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immunology exam qs/objectives > exam 2 > Flashcards

exam 2 Flashcards

1
Q

true or false
If performing antibody testing in infectious mononucleosis and the EBNA IgG is negative, the patient has not had a recent (acute) infection.

A

true

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2
Q

This hepatitis is known as a severe and rapidly progressive liver disease with no proven effective therapy.

A

HepD

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3
Q

The viruses polio, hepatitis A, rabies, and Japanese encephalitis are examples of ________ vaccines.
- dna
- live, attenuated
- inactivated
- virus like

A

inactivated

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4
Q

describe the correct order of vaccine development

A
  • ID and sequence pathogen
  • determine target
  • conduct preclinical trials
  • initial human trials
  • obtain regulatory approval
  • estabilish manufacturing
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5
Q

Which type of infection has three forms which include: lymphatic, disseminated, and respiratory
- cryptococcus
- sporotrichosis
- north american blastomycosis
- aspergillosis

A

sporotrichosis

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6
Q

Which disease has the causative agent found mainly in soil contaminated with chicken, bird, or bat excreta.
- histoplasmosis
- aspergillosis
- coccidioidomycosis
- sporotrichosis

A

histoplasmosis

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7
Q

Which is the important antibody to test in suspected causes of congenital rubella

A

IgM

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8
Q

True or False
Herpes simplex virus 2 is generally found in and around oral cavities and skin lesions above the waist.

A

false
herpes 2 is lower
herpes 1 is upper

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9
Q

True or false
In immunohistochemistry, the indirect method is more versatile than the direct method.

A

true

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10
Q

type I hypersensitivity is what kind of rxn

A

anaphylactic

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11
Q

what type of hypersensitivity reaction is cell mediated

A

IV

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12
Q

Which type of cytotoxic injury is the mechanism of injury in antibody mediated glomerulonephritis.
- antibody-dependent, compliment mediated cytotoxic rxn
- antibody-dependent, cell mediated cytotoxicity
- anti receptor antibodies

A

antibody-dependent, cell mediated cytotoxicity

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13
Q

Type IV reactions are moderated by the link between what cells

A

T lymphs and phagocytic cells

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14
Q

This type of vaccine is the closest to exposure to natural infection

A

live attenuated

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15
Q

The FTA-ABS test is a

A

treponemal method

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16
Q

Unlike some procedure, the PCR assay can be used to detect Lyme disease causing organisms in:
- urine
- CSF
- synovial fluid
- blodd

A

synovial fluid

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17
Q

One of the most common physical findings in adults with ehrlichiosis is:

A

fever

18
Q

West Nile virus causes:
- encephalitis
- polio
- measles
- arthritis

A

encephalitis

19
Q

Serologic procedures for the diagnosis of recent infection should include:
- only acute specimen
- only convalescent specimen
- acute and convalescent specimens
- acute, convalescent, and 6 month post infeciton specimen

A

acute and convalescent

20
Q

Toxoplasmosis is a ___________ infection.

A

parasitic

21
Q

Lyme disease is a _________ type of infection.

A

bacterial

22
Q

IgG antibodies to rubella virus increase rapidly for _______ days after the acquisition of the infection.

A

7-21

23
Q

A type II hypersensitivity reaction is a:

A

cytotoxic rxn

24
Q

An example of a delayed nonhemolytic (type II hypersensitivity) reaction is:

A

graft vs host disease

25
Q

Which infectious disease can alter T lymphocyte subsets?
- toxoplasmosis
- rubella
- rubeola
- cmv
- varicella-zoster virus

A

cmv

26
Q

Treponema carateum is the causative organism associated with the disease
- yaws
- syphilis
- pinta
- bejel

A

pinta

27
Q

Treponema pallidum is the causative organism associated with the disease
- syphilis
- yaws
- pinta
- bejel

A

syphilis

28
Q

Which symptomatic neurosyphilis involves inflammation of the pia mater?

A

meningovascular

29
Q

What is the enzyme that dissolves clots by converting plasminogen to plasmin?

A

streptokinase

30
Q

True or False
EBV causes an increase in CD8+ T cells.

A

true

31
Q

What is the major virulence factor for S. pyogenes?

A

M protein

32
Q

EBV-infected B lymphocytes express all the following new antigens except:
- VCA
- EA
- NA
- CA

A

CA

33
Q

what is erythrogenix toxin associated with

A

scarlet feverw

34
Q

what role dose hyaluronidase play in regards to strep infections

A

spreading factor

35
Q

explain the major characteristics of Dengue Fever

A
  • 3 phases: febrile, critical and spontaneous recovery
  • spread by mosquitos
36
Q

explain signs and symptoms of CMV

A
  • herpes virus
  • congenital is most common w/ long term health problems
37
Q

Lyme disease effect on innate immune system cells

A

reduce NK cells and increase suppressor cells

38
Q

describe ehrlichiosis

A
  • from lone star tick
  • non specific symptoms but fatal
39
Q

explain the tests for VCA IgG and EBNA IgG for mono

A
  • no previous exposure= negative to both
  • recent acute infection = pos VCA, neg EBNA
  • past (convalescent)= pos to both
  • reactivation = pos to both
40
Q

what type of hypersensitivity rxn is farmers lung

A

type III, immune complexes

41
Q

the calssic tests to demonstrate the presence of strep infection are
- ASO and anti-NADase
- ASO and anti-DNase B
- anti-NADse and anti-DNase
- both a and b

A

ASO and anti-DNase B

42
Q

up to ___ of infants develop antibody to HHV-6 by 10-11 months of age
- 25%
- 50%
- 75%
- 90%

A

75%

immunology exam qs/objectives (5 decks)

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