Exam 2: Ch. 6-9 Flashcards

1
Q

John F. Burke

Ioannis V. Yannas

A

Two engineers who worked together to pioneer the first use of artificial skin in surgery

Their work helps many burn victims

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2
Q

Epidermis

A

The outermost layer of the skin

Doesn’t have its own direct blood supply

Receives nutrients from blood vessels in the outermost portion of the dermis

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3
Q

Layers of the Epidermis

A

Stratum Corneum - Thick layer of skin, mostly stratified squamous cells, these cells are DEAD and act like roofing material/protection

Stratum Granulosum - A layer containing keratin granules. In this layer, some cells are alive, while many begin to die off.

Stratum Spinosum - A layer containing bundles of pre-keratin and Langerhans’ cells (immune cells)

Stratum Basale - The deepest, most active, growing layer of skin where cells divide via mitosis. The cells begin to migrate outward. Comprised mostly of simple cuboidal cells.

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4
Q

Structures within the Epidermis

A

Gland Pores & Tracts

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5
Q

Cells within the Stratum Basale

A

Melanocytes - pigment-producing cells that darken the skin
Melanin granules - cytoplasmic structure that carries melanocytes outward
Merkel cells - sensory cells that can elicit pain signals

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6
Q

Vellum Hair

A

Fine, translucent hair that is located all across the human body

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7
Q

Dermis

A

The middle layer of the skin houses accessory structures such as glands, muscles, nerves, and vascular tissue.

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8
Q

Layers of the Dermis

A

Papillary Layer - Spongy, flexible layer of the dermis
Reticular Layer - Rigid, fibrous layer of dermal tissue

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9
Q

Structures within the Dermis

A

Hair Follicle - Produces a hair shaft, made of multiple layers of cells

Pacinian Corpuscle - Large, round structures located deep in the dermis, used to sense deep touch

Meissner’s Corpuscle - Small, bulbous structures located in the dermis just below the stratum basale, used to sense light touch

Free Nerve Endings - Structures that run through the dermis and partially into the epidermis, used to sense temperature and touch

Merkel Discs - Nerve endings that connect to the Merkel Cells within the stratum basale

Sebaceous Glands - Release oil (sebum) that is used by hair shafts to give hair a smooth texture

Eccrine Sweat Glands - Release sweat

Arrector Pili Muscles - allow hair to “stand” and for the skin to exhibit goosebumps

Blood Vessels - The dermis is highly vascularized

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10
Q

Hypodermis

A

Also called the subcutaneous layer, the hypodermis is the deepest layer of skin. This layer has the most variation in levels of thickness. This layer is primarily composed of adipose or areolar tissue, both of which function as shock absorbers and as insulators.

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11
Q

Friction Ridges

A

Skin with a higher density which is mostly found in places of high contact such as the fingers, face, armpits, and joints

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12
Q

Hair Follicle Shape

A

Round Shaft - Straight Hair
Oval Shaft - Wavy Hair
Ribbon (Elongated Oval) Shaft - Curly Hair

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13
Q

Layers of the Hair Follicle Wall

A

Connective Tissue Root Sheath - Outermost
Glassy Membrane - Deep to the CTRS
External Epithelial Root Sheath - Deep to the Glassy Membrane
Internal Epithelial Root Sheath - Innermost

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14
Q

Layers of Hair

A

Cuticle - The outermost layer of the hair
Cortex - The middle layer of the hair
Medulla - The inside layer of the hair

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15
Q

Hair Color in relation to Pigment and Mineral levels

A

Black Hair - High Pigmentation - Low to No Minerals

Brown Hair - High Pigmentation - High Minerals

Blonde Hair - Low to No Pigmentation - High Minerals

White - Low to No Pigmentation - Low to No Minerals

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16
Q

Red Hair

A

An abundance of the pigment pheomelanin as well as mineral deposition of specifically iron both contribute to red hair.

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17
Q

Gray Hair

A

Individuals with gray hair have decreased melanin production

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18
Q

Melanin Pigment Types

A

Eumelanin - Brownish/black in color. The primary pigment type produced

Pheomelanin - Pink or red depending on concentration. Commonly found in lips, nipples, glands of the penis and vagina, etc.

Trichochromes - Pigments produced without significant color, often associated with red hair

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19
Q

Hair Growth Phases

A

Anagen (early & mature) - The growth phase, lasts 6-8 years

Catagen - Degenerative phase, lasts 2-3 weeks

Telogen - Resting phase, lasts 1-3 months

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20
Q

Key Anatomical Structures of the Nail

A

Lunule - The active, growing region of the nailbed. Lighter in color and crescent moon shaped.

Body of the Nail - The main structure of the nail

Nail Bed - Highly vascularized, pink-colored structure underneath the nail body

Free edge of the nail - The area humans use when “probing” the environment

Eponychium - Referred to as the cuticle, a thin layer of skin between the nail and the rest of the skin on the proximal end

Hyponychium - A thin layer of skin underneath the nail on the free edge (distal) end

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21
Q

Albinism

A

A condition in which an individual does not produce melanin, thus having a lack of skin and hair pigmentation. This condition also impacts eye development.

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22
Q

Proposed Factors in Skin Color Variation

A

Vitamin D Needs - high levels of melanin are common in countries close to the equator because those countries receive higher UV exposure, thus generating less Vitamin D from within the body. Near the poles, however, individuals receive less UV exposure, which in turn causes lower melanin levels so that Vitamin D synthesis can occur from what little sun exposure there is.

UV Exposure Risks - UV penetrance is HIGHER at the equator and LOWER when closer to the poles

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23
Q

The Rule of Nines

A

A tool clinicians use to estimate skin surface areas in diagnoses. It is commonly used for estimating burn injuries

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24
Q

Levels of Burns

A

1st Degree Burn - Burned skin region is shallow, usually limited to the epidermis

2nd Degree Burn - Burned skin region is deeper and results in blistering, burn penetrates to the dermis but not all the way through

3rd Degree Burn - Burned skin region is through all layers of the skin, deeper tissue is exposed

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25
Sudoriferous Glands
Sweat Glands
26
Ceruminous Glands
Glands of the ear canal that contribute to the production of cerumen (earwax)
27
Mammary Glands
Milk-producing glands located in the breasts
28
Disorders of the Integumentary System
Acne - Inflammation of the sebaceous glands, the follicle becomes blocked Dermatitis - Any inflammation of the skin, typically marked by redness and itchiness Eczema - Itchy, red, "weeping" skin lesions caused by an allergy Psoriasis - Recurring, reddened plaques covered with silvery scale Rosacea - A red, rash-like area, often in the nose or cheeks, marked by a fine network of blood vessels
29
Bernard Siegfried Albinus
Famous for his drawings in "Tables of the Skeleton and Muscles of the Human Body" Both a scientist & an artist
30
Axial Skeleton
The skull, vertebral column, and the thoracic cage
31
Appendicular Skeleton
Bones of the limbs, pectoral & pelvic girdles, hands, & feet
32
Types of Cartilages
Hyaline - Found in the costal cartilages of the ribs, elbow joints, wrist joints, hips, knees, ankles, and the larynx via thyroid and cricoid cartilages Elastic - Found in the external ears, the nose, and the epiglottis Fibrocartilage - Found in the intervertebral discs and the pubic symphysis
33
Types of Bones
Long - One dimension is longer than the others Flat - They develop between 2 or more membranes Irregular - Bones that fit no other category, no specific shape or structure can help identify them as short, long, or flat Short - Roughly the same size in all dimensions, box-like Sesamoid - smooth & round like a sesame seed
34
Long Bone Examples
Fibula Tibia, Ulna, Radius, Phalanges
35
Short Bone Examples
Carpals, Tarsals, Ankle Bones (Talus)
36
Flat Bone Examples
Sternal Bones & Cranial Bones
37
Irregular Bones Example
Vertebrae
38
Sesamoid Bones Example
Patella
39
Structural Design of Long Bones
Epiphysis - Knob-like ends of typical long bones, composed of both compact and spongy bone tissues Diaphysis - The long, shaft-like portion of the long bone, composed of primarily compact bone tissue Epiphyseal Discs/Lines/Cartilages - The "line" between Epiphyses and Diaphyses, composed of cartilage, becomes ossified bone after puberty Red Bone Marrow - Site of production of (red & white) blood cells and platelets, resides in the cavities of spongy tissue. Yellow Bone Marrow - Helps recruit blood cell "building blocks" into the bone
40
Structural Design of Flat Bone Tissue
Two layers of compact bone with spongy bone "sandwiched" between the two compact layers
41
Types of Bone Tissue
Compact - Dense, solid, strong, rigid Spongy - Many "holes" or spaces, called trabeculae, throughout, weaker
42
Functions of the Skeletal System
Framework to encase, hang, & connect parts of the body Blood cell production Mineral storage
43
Types of Bone Cells
Osteogenic Cell - A stem cell that can develop into a variety of specialized cells (many listed below) Osteoblast - The cells that build bone tissue by embedding calcium into the bone tissue, responsible for cell growth Osteocyte - The cells that comprise bones, mature bone cells that maintain the bone matrix Osteoclast - Cells that leech calcium from bone tissues, bone-resorbing cells, the opposite of osteoblasts. These cells help to provide calcium to the rest of the body
44
Growth & Sex Hormone Levels
GH levels are high prenatally and remain high until the onset of puberty when they begin to slowly decline. SH levels spike shortly prenatally, then return to 0 until the onset of puberty, when they then begin to rise slowly. They remain high throughout adulthood.
45
Cartilage Injuries
Torn cartilages often take 5+ months to repair themselves because they have no direct blood supply Over-working bones in childhood/teenage years can cause the epiphyseal plates to ossify early and stunt growth.
46
Cholecalciferol
An important coenzyme that helps to maintain strong bone health and density
47
What happens when Ca2+ (Calcium) levels in the blood fall?
Parathyroid (PTH) levels rise, stimulating osteoclasts to leech calcium from the bones
48
What happens when Ca2+ levels rise?
The thyroid gland undergoes a process called calcitonin, which stimulates calcium salt deposits in the bones
49
Critical Coenzymes in Bone Health
Cholecalciferol (Vitamin D3) - Promotes bone health Calcitriol - impacts deposition into bones, resorption, kidney function, etc. Calcitonin - Promotes mineralization and lowers Ca2+ levels in the blood.
50
Bone Diseases
Osteoporosis - Increased bone weakness, bones become porous and brittle, increased risk of fracture/breaking. Occurs more frequently in elderly women and women who have had many children. Osteogenesis - A defect in collagen deposition that renders bones extremely brittle, resulting in fractures present at birth or occurring with extraordinary frequency during childhood. Can cause tooth deformity and hearing loss Achondroplasia - A disease that causes dwarfism via bones that are non-responsive to GH Hypothyroid Activity - Low thyroid activity causes dwarfism due to decreased & irregular growth rates Pituitary Gigantism - The pituitary gland produces GH in excess, causing bones to grow abnormally large Acromegaly - GH is produced at a constant rate throughout puberty and adulthood instead of tapering off, causing facial distortion and irregular bone growth post-ossification
51
Chelation Therapy
Intravenous administration of chemicals designed to absorb toxic substances that have accumulated in the body. Used frequently for the treatment of exposure to heavy metals such as lead, mercury, cobalt, etc.
52
Steps in Fracture Healing
When a fracture initially occurs, a HEMATOMA (pool/clot of blood) forms Formation of the FIBROCARTILAGINOUS CALLUS (mass of repair tissue containing collagen fibers and cartilage) BONY CALLUS forms (spongy bone from the ossification of the fibrocartilaginous callus) BONE REMODELING occurs (the fracture is healed)
53
Common Types of Fractures
Comminuted - Bone fragments in three or more pieces, common in aged people with brittle bones Compression - The bone is crushed, common in porous bones (osteoporosis) Spiral - Ragged break occurs when excessive twisting forces are applied to a bone, common in sports Epiphyseal - The epiphysis of the bone separates from the diaphysis along the epiphyseal plate, occurs where cartilage cells are dying and calcification is occurring Depressed - Broken bone portion is pressed inward, occurs in the skull Greenstick - Bone breaks incompletely, similar to how a green twig would break, common in children whose bones have more organic matrix and are more flexible
54
Sinuses
Openings in the body that are lined with mucous membranes. They produce moisture & warmth
55
Unique Features of the Pelvic Girdle
Sexually Dimorphic (different in men vs. women) Male openings through the coxal bones are smaller, Female openings are larger for childbirth. Female pelvic girdle structure causes more wear & tear due to the position of the legs being slightly anterior to the vertebral column
56
Foot Arches
Medial Longitudinal - Runs heel to toe along the middle of the foot Lateral Longitudinal - Heel to toe along the lateral/sides of the feet Transverse - Runs from one side of the foot to the other
57
Cleft Palette
One part of a child's maxilla doesn't develop, resulting in abnormal facial structures
58
Sir John Charnley
Surgeon who pioneered the use of artificial joints in the early 1960s
59
Types of Joints
Fibrous Joints - Created via fibrous connective tissues that allow virtually no movement Cartilaginous Joints - Created via cartilages that allow small amounts of movement Synovial Joints - Highly movable joints comprised of bones with a fibrous joint capsule surrounding it that allows a far greater ROM between the two articulating bones
60
Types of Fibrous Joints
Cranial Sutures - "lines" of fibrous connective tissue that hold the different cranial bones in place. Fibrous tissue is very short in length. Syndesmosis - A joint held together by a ligament. Fibrous tissue is longer than it is in sutures Gomphosis - "Peg in socket" type of fibrous joint. Short fibrous tissues hold the "peg" in the "socket."
61
Types of Sutures
Serrate Suture - Zig-Zag ridges that fit together similar to a dovetail joint in woodworking Lap suture - Diagonal ridges that fit together similar to a miter joint in woodworking Plane suture - Straight/Flat ridges that fit together similar to a butt joint in woodworking
62
Where are Syndesmosis Joints found?
The tibiofibular joints are examples of syndesmosis joints
63
What is an example of a Gomphosis Joint?
A tooth in its socket is an example of a gomphosis joint
64
Types of Cartilaginous Joints
Synchondroses - Bones united by hyaline cartilage Symphyses - Bones united by fibrocartilage
65
What is an example of a synchondrosis joint?
The joint between the first rib and the manubrium of the sternum
66
What is an example of a symphysis?
The pubic symphysis or the mandibular symphysis
67
What are the structures that make up a Synovial Joint?
Articular Cartilage - A layer of protective tissue that covers the articulating surfaces Synovial Membrane - A membrane between bones that produces synovial fluid that acts as a lubricant. The membrane is very delicate Fibrous Capsule - A sheet of fibrous tissue that surrounds the synovial membrane and provides support Ligamental Tissue - Connective tissue that holds bones together and limits the amount of movement they can display Bursae - fluid-filled sacs that act as cushions between articulating bones and provide further support in the ROM of a joint.
68
Categories of Synovial Joints
Plane Joint - Limited 2D movement Hinge Joint - Rotational 2D movement Pivot Joint - Specialized 2D movement Condyloid Joint - Limited 3D rotational movement Saddle Joint - Specialized 3D movement Ball & Socket Joint - Wide-ranging 3D movement
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Where are Plane Joints found?
Carpals & Tarsals
70
Where are Hinge Joints found?
Elbows & Knees
71
Where are Pivot Joints found?
Radioulnar Joint
72
Where are Condyloid Joints found?
Between metacarpals & phalanges AND between metatarsals & phalanges
73
Where are Saddle Joints found?
ONLY between the carpals & metacarpals of our thumbs
74
Where are Ball & Socket Joints found?
The femur in the acetabulum of the coxal bone & the humerus in the glenoid cavity of the scapula
75
What is the Temporomandibular Joint?
The joint between the mandibular condyle and the cranium. Side-to-side movement of this joint can cause inflammation and potential joint failure. This kind of movement is commonly the cause of TMJ disorder
76
Arthritis
Rheumatoid Arthritis - Chronic inflammation and joint degeneration that is the result of an autoimmune response Osteoarthritis - Wear failure of joints, the articulating surfaces simply wear out
77
Other Joint Disorders
Gout - A disease in which uric acid crystals accumulate in the joints and irritate the articular cartilage and synovial membrane Synovitis - Inflammation of a joint capsule, often a complication of a sprain Tendinitis - A form of bursitis in which a tendon sheath is inflamed
78
Kenneth Gustke
Developed/designed many artificial joints