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immunology exam qs/objectives > exam 1 > Flashcards

exam 1 Flashcards

1
Q

the MHC is divided into how many major regions
a. 2
b. 3
c. 4
d. 5

A

c. 4

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2
Q

which is not one of the 5 important factors in the functioning of antigens
a. degradability
b. structural stability
c. complexity
d. relativity
e. molecular weight

A

d. relativity

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3
Q

MCH class I molecules include the regions:
B, C, D
A, B, D
A, B, C
A, C, D

A

ABC

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4
Q

True or False
Papain generates a single bivalent antigen-binding fragment

A

false

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5
Q

This immunoglobulin variant is the dominant type found on the immunoglobulins of all animals in a species.
a. allotype
b. idiotype
c. isotype

A

isotype

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6
Q

What is the correct order for the phases of antibody response?

A

lag, log, plateau, decline

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7
Q

Which of the following are applications of monoclonal antibodies:
- immunoassay development
- classifications of leukemias and lymphomas
- quantification of hormones
- b and c
- all of the above

A

all of the above

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8
Q

place in the correct order of phagocytosis

A

chemotaxis
adherence
engulfment
phagosome formation
fusion
digestion and destruction

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9
Q

opsonization is the coating of organisms by which two molecules
- Fc and C3
- Fc and C4
- C3 and C4
- Fa and C3

A

Fc and C3

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10
Q

describe adhesion

A

Upregulation of integrins promote activity of cell adhesion molecules on the endothelium

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11
Q

describe tethering

A

First contact of leukocyte with endothelium

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12
Q

describe triggering

A

Neutrophil is prepared to receive signals from chemokines

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13
Q

Monocytes and macrophages are the primary source of which polypeptide hormone:
- IL-1
- IL-17
- IL-10
- IL-25

A
  • IL-1
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14
Q

the cardinal signs of inflammation do not include
- pain
- bruising
- swelling
- redness

A

bruising

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15
Q

chronic inflammation almost always leads to
- fibrosis
- pus formation
- resolution
- acute inflammation

A

fibrosis

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16
Q

the progressive stages of sepsis are
- infection, sepsis, severe sepsis
- sepsis, septic shock, death
- sepsis, severe sepsis, septic shock
- infection, severe sepsis, death

A
  • sepsis, severe sepsis, septic shock
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17
Q

what is the sequence of component activiation in the classic pathway

A

1 4 2 3 5 6 7 8 9

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18
Q

Which acute phase protein has greater specificity for proinflammatory markers for sepsis?
- alpha 1 antitrypsin
- c reactive protein
- procalcitonin
- C4

A

c reactive protein

19
Q

as a group, cytokines
- bind to specific membrane receptors on target cells
- act close to the site of synthesis on the same cell or on a nearby cell
- regulate receptor expression in T and B cells
- both a and b
- all of the above

A

all of the above

20
Q

who is the father of immunology

A

pasteur

21
Q

the innate immune system has how many lines of defense

A

1st and 2nd

22
Q

the adaptive immune system has all but
- the ability to exhibit memory of a prior response
- the ability to rearrange genes
- highly targeted precise response
- an immediate protection component

A

an immediate protection component

23
Q

The stem cell is a common ________ multipotential cell
- cd4
- cd20
- cd34
- cd80

A

CD34

24
Q

Which is not a tissue sentinel cell in the innate immune system?
- macros
- pmns
- mast cell
- dendritic cell

A

pmn

25
Q

what is the order of classical pathway stages

A

recognition, amplification, MAC

26
Q

Which cell’s primary function is host defense against bacterial and fungal infections?
- pmn
- t lymph
- baso
- nk cell

A

pmn

27
Q

Which cell is associated the most with allergic reactions?

A

eosinophil

28
Q

All of the microbes that inhabit different locations in our bodies are called

A

microbiome

29
Q

what is humoral mediated immunity

A

antibodies in action

30
Q

what is cell mediated immunity

A

direct cell-cell contact or soluble products secreted by cells

31
Q

The characteristics of:
- rapid recognition of microbes
- use of widely expressed nonvariant receptors to recognize microbes
- receptors to distinguish self from non-self
are seen in which line of defense?

A

second

32
Q

Which immunoglobulin is commonly found in tears and saliva?

A

IgA

33
Q

True or False
Lymphatic fluid, lymphocytes, and antigens enter the lymph node through the efferent duct and exit through the afferent duct.

A

false

34
Q

Which cell would not be considered to be part of the innate immune system?
- monocytes
- dendritic cells
- NK cells
- t lymphs

A

T lymphs

35
Q

what IL do PMNs respond to from the adaptive immune system

A

IL-17

36
Q

The characteristic associated with IgD is:
- Predominant immunoglobulin in secretions
- Increase in infectious diseases, collagen disorders, and hematologic disorders
- Mediates some types of hypersensitivity reactions
- Primarily a cell membrane immunoglobulin

A

Primarily a cell membrane immunoglobulin

37
Q

An appropriate description of IgG is:
- Accounts for 10% of the Ig pool, largely confined to the intravascular space
- Mediates some types of hypersensitivity
- Found in tears, saliva, colostrum, milk, and intestinal secretions
- Diffuses more readily into extravascular spaces, neutralizes toxins, and binds to microorganisms

A

Diffuses more readily into extravascular spaces, neutralizes toxins, and binds to microorganisms

38
Q

Bonding of antigen to antibody exists exclusively as

A

noncovalent bonding

39
Q

The surface marker for CD3 is found on:
- all or most T lymphs
- helper T
- suppressor-cytotoxic T
- T reg

A

all or most T lymphs

40
Q

A characteristic of Chediak-Higashi Syndrome is:
a. Failure to exhibit increased anaerobic metabolism during phagocytosis
b. Marked defect in cellular response to chemotaxis
c. Mild-to-marked defect in bactericidal ability of neutrophils
d. Defective leukocyte locomotion

A

b. Marked defect in cellular response to chemotaxis
a. is CGD
c. MPO deficiency
d. leukocyte adhesion deficiency

41
Q

The characteristic associated with colony stimulating factor is:
- stimulate hematopoietic growth factor
- Encoding gene located in the HLA region between the HLA-DR and HLA-B loci
- Induces phenotype transformation in non-neoplastic cells
- Also known as IL-2

A

Stimulates hematopoietic growth factor

42
Q

Which of the following conditions can be associated with hypercomplementemia?
- Myocardial infarction
- Systemic lupus erythematosus
- Glomerulonephritis
- Subacute bacterial endocarditis

A

myocardial infraction

43
Q

Which is not one of the 4 main sources of Biological Response Mediators?
- b lymphs
- nk cells
- monocytes
- pmns

A

pmns

immunology exam qs/objectives (5 decks)

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