cellular activites/clinical disorders of immune Flashcards
1
Q
what are the steps of phagocytosis
A
- chemotaxis: increases with Fc and C3 attachment
- adhesion: tether, trigger, adhesion
- engulfment
-formation of phagosome:granules fuse to form phagolysosome - fusion: phagolysosome fuses with target vacuole
- digestion
2
Q
macrophages are the primary source of which IL
A
IL-1
3
Q
what are the macrophage activating factors
A
IFNy and TNF alpha
4
Q
define sepsis
A
systemic inflammation in response and an infection with aggressive response
5
Q
what is the role of TH-1
A
cell mediated effecter against pathogens, amplified by IFNy, growth influenced by IL-12
6
Q
what is the role of TH-2
A
regulation of antibody production and parasite defence, amplified by IL-4
7
Q
what is the role of TH-17
A
microbial, bacterial and fungal protection, amplified bu IL-21
