exam 2 Flashcards
true or false
If performing antibody testing in infectious mononucleosis and the EBNA IgG is negative, the patient has not had a recent (acute) infection.
true
This hepatitis is known as a severe and rapidly progressive liver disease with no proven effective therapy.
HepD
The viruses polio, hepatitis A, rabies, and Japanese encephalitis are examples of ________ vaccines.
- dna
- live, attenuated
- inactivated
- virus like
inactivated
describe the correct order of vaccine development
- ID and sequence pathogen
- determine target
- conduct preclinical trials
- initial human trials
- obtain regulatory approval
- estabilish manufacturing
Which type of infection has three forms which include: lymphatic, disseminated, and respiratory
- cryptococcus
- sporotrichosis
- north american blastomycosis
- aspergillosis
sporotrichosis
Which disease has the causative agent found mainly in soil contaminated with chicken, bird, or bat excreta.
- histoplasmosis
- aspergillosis
- coccidioidomycosis
- sporotrichosis
histoplasmosis
Which is the important antibody to test in suspected causes of congenital rubella
IgM
True or False
Herpes simplex virus 2 is generally found in and around oral cavities and skin lesions above the waist.
false
herpes 2 is lower
herpes 1 is upper
True or false
In immunohistochemistry, the indirect method is more versatile than the direct method.
true
type I hypersensitivity is what kind of rxn
anaphylactic
what type of hypersensitivity reaction is cell mediated
IV
Which type of cytotoxic injury is the mechanism of injury in antibody mediated glomerulonephritis.
- antibody-dependent, compliment mediated cytotoxic rxn
- antibody-dependent, cell mediated cytotoxicity
- anti receptor antibodies
antibody-dependent, cell mediated cytotoxicity
Type IV reactions are moderated by the link between what cells
T lymphs and phagocytic cells
This type of vaccine is the closest to exposure to natural infection
live attenuated
The FTA-ABS test is a
treponemal method
Unlike some procedure, the PCR assay can be used to detect Lyme disease causing organisms in:
- urine
- CSF
- synovial fluid
- blodd
synovial fluid
One of the most common physical findings in adults with ehrlichiosis is:
fever
West Nile virus causes:
- encephalitis
- polio
- measles
- arthritis
encephalitis
Serologic procedures for the diagnosis of recent infection should include:
- only acute specimen
- only convalescent specimen
- acute and convalescent specimens
- acute, convalescent, and 6 month post infeciton specimen
acute and convalescent
Toxoplasmosis is a ___________ infection.
parasitic
Lyme disease is a _________ type of infection.
bacterial
IgG antibodies to rubella virus increase rapidly for _______ days after the acquisition of the infection.
7-21
A type II hypersensitivity reaction is a:
cytotoxic rxn
An example of a delayed nonhemolytic (type II hypersensitivity) reaction is:
graft vs host disease
Which infectious disease can alter T lymphocyte subsets?
- toxoplasmosis
- rubella
- rubeola
- cmv
- varicella-zoster virus
cmv
Treponema carateum is the causative organism associated with the disease
- yaws
- syphilis
- pinta
- bejel
pinta
Treponema pallidum is the causative organism associated with the disease
- syphilis
- yaws
- pinta
- bejel
syphilis
Which symptomatic neurosyphilis involves inflammation of the pia mater?
meningovascular
What is the enzyme that dissolves clots by converting plasminogen to plasmin?
streptokinase
True or False
EBV causes an increase in CD8+ T cells.
true
What is the major virulence factor for S. pyogenes?
M protein
EBV-infected B lymphocytes express all the following new antigens except:
- VCA
- EA
- NA
- CA
CA
what is erythrogenix toxin associated with
scarlet feverw
what role dose hyaluronidase play in regards to strep infections
spreading factor
explain the major characteristics of Dengue Fever
- 3 phases: febrile, critical and spontaneous recovery
- spread by mosquitos
explain signs and symptoms of CMV
- herpes virus
- congenital is most common w/ long term health problems
Lyme disease effect on innate immune system cells
reduce NK cells and increase suppressor cells
describe ehrlichiosis
- from lone star tick
- non specific symptoms but fatal
explain the tests for VCA IgG and EBNA IgG for mono
- no previous exposure= negative to both
- recent acute infection = pos VCA, neg EBNA
- past (convalescent)= pos to both
- reactivation = pos to both
what type of hypersensitivity rxn is farmers lung
type III, immune complexes
the calssic tests to demonstrate the presence of strep infection are
- ASO and anti-NADase
- ASO and anti-DNase B
- anti-NADse and anti-DNase
- both a and b
ASO and anti-DNase B
up to ___ of infants develop antibody to HHV-6 by 10-11 months of age
- 25%
- 50%
- 75%
- 90%
75%
