Exam 2 - Flashcards
What does it mean when there’s lots of solutes in the outside fluid, but little in the inside?
Hypertonic - A LOT of tonicity (solutes)
If the interstitial fluid is hypertonic, water will leave the cells to balance the tonicity between the intercellular and interstitial compartments which will shrink the cells.
What happens when a cell shrivels up due to hypertonicity?
Cells cannot function when they shrink.
At what point will we have a non-functioning cell?
When the interstitial fluid is hypertonic (too much solute) relative to the intercellular fluid.
What happens to a cell when it is hypotonic?
When an interstitial fluid is hypotonic, and doesn’t have as many solutes as INSIDE the cell, so the water moves from outside the cell INTO the cell to balance the tonicity… so the cell literally explodes.
Is Alzheimers disease related to hypertonicity or hypotonicity?
Hypotonic
How do the different fluid compartments work together?
Layers that border on each other
Changes in the tonicity of one compartment will have effects on the next compartment, etc
Solution C – intracellular fluid
B – Intrastitial fluid
A - Blood
What is Thirst?
Thirst is a feeling or motivational state we experience when fluid is lost from our body and we need to replenish it
Thus, THIRST is the signal that initiates the correctional mechanism (drinking)
What causes us to approach water?
The feeling of thirst initiates the behavior of DRINKING (correctional mechanism)
Where do we lose the most water out of all these if we don’t exercise:
Perspiration
Evaporation
Respiration
Respiration
How much water do we lose in a day?
2.5L or 8 cups.
What are the 2 types of thirst?
- Osmotic – pure water thirst; remedy for this thirst is pure water.
+Happens when there’s a decrease in the intracellular fluid (because it moved to a different compartment)
+Caused by increased tonicity of the interstitial fluid
+Too many solutes for the level of fluid
Water is pulled out of cells to balance the solution
- Hypovolemic – low vol. thirst
+Initiated when there’s a decrease in total fluid volume
>e.g., serious blood loss, vomiting, diarrhea
How does Osmotic thirst happen?
Starts with blood being too hypertonic
When we eat, we are thirsty, especially when eating salty food
Also happens because we are losing water with salts due to excessive perspiration or excessive urination
I am eating dry ass saltine crackers with extra salt. What is the tonicity of my blood?
Hypertonic - the salt increases the tonicity of my blood. The water is drawn out of the interstitial fluid from the intracellular fluid in attempts to balance the fluid between the 2 compartments… The water leave cells to regain isotonic state but leaves SOLUTES, and there is increased concentration of solutes in the interstitial compartment.
What do osmoreceptors detect?
Where is it located?
Osmoreceptors in the brain detect cell dehydration (hypertonicity).
Monitors movement of water
Located in the OVLT near the 3rd ventricle by the blood brain barrier- when blood is hypertonic, it’s instantly aware of that.
What affects osmoreceptor firing rates?
Osmoreceptors signal the decrease in intracellular fluid levels by shrinking - the smaller they are, the more they fire. Larger they are, the less they fire.
When the osmoreceptors begin firing at higher rates, they stimulate cells in the _____________ __________ cells to release anti-diuretic hormone (ADH).
Posterior pituitary cells to release anti-diuretic hormone (ADH).
What is anti-diuretic hormone? What releases this?
It serves as the bandaid - you’ve already lost intracellular water, so that is why the OVLT is firing, so that we can prevent losing more water. So you stop sweating and such.
The Posterior pituitary cells releases this hormone.
What does the osmoreceptors also communicate with?
It also communicate with the Lateral Hypothalamus to promote drinking behavior.
Then the Lateral Hypothalamus in turn communicates with the Zona Inserta, to drink water.
>maybe selected for in evolution when water was not as available
What are the connections and projections from the OVLT?
OVLT connects to Posterior Pituitary Cells to produce the ADH, also projects from OVLT to Medial preoptic nucleus in the Hypothalamus to the Zona Inserta.
What happens when we stimulate Zona Inserta in animals?
They look for water and drink it.