antigens/antibodies

Question 1

compare MHC I and II

Answer 1

• I: presents to CD8 cells, encodes ABC regions
• II: present to CD4, encodes D region

Question 2

if IgG is treated with papain what happens

Answer 2

dissociates into two FAB fragments and the Fc region intact

Question 3

if IgG is treated with pepsin what happens

Answer 3

cleavage below disulfide bond forms single FAB fragment and the Fc region gets dissociated

Question 4

compare Isotype, Allotype and Idiotype Ig variants

Answer 4

• Iso: found on all animals of a species
• Allo: found on some animals of a species
• Idio: found on each individual antibody

Question 5

describe the characteristis of a primary and secondary (anamnestic) antibody response

Answer 5

• primary: IgM is dominant
• secondary: shorter lag phase, faster log phase and faster IgG lvl increase over IgM

Question 6

antigenic substances can be composed of
- large polysaccharides
- proteins
- glycoproteins
- all of the above

Answer 6

all of the above

Question 7

which of the following statements is false about an anamnestic response vs primary
- has shorter lag phase
- has longer log phase
- antibodies decline more gradually
- IgM antibodies predominate

Answer 7

• IgM predominates