypertrophic scar
raised scar that extends beyond the original wound margin; only humans
keloid
healing between serosal surfaces
adhesion
joint is fixed in place such as due to injury to joint (e.g. fixed hyperextension of fetlock due to frostbite)
ankylosis
scars become smaller overtime
contracture
luminal structure with too small of opening (e.g. pyloric ulcer –> smaller pyloric sphincter)
stricture
Describe how a fibrinous adhesion might become a fibrous adhesion.
fibrinogen polymerized to fibrin = fibrinous exudate/adhesion
fibrous connective tissue composed of collagen + fibroblasts + endothelial cells which will then adhere organs to body walls (examples)
