Exam 2 Flashcards
How is a membrane potential established
It arises from the unequal distribution of ions (inside of the cell is more negative, outside is more positive)
What is equilibrium potential
The membrane potential at which the net flow of ions is zero
How is membrane potential maintained
Na+/K+ pump and leaky channels
What is depolarization
Membrane potential increases caused by cations entering or anions exiting
What is hyperpolarization
Membrane potential decreasing caused by cations exiting or anions entering
Reception zone of the neuron
Incoming signals are received in dendrites and converted to a change in membrane potential
Integration zone of the neuron
A change in membrane potential initiates action potentials in the axon hillock
Conduction zone of the neuron
Action potentials are conducted to axon terminals
Signal transmission zone of the neuron
Neurotransmitter release transmits a signal to the target cell
Graded potentials
Caused by ligand gated ion channels (more ligands, more depolarization)
Transient signals that occur at a specific location
Short distance
Vary in magnitude and direction
Stronger stimuli=stronger depolarization
Action potentials
All or none
Spatial summation - graded potentials close together which increases threshold
Temporal summation - increasing membrane potentizl little by little
Threshold
Membrane potential required to initiate an action potential
Absolute refractory period
The time when another action potential cannot be triggered
Relative refractory period
The time when a much stronger stimuli is required to trigger action potential
Relationship of stimulus strength to axon potentials
Stronger stimulus = higher frequency of AP’s
Key events of neurotransmitter release
Synthesized in neuron, released at pre-synapse following depolarization, bind & cause effect at post-synapse
Sensory neurons
Afferent
Unipolar
Trigger zone at interface between dendrites and axon
Carry impulse from PNS to CNS
Interneurons
Connect one neuron to another, multipolar and have many terminals, unmyelinated, many dendrites
Motor neurons
Efferent, multipolar, carry signal from CNS to target organ to elicit a response
How does myelination increase action potential conduction speed
It restricts the action potentials to the nodes of ranvier which forces electronic spread through the internodes
How does large-diameter axons increase action potential conduction speed
They decrease resistance to electrical current flow
Ionotropic vs metabotropic
Ionotropic are receptors that open/close upon a neurotransmitter binding
Metabotropic is when a neurotransmitter binds to a receptor and causes a signal transduction to occur which causes the opening/closing of a different channel elsewhere
Tonic receptors
Decrease response to stimulus as duration increases (ex. sitting down)
Phasic receptors
Firing many action potentials all at once and then stops and quickly adapts to stimulus