Exam 2 drugs Flashcards
albuterol
SABA
asthma, COPD
levalbuterol
SABA
asthma, COPD
ipratropium
SAMA
asthma, COPD
prednisone, dexamethasone
systemic corticosteroids
asthma, COPD
budesonide
ICS
asthma, COPD
fluticasone
ICS
asthma, COPD
ciclesonide
new ICS
asthma
salmeterol
LABA
asthma, COPD
formoterol
LABA
asthma, COPD
tiotropium
LAMA
asthma, COPD
cromolyn
cromoglycates - alter function of chloride channels – inhibit cellular activation
asthma
theophylline
methylxanthines - inhibits PDE = bronchodilator
asthma
zileuton
leukotriene modifier- 5- lipoxygenase inhibitor
asthma (not used)
zafirleukast
leukotriene modifier - cysteinyl leukotriene-receptor antagonist
asthma (not used)
Montelukast
leukotriene modifier - cysteinyl leukotriene-receptor antagonist
asthma (+allergic rhinitis)
umeclidinium
LAMA
COPD
aclidinium
LAMA
COPD
revefenacin
LAMA
COPD
glycopyrrolate
LAMA
COPD
oldaterol
LABA
COPD
arfomoterol
LABA
COPD
Roflumilast
inhibits PDE4 = decreases inflammation
severe COPD with bronchitis & AE-COPD
DM
cough
benzonatate
polyglycol derivative
cough
guaifenesin
expectorant for cough
antihistamines
antimuscarinic effects for cough
decongestants
decrease PND for cough
bupropion
smoking cessation, MDD, seasonal affective disorder
*dont give with anxiety! or seizure hx
calcium
osteoporosis (1000-1200)
HRT
estrogen +/- progestin
not 1st line for osteoporosis - now causes VTE, CA, CVA
tamoxifen
SERM - selective estrogen receptor modulator
osteoporosis
raloxifene
SERM - selective estrogen receptor modulator
osteoporosis
denosumab
anti-rank ligand - prevents preosteoclasts–>osteoclasts
osteoporosis, mets from solid tumors
alendronate
bisphos - incorporates into bone, gets released by osteoclasts = osteoclast apoptosis
osteoporosis
risendronate
bisphos - incorporates into bone, gets released by osteoclasts = osteoclast apoptosis
osteoporosis
zoledronic acid
bisphos - incorporates into bone, gets released by osteoclasts = osteoclast apoptosis
osteoporosis
teriparatide
PTH/PTHrP analog - increases osteoblasts, increase Ca2+ in GI tract and kidney
osteoporosis with high risk of fracture
aboloparatide
PTH/PTHrP analog - increases osteoblasts, increase Ca2+ in GI tract and kidney
osteoporosis with high risk of fracture
romosumab
sclerostin inhibitor - stimulates osteoblasts
osteoporosis
levothyroxine
T4–>T3
hypothyroidism
liothyronine
T3
hypothyroidism
liotrix
T3 & T4
hypothyroidism
PTU
thionamide - blocks conversion in thyroid and liver
hyperthyroidism in 1st trimester pregnancy, thyroiditis (thyroid storm)
methimazole
thionamide - blocks conversion just in thyroid
hyperthyroidism
RAI
sodium iodine I-131 - inflammation = destroys thyroid
hyperthyroidism
steroid for hyperthyroidism sxs
dexamethasone
metformin
biguanides- decreases hepatic glucose production, increases GLP1
pre-DM, DM, PCOS
glyburide
sulfonyurea- binds ATP K+ channel = increased insulin secretion
DM (not used)
glimepiride
sulfonyurea - binds ATP K+ channel = increased insulin secretion
DM (not used in elderly)
glipizide
sulfonyurea OF CHOICE - binds ATP K+ channel = increased insulin secretion
DM
nateglinide
meglitinides - binds ATP K+ channel = increased insulin secretion
DM
repaglinide
meglitinides - binds ATP K+ channel = increased insulin secretion
DM
pioglitazone
TZD - ppar-y agonist
DM (favorable lipid effects)
rosiglitazone
TZD - ppar-y with ppar-a activity
DM
acarbose
alpha-glucosidase inhibitor - decreases glucose absorption at SI brush border
DM
miglitol
alpha-glucosidase inhibitor - decreases glucose absorption at SI brush border
DM
liraglutide
GLP-1 agonists - stimulates insulin, inhibits glucagon secretion, hepatic glucose production, gastric emptying, appetite
DM, *weight loss
semaglutide
GLP-1 agonists - stimulates insulin, inhibits glucagon secretion, hepatic glucose production, gastric emptying, appetite
DM - *most potent A1C lowering
exenatide
GLP-1 agonists - stimulates insulin, inhibits glucagon secretion, hepatic glucose production, gastric emptying, appetite
DM
lixisenatide
GLP-1 agonists - stimulates insulin, inhibits glucagon secretion, hepatic glucose production, gastric emptying, appetite
DM
dulaglutide
GLP-1 agonists - stimulates insulin, inhibits glucagon secretion, hepatic glucose production, gastric emptying, appetite
DM
sitagliptin
DPP-4 inhibitor - prolong active incretin levels
DM
saxagliptin
DPP-4 inhibitor - prolong active incretin levels
DM
linagliptin
DPP-4 inhibitor - prolong active incretin levels
DM
alogliptin
DPP-4 inhibitor - prolong active incretin levels
DM
canagliflozin
SGLT-2 inhibitor - decreases glucose and Na reabsorption, increase urinary glucose/Na excretion
DM
empagliflozin
SGLT-2 inhibitor - decreases glucose and Na reabsorption, increase urinary glucose/Na excretion
DM *agent of choice!!
ertugliflozin
SGLT-2 inhibitor - decreases glucose and Na reabsorption, increase urinary glucose/Na excretion
DM
dapagliflozin
SGLT-2 inhibitor - decreases glucose and Na reabsorption, increase urinary glucose/Na excretion
DM
regular insulin
fast-acting insulin
lispro
faster-acting insulin
aspart
faster-acting insulin
glulisine
faster-acting insulin
NPH
intermediate insulin
detemir
long acting insulin
glargine
long acting insulin
degludec
long acting insulin
mannitol
diuretic
decrease ICP, TURP procedure
acetazolamide
diuretic
acute mountain sickness
furosemide
loop diuretic (loop of henle) pulmonary edema, other edema states, hypercalcemia
torsemide
loop diuretic (loop of henle) pulmonary edema, other edema states, hypercalcemia
bumetanide
loop diuretic (loop of henle) pulmonary edema, other edema states, hypercalcemia
ethancrynic acid
loop diuretic (loop of henle) pulmonary edema, other edema states, hypercalcemia
hydrochlorothiazide
thiazide diuretic (distal convoluted tubule) HTN
chlorthaldone
thiazide diuretic (distal convoluted tubule) HTN (more potent, longer 1/2 life)
metolazone
thiazide diuretic (distal convoluted tubule) HTN (synergistic with loops)
spironolactone
anti-aldo / K+ sparing diuretic - blocks at cortical collecting tubule
primary & secondary aldosteronism, hirsutism/acne
eplerenone
anti- aldo / K+ sparing diuretic - blocks at cortical collecting tubule
primary & secondary aldosteronism, hirsutism/acne
amiloride
K+ sparing diuretic - in distal tubule, cortical collecting tubule, collecting duct
with other diuretics to correct/prevent hypo K+
triamterene
K+ sparing diuretic - in distal tubule, cortical collecting tubule, collecting duct
with other diuretics to correct/prevent hypo K+
lisinopril
ACEi - inhibits angioten 1 –> angioten 2 & dilates efferent arteriole
HF with systolic dysfunction, HTN (LVH>), CKD, post-AMI
(ONLY QDAY)
enalapril
ACEi - inhibits angioten 1 –> angioten 2 & dilates efferent arteriole
HTN with systolic dysfunction, HTN (LVH>), CKD, post-AMI
losartan
ARB - inhibits binding of angiotensin to AT1 receptor = no vasoconstricting effects
HTN with systolic dysfunction, HTN, CKD, post-AMI
+ gout prevention!
candesartan
ARB - inhibits binding of angiotensin to AT1 receptor = no vasoconstricting effects
HTN with systolic dysfunction, HTN, CKD, post-AMI
valsartan
ARB - inhibits binding of angiotensin to AT1 receptor = no vasoconstricting effects
HTN with systolic dysfunction, HTN, CKD, post-AMI
aliskiren
renin inhibitor
HTN (but never used)
terazosin
long-acting alpha-blocker - blocks a1 = dilates resistance and capacitance vessels
BPH, medical expulsive therapy for ureteral stones, HTN, endocrine HTN
doxazosin
long-acting alpha-blocker - blocks a1 = dilates resistance and capacitance vessels
prazosin
short-acting alpha-blocker - blocks a1 = dilates resistance and capacitance vessels
propranolol
non-selective B-blocker
HTN, unstable angina, post-AMI, HFrEF, systolic HF, arrhythmias, perioperative, migraine prophylaxis, essential tremors, **infantile hemangiomas
timolol
non-selective B-blocker
HTN, unstable angina, post-AMI, HFrEF, systolic HF, arrhythmias, perioperative, migraine prophylaxis, essential tremors
nadolol
non-selective B-blocker
HTN, unstable angina, post-AMI, HFrEF, systolic HF, arrhythmias, perioperative, migraine prophylaxis, essential tremors
metoprolol
selective B-blocker
HTN, unstable angina, post-AMI, HFrEF, systolic HF, arrhythmias, perioperative, migraine prophylaxis, essential tremors
carvedilol
non-selective B-blocker w. alpha-activity
HTN, unstable angina, post-AMI, HFrEF, systolic HF, arrhythmias, perioperative, migraine prophylaxis, essential tremors
labetalol
non-selective B-blocker w. alpha activity
HTN, unstable angina, post-AMI, HFrEF, systolic HF, arrhythmias, perioperative, migraine prophylaxis, essential tremors
nebivolol
selective B-blocker (B3) + NO activity
HTN, unstable angina, post-AMI, HFrEF, systolic HF, arrhythmias, perioperative, migraine prophylaxis, essential tremors
nifedipine
short-acting DHP - CCB - inhibit L-type Ca channel in vascular smooth muscle = decreased PVR
HTN, angina, Raynaud
amlodipine
long-acting DHP - CCB - inhibit L-type Ca channel in vascular smooth muscle = decreased PVR
HTN, angina, Raynaud
verapamil
non-DHP CCB - blocks L-type Ca channel in heart = (-) ionotropic effect (more cardiac activity than diltiazem) cardiac arrhythmias (SVT, a-fib)
diltiazem
non-DHP CCB - blocks L-type Ca channel in heart = (-) ionotropic effect cardiac arrhythmias (SVT, a-fib)
hydralazine
direct vasodilator = decrease PVR
HTN, HF in blacks, eclampsia/preeclampsia
minoxidil
direct vasodilator = decrease PVR
HTN, alopecia, OSA, hyper aldosterone tumor
clonidine
central alpha-agonist - stimulates a2 receptors = decrease PVR, renal vascular resistance, HR, BP
HTN (patch)
methyldopa
central alpha-agonist - stimulates a2 receptors = decrease PVR, renal vascular resistance, HR, BP
HTN
rosuvastatin
hmg-coa reductase inhibitor - uptakes regulation of LDL = decreased serum LDL
LDL-lowering
simvastatin (+ when dosed)
hmg-coa reductase inhibitor - uptakes regulation of LDL = decreased serum LDL
LDL-lowering
dosed in AM (short 1/2 life)
atorvastatin
hmg-coa reductase inhibitor - uptakes regulation of LDL = decreased serum LDL
LDL-lowering
pitavastatin
hmg-coa reductase inhibitor - uptakes regulation of LDL = decreased serum LDL
LDL-lowering
pravastatin
hmg-coa reductase inhibitor - uptakes regulation of LDL = decreased serum LDL
LDL-lowering
lovastatin (+ when dosed)
hmg-coa reductase inhibitor - uptakes regulation of LDL = decreased serum LDL
LDL-lowering
dosed in AM (short 1/2 life)
fluvastatin (+ when dosed)
hmg-coa reductase inhibitor - uptakes regulation of LDL = decreased serum LDL
LDL-lowering
dosed in AM (short 1/2 life)
ezetimibe
cholesterol absorption inhibitor - inhibits intestinal absorption of dietary & biliary cholesterol
LDL-lowering
cholestyramine
bile acid sequestrant - conversion of bile –> cholesterol = increase LDL receptor synthesis –> decrease plasma LDL
LDL-lowering
colestipol
bile acid sequestrant - conversion of bile –> cholesterol = increase LDL receptor synthesis –> decrease plasma LDL
LDL- lowering
colesevelam
bile acid sequestrant - conversion of bile –> cholesterol = increase LDL receptor synthesis –> decrease plasma LDL
LDL-lowering
alirocumab
PCSK9 inhibitor - prevents PCSK9 from binding to LDL receptors = increased hepatic uptake of LDL-C
LDL- lowering (for familial hypercholesterolemia)
evolocumab
PCSK9 inhibitor - prevents PCSK9 from binding to LDL receptors = increased hepatic uptake of LDL-C
LDL- lowering (for familial hypercholesterolemia)
Niacin
inhibits synthesis and conversion of VLDL –> LDL
targets HDL & TG
fenofibrate
Ppar-a agonist - regulates gene that control lipid & glucose metabolism, inflammation, endothelial function
targets TG, *also for gout prevention
gemfibrozil
Ppar-a agonist - regulates gene that control lipid & glucose metabolism, inflammation, endothelial function
targets TG
fenofibric acid
Ppar-a agonist - regulates gene that control lipid & glucose metabolism, inflammation, endothelial function
targets TG
EPA/DHA
reduces hepatic TG production and increases TG clearance
aspirin
irreversibly acetylates COX = decreased platelet aggregation and vasoconstriction = irreversible platelet effect TIA/CVA/AMI prophylaxis (1* and 2*) ACS (DAPT) DVT prophylaxis analgesia
clopidogrel
ADP receptor inhibitor (thienopyridine) - prodrug though CYP2C19 (activated in liver) - irreversibly blocks P2Y12 component of ADP receptors
prasugrel
ADP receptor inhibitor (thienopyridine) - prodrug that is less dependent on CYP system -irreversible platelet effect
ticagrelor
ADP receptor inhibitor (non-thienopyridine)
same as clopidogrel/prasugrel but reversible
cangrelor
ADP receptor inhibitor (non-thienopyridine)
same as clopidogrel/prasugrel but reversible
warfarin
antagonizes VKORC1 - inhibits carboxylation of vit K factors (II, VII, IX, X) and anticoagulant factors (C&S)
AF with CAD, valvular AF, prosthetic valve AF
prevention and treatment of VTE
heparin
indirect thrombin inhibitor
systemic anticoagulation
DVT prophylaxis
anticoag for ECMO
rivaroxaban
oral factor Xa inhibitors (NOAC/DOAC)
VTE prevention in THA/TKA
non-valvular AFIB
prevention/tx of VTE
apixaban
oral factor Xa inhibitors (NOAC/DOAC)
VTE prevention in THA/TKA
non-valvular AFIB
prevention/tx of VTE
edoxaban
oral factor Xa inhibitors (NOAC/DOAC)
VTE prevention in THA/TKA
non-valvular AFIB
prevention/tx of VTE
betrixaban
oral factor Xa inhibitors (NOAC/DOAC)
VTE prevention in THA/TKA
non-valvular AFIB
prevention/tx of VTE
enoxaparin
LMWH - anti-thrombin mediated inhibition of Xa>IIa
VTE prevention in hip/knee surgery, abd sx, medical patients
VTE treatment
ACS
dalteparin
LMWH - anti-thrombin mediated inhibition of Xa>IIa
VTE prevention in hip/knee surgery, abd sx, medical patients
VTE treatment
ACS
vitamin K/PCC/FFP
reverses warfarin
protamine (sulfate?)
reverses UFH & LMWH
andexanet-a
reverses oral factor Xa inhibitors
idarucizumab
reverses Direct thrombin inhibitors
fondaparinux
factor Xa inhibitor
VTE prophylaxis for hip/knee, abd surgery
VTE treatment
dabigatran
direct thrombin inhibitor (DTI)
VTE prevention for TKA/THA
non-valvular AFIB
VTE treatment
argatroban
direct thrombin inhibitor (DTI)
HIT
desirudin
direct thrombin inhibitor (DTI)
DVT prophylaxis during THA
bivalirudin
direct thrombin inhibitor (DTI)
ACS pts managed with PCI, pts with or at risk for HIT/HITTS undergoing PCI
alteplase (tpa)
fibrinolytic (thrombolytics) - binds to fibrin in a thrombus & converts entrapped plasminogen to plasmin
STEMI, acute PE, acute ischemic stroke, central venous catheter clearance, acute peripheral arterial occlusive disease
tenecteplase
fibrinolytic (thrombolytics) - binds to fibrin in a thrombus & converts entrapped plasminogen to plasmin
longer 1/2 life than tpa
STEMI (only)
quinidine
Class IA anti-arrhythmic - modulate Na channels
procainamide
Class IA anti-arrhythmic - modulate Na channels
disopyramide
Class IA anti-arrhythmic - modulate Na channels
lidocaine
Class IB anti-arrhythmic - modulate Na channels
mexiletine
Class IB anti-arrhythmic - modulate Na channels
flecanide
Class IC anti-arrhythmic - modulate Na channels
propafenone
Class IC anti-arrhythmic - modulate Na channels
sotalol
Class III anti-arrhythmic - block K+ channels
ilbutilide
Class III anti-arrhythmic - block K+ channels
dofetilide
Class III anti-arrhythmic - block K+ channels
amiodarone
Class III anti-arrhythmic - block K+ channels
life-threatening or hemodynamically unstable VT
unlabeled: recurrent AF, AF prophylaxis following open heart surgery
dronedarone
Class III anti-arrhythmic - block K+ channels
A-FIB/a-flutter
digoxin
advanced systolic HF: blocks Na/K –> increases intracell Ca –> increase contractility (last line!)
2nd line for AF in HF patients –> increase vagal tone, decrease conduction through SA/AV node
omalizumab
anti IgE antibody
asthma
mepolizumab
il-5 antibody
asthma
reslizumab
il-5 antibody
asthma
benralizumab
il-5 antibody
asthma
dupilumab
il-4 antibody
asthma